Thienamycin: development of imipenem-cilastatin

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

Properties of the Penicillin‐Binding Proteins of Escherichia coli K12

1977 • 645 citations

Thienamycin, a new .BETA.-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.

1979 • 502 citations

Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-I

1982 • 340 citations

Structure and absolute configuration of thienamycin

1978 • 297 citations

Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia

1982 • 234 citations

MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities

1980 • 198 citations

Peptidoglycan synthetic enzyme activities of highly purified penicillin-binding protein 3 in Escherichia coli: A septum-forming reaction sequence

1981 • 182 citations

N-Acetimidoyl- and N-formimidoylthienamycin derivatives: antipseudomonal .beta.-lactam antibiotics

1979 • 161 citations

ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY

1966 • 149 citations

Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics

1980 • 113 citations

Binding of Thienamycin and Clavulanic Acid to the Penicillin-Binding Proteins of Escherichia coli K-12

1977 • 108 citations

Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall

1980 • 97 citations

Comparative In Vitro Activity of New Beta-Lactam Antibiotics Against Anaerobic Bacteria

1981 • 95 citations

Escherichia coli resistance to β-lactam antibiotics through a decrease in the affinity of a target for lethality

1978 • 85 citations

Pharmacokinetics and tolerance of N-formimidoyl thienamycin (MK0787) in humans

1983 • 85 citations

Comparative activities of 13 beta-lactam antibiotics

1982 • 84 citations

Effect of organic acid transport inhibitors on renal cortical uptake and proximal tubular toxicity of cephaloridine.

1972 • 71 citations

Susceptibility of enterococci and Listeria monocytogenes to N-Formimidoyl thienamycin alone and in combination with an aminoglycoside

1981 • 63 citations

Susceptibility of pneumococci to 14 beta-lactam agents: comparison of strains resistant, intermediate-resistant, and susceptible to penicillin

1981 • 59 citations

The semi-synthetic thienamycin derivative MK0787 and its properties with respect to a range of β-lactamases from clinically relevant bacterial species

1981 • 51 citations

Susceptibility of Gram-Positive Cocci to Various Antibiotics, Including Cefotaxime, Moxalactam, and N -Formimidoyl Thienamycin

1981 • 48 citations

In vitro susceptibility patterns of methicillin-resistant and-susceptible Staphylococcus auerues strains in a population of parenteral drug abusers from 1972 to 1981

1983 • 44 citations

In vitro activity of N-formimidoyl thienamycin in comparison with cefotaxime, moxalactam, and ceftazidime

1981 • 43 citations

In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin

1980 • 42 citations

Occurrence and expression of imipemide (N-formimidoyl thienamycin) resistance in clinical isolates of coagulase-negative staphylococci

1983 • 41 citations

Lack of in vivo and in vitro bactericidal activity of N-formimidoyl thienamycin against enterococci

1982 • 39 citations

N-Formimidoyl thienamycin (MK0787): in-vitro antibacterial activity and susceptibility to beta-lactamases compared with that of cefotaxime, moxalactam and other beta-lactam antibiotics

1981 • 37 citations

Activities of New Beta-Lactam Antibiotics Against Isolates of Pseudomonas aeruginosa from Patients with Cystic Fibrosis

1981 • 36 citations

N-Formimidoyl-thienamycin a novel β-actam: an in-vitro comparison with other β-lactam antibiotics

1981 • 34 citations

Effects of azlocillin in combination with clavulanic acid, sulbactam, and N-formimidoyl thienamycin against beta-lactamase-producing, carbenicillin-resistant Pseudomonas aeruginosa

1982 • 33 citations

Comparative in vitro susceptibilities of anaerobic bacteria to cefmenoxime, cefotetan, and N-formimidoyl thienamycin

1983 • 33 citations

Synthesis of Sch 29482--a novel penem antibiotic

1982 • 31 citations

In vitro susceptibility of methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains to N-formimidoyl thienamycin

1982 • 26 citations

Comparative activities of N-formimidoyl thienamycin, ticarcillin, and tobramycin against experimental Pseudomonas aeruginosa pneumonia

1982 • 26 citations

In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus

1982 • 23 citations

In Vitro Comparison of N -Formimidoyl Thienamycin, Piperacillin, Cefotaxime, and Cefoperazone

1981 • 22 citations

Susceptibility of Multiply Antibiotic-Resistant Pneumococci to the New Beta-Lactam Drugs and Rosaramicin

1981 • 21 citations

Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis

1982 • 21 citations

A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives

1982 • 20 citations

Enhanced susceptibility of Escherichia coli to intracellular killing by human polymorphonuclear leukocytes after in vitro incubation with chloramphenicol

1981 • 19 citations

In-vitro activity of MK0787 (N-formimidoyl thienamycin) against Pseudomonas aeruginosa and other Gram-negative organisms and its stability to their β-lactamases

1981 • 19 citations

Efficacy of different antibiotics in the treatment of experimentally induced intra-abdominal sepsis

1982 • 17 citations

Bactericidal Activity of Antibiotics Against Campylobacter fetus Subspecies intestinalis

1981 • 15 citations

In vitro Activity and <i>β</i>-Lactamase Stability of N-Formimidoyl Thienamycin Compared to that of Second and Third Generation Cephalosporins

1982 • 15 citations

Sch 29482: Activity against susceptible and -lactam resistant variants of Enterobacteriaceae

1982 • 14 citations

Synergism Between N -Formimidoyl Thienamycin and Gentamicin or Tobramycin Against Enterococci

1982 • 14 citations

Properties of MM 13902 and other carbapenem antibiotics in vitro and in vivo.

1983 • 14 citations

Sch 29482: Comparative activity against Enterobacteriaceae multiply-resistant to -lactam antibiotics and mycobacteria

1982 • 12 citations

Synergistic Effect of N -Formimidoyl Thienamycin with Gentamicin and Amikacin Against Streptococcus faecalis

1983 • 11 citations

Pharmacokinetics of N-formimidoyl thienamycin and influence of a renal dipeptidase inhibitor in experimental meningitis

1983 • 11 citations

In vitro comparison of N-formimidoyl thienamycin (MK0787) and Azlocillin with three aminoglycosides and ticarcillin against Pseudomonas aeruginosa

1982 • 10 citations

N-Formimidoyl-Thienamycin: In-vitro-Aktivität bei Bakterien mit Resistenz gegen Beta-Laktam-Antibiotika oder Gentamicin

1982 • 10 citations

Oral absorption and tolerance in man, of a new penem antibiotic, Sch 29482

1982 • 10 citations

In vitro efficacy of cefoperazone compared with cefotaxime, LY127935, and thienamycin.

1980 • 9 citations

Evaluation of the in-vivo activity of Sch 29482

1982 • 9 citations

N-formimidoyl-thienamycin activity against anaerobes: effect of the inoculum, pH and culture media

1981 • 7 citations

Inhibition of Transpeptidase Activity in Escherichia coli by Thienamycin

1979 • 7 citations

The activity of N-formimidoyl thienamycin (MK0787) against Haemophilus influenzae and Streptococcus pneumoniae

1982 • 7 citations

Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae isolates to N-formimidoyl thienamycin

1982 • 6 citations

A comparative in vitro study of thienamycin

1982 • 6 citations

Comparative Activity of N‐Formimidoyl Thienamycin with Third Generation Cephalosporins and Ureido Penicillins against Multiple Resistant Serratia marcescens

1981 • 5 citations

Comparison of ceftazidime and N-formimidoyl thienamycin against gentamicin-susceptible and resistant Pseudomonas aeruginosa

1983 • 5 citations

[N-Formimidoyl-thienamycin in Animal Studies].

1983 • 5 citations

Growth curve patterns of Escherichia coli and Pseudomonas aeruginosa exposed to different cefsulodin concentrations

1982 • 1 citations