Oxidative activation of indole-3-acetic acids to cytotoxic species— a potential new role for plant auxins in cancer therapy11Abbreviations: IAA, indole-3-acetic acid; HRP, horseradish peroxidase; TBA, thiobarbituric acid; MPO, myeloperoxidase; MOI, 3-methylene-2-oxindole; BSO, buthionine sulphoximine; GSH, glutathione; CEA, carcinoembryonic antigen; ADEPT, antibody directed enzyme prodrug therapy; PDEPT, polymer directed enzyme prodrug therapy; GDEPT, gene directed enzyme prodrug therapy; and …
Data up to Jan 2025
Total Citations Per Year
Abstract
References (39)
Plant hormones : physiology, biochemistry and molecular biology
1995 • 1,018 citations
Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.
1999 • 689 citations
Plant hormones. Physiology, biochemistry and molecular biology
1996 • 582 citations
Are cancer cells acidic?
1991 • 576 citations
Expression of a synthetic gene for horseradish peroxidase C in Escherichia coli and folding and activation of the recombinant enzyme with Ca2+ and heme.
1990 • 280 citations
Auxin Biosynthesis and Metabolism
2007 • 265 citations
One- and Two-Electron Oxidation of Reduced Glutathione by Peroxidases
1986 • 170 citations
One- and two-electron oxidation of reduced glutathione by peroxidases.
1986 • 149 citations
Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase.
1994 • 147 citations
The choice of prodrugs for gene directed enzyme prodrug therapy of cancer.
1995 • 131 citations
Antibody-Enzyme Conjugates for Cancer Therapy
1996 • 101 citations
Antibody directed enzyme prodrug therapy (ADEPT)
1994 • 100 citations
Identification of skatolyl hydroperoxide and its role in the peroxidase-catalysed oxidation of indol-3-yl acetic acid
1998 • 78 citations
Enhancement of Lipid Peroxidation by Indole-3-Acetic Acid and Derivatives: Substituent Effects
1995 • 77 citations
Singlet oxygen production from the peroxidase-catalyzed oxidation of indole-3-acetic acid.
1988 • 67 citations
Free-Radical Intermediates and Stable Products in the Oxidation of Indole-3-acetic acid
1994 • 63 citations
Inhibition of Cell Growth by Photooxidation Products of Indole-3-acetic Acid
1964 • 62 citations
Peroxidase-catalyzed effects of indole-3-acetic acid and analogues on lipid membranes, DNA, and mammalian cells in vitro
1999 • 60 citations
Toward targeted “oxidation therapy” of cancer: peroxidase-catalysed cytotoxicity of indole-3-acetic acids
1998 • 60 citations
The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody
1994 • 58 citations
Antibody-Directed Enzyme Prodrug Therapy
1994 • 54 citations
Rates of Reaction of Indoleacetic Acids with Horseradish Peroxidase Compound I and Their Dependence on the Redox Potentials
1996 • 51 citations
Effect of Indole Acetic Acid on Oxygen Metabolism in Cultured Rat Neutrophil
1998 • 47 citations
The death hormone hypothesis
1989 • 46 citations
Inhibitory Oxidation Products of Indole-3-acetic Acid
1965 • 39 citations
Hypoglycemic Action of Indole-3-Acetic Acid by Mouth in Patients with Diabetes Mellitus.
1956 • 39 citations
FREE RADICALS AND EXCITED SPECIES IN THE METABOLISM OF INDOLE‐3‐ACETIC ACID AND ITS ETHYL ESTER BY HORSERADISH PEROXIDASE AND BY NEUTROPHILS
1992 • 36 citations
The conversion of indole-3-acetic acid to 3-methylene-oxindole in the presence of peroxidase
1961 • 33 citations
Peroxidase Activity May Play a Role in the Cytotoxic Effect of Indole Acetic Acid*
1997 • 33 citations
Excitation of indole acetate in myeloperoxidase-H2O2 system: Possible formation of indole acetate cation radical
1980 • 29 citations
The chemotherapy of colon cancer
1995 • 23 citations
Enhancement of peroxidase-induced lipid peroxidation by indole-3-acetic acid: effect of antioxidants
1996 • 21 citations
Amplification of oxidative stress by decarboxylation: a new strategy in anti-tumour drug design
1995 • 15 citations
Peroxidase-H2O2 catalyzed incorporation of auxin derivatives into sRNA
1976 • 14 citations
Enhanced intracellular stability of dextran-horse radish peroxidase conjugate: ann approach to enzyme replacement theraphy
1992 • 12 citations
Peroxidase content in cell subpopulations of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats.
1982 • 11 citations
The binding of the peroxidase oxidation products of indole-3-acetic acid to histone
1972 • 10 citations
Effects of enzyme/substrate ratio and of cofactors on the oxidation products of indole-3-acetic acid catalyzed by peroxidase.
1983 • 7 citations
Deleted Work
1955 • 0 citations