Pharmacologic Modulation of Lung Injury

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Perspectives in platelet-activating factor research.

1987 • 1,383 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

The Adult Respiratory Distress Syndrome

1971 • 774 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

Inflammation and the mechanism of action of anti‐inflammatory drugs

1987 • 523 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

Adult Respiratory Distress Syndrome in Patients with Severe Neutropenia

1986 • 381 citations

Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.

1983 • 340 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Fat Embolism Prophylaxis with Corticosteroids

1983 • 332 citations

Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.

1988 • 317 citations

Neutrophil-mediated Pulmonary Vascular Injury: Synergistic Effect of Trace Amounts of Lipopolysaccharide and Neutrophil Stimuli on Vascular Permeability and Neutrophil Sequestration in the Lung

1987 • 228 citations

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

1983 • 183 citations

Calcium stimulation of a novel lipoxygenase

1980 • 179 citations

Proteases and oxidants in experimental pulmonary inflammatory injury.

1984 • 158 citations

Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects.

1985 • 154 citations

Role of Thromboxane and Prostacyclin in Pulmonary Vasomotor Changes after Endotoxin in Dogs

1981 • 151 citations

Is there a case for PAF antagonists in the treatment of ischemie states?

1989 • 139 citations

Increased Concentrations of Leukotrienes in Bronchoalveolar Lavage Fluid of Patients with ARDS or At Risk for ARDS

1988 • 125 citations

PAF-acether specific binding sites: 2. Design of specific antagonists

1986 • 115 citations

Coronary Vasodilator Properties of Purine and Pyrimidine Derivatives

1956 • 104 citations

Prostacyclin Reversal of Lethal Endotoxemia in Dogs

1981 • 88 citations

Superoxide dismutase with heparin prevents increased lung vascular permeability during air emboli in sheep

1983 • 82 citations

Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak

1985 • 79 citations

Alternative complement pathway activation increases mortality in a model of burn injury in mice.

1982 • 64 citations

Phagocytic Cell-Derived Inflammatory Mediators and Lung Disease

1987 • 52 citations

Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis

1988 • 46 citations

Effect of inhibition of 5-lipoxygenase metabolism of arachidonic acid on response to endotoxemia in sheep

1988 • 37 citations

Pulmonary microvascular permeability to fluid and macromolecules

1988 • 32 citations

Pulmonary response of fifth component of complement-sufficient and -deficient mice to hyperoxia.

1984 • 31 citations

Protective effects of O2 radical scavengers and adenosine in PMA-induced lung injury

1988 • 31 citations

Dimethylthiourea decreases acute lung edema in phorbol myristate acetate-treated rabbits

1986 • 29 citations

Prostaglandin E1 and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury

1982 • 21 citations

The Effects of Prostaglandin E₁on the Adult Respiratory Distress Syndrome in Septic Primates^1–3

1986 • 21 citations

Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin

1983 • 20 citations

Aspiration pneumonia: treatment with pulmonary vasodilators.

1983 • 18 citations

Effects of thromboxane synthase inhibition on air emboli lung injury in sheep

1986 • 17 citations

Human platelets attenuate oxidant injury in isolated rabbit lungs

1988 • 16 citations

Dexamethasone blocks increased leukotriene B4 production during endotoxin-induced lung injury

1988 • 16 citations

Cyclooxygenase inhibition during phorbol-induced granulocyte stimulation in awake sheep

1984 • 15 citations

Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs

1986 • 15 citations

Mepacrine but not Methylprednisolone Decreases Acute Edematous Lung Injury after Injection of Phorbol Myristate Acetate in Rabbits^1,2

1983 • 15 citations

THE ROLE OF ANTIOXIDANTS AND DIET IN THE PREVENTION OR TREATMENT OF OXYGEN‐INDUCED LUNG MICROVASCULAR INJURY*

1982 • 15 citations

Effect of papaverine on pulmonary vascular permeability to proteins

1988 • 14 citations

Effect of intravenous catalase on the pulmonary vascular response to endotoxemia in goats

1988 • 9 citations

Prevention by granulocyte depletion of endotoxininduced adult respiratory distress syndrome. An experimental study in pigs

1987 • 7 citations