Primary Isolated Human Brain Microvascular Endothelial Cells Express Diverse HIV/SIV-Associated Chemokine Coreceptors and DC-SIGN and L-SIGN

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells

2000 • 2,384 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

1999 • 988 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

1993 • 805 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro

2002 • 448 citations

Early penetration of the blood-brain-barrier by HIV.

1988 • 444 citations

Cellular reservoirs of HIV-1 in the central nervous system of infected individuals

1996 • 412 citations

Relationship between human immunodeficiency virus—associated dementia and viral load in cerebrospinal fluid and brain

1997 • 397 citations

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

1992 • 381 citations

?-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia

1998 • 331 citations

Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia

1999 • 302 citations

HIV antigen in the brains of patients with the AIDS dementia complex

1987 • 289 citations

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.

1996 • 288 citations

In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.

1994 • 283 citations

CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain

1997 • 264 citations

Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity

2001 • 263 citations

Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication

1998 • 255 citations

Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages

2001 • 244 citations

Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism.

1993 • 224 citations

DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus

2001 • 224 citations

Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains

1997 • 223 citations

Chemokine Receptor Expression and Signaling in Macaque and Human Fetal Neurons and Astrocytes: Implications for the Neuropathogenesis of AIDS

1999 • 202 citations

An Orphan Seven-Transmembrane Domain Receptor Expressed Widely in the Brain Functions as a Coreceptor for Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

1998 • 196 citations

Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method.

1990 • 188 citations

Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.

1997 • 182 citations

CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4⁺T Cells: Role of signal transduction

1998 • 182 citations

DC-SIGN

2000 • 179 citations

Apoptosis Induced by Infection of Primary Brain Cultures with Diverse Human Immunodeficiency Virus Type 1 Isolates: Evidence for a Role of the Envelope

1999 • 167 citations

Differential signalling of the chemokine receptor CXCR4 by stromal cell‐derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

2000 • 159 citations

Human Immunodeficiency Virus and the Brain: Investigation of Virus Load and Neuropathologic Changes in Pre-AIDS Subjects

1993 • 153 citations

Antigenically Distinct Conformations of CXCR4

2001 • 151 citations

Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.

1998 • 148 citations

Neuroinflammatory signaling upregulation in Alzheimer's disease.

2000 • 146 citations

Human astrocytomas and glioblastomas express monocyte chemoattractant protein‐1 (MCP‐1) in vivo and in vitro

1994 • 144 citations

Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein

2001 • 142 citations

The Effects of Human Immunodeficiency Virus in the Central Nervous System

1998 • 134 citations

AIDS Dementia Is Associated with Massive, Activated HIV-1 Infection and Concomitant Expression of Several Cytokines

1996 • 128 citations

Cerebrospinal fluid HIV-1 RNA levels

1998 • 126 citations

HIV-1 RNA levels in cerebrospinal fluid and plasma correlate with AIDS dementia.

1998 • 101 citations

High sensitivity detection of JC-virus DNA in postmortem brain tissue byin situPCR

2000 • 96 citations

Apelin peptides block the entry of human immunodeficiency virus (HIV)

2000 • 95 citations

Adsorptive endocytosis mediates the passage of hiv-1 across the blood-brain barrier: Evidence for a post-internalization coreceptor

1998 • 92 citations

HIV infection of human brain capillary endothelial cell — Implications for AIDS dementia

1994 • 86 citations

Crosstalk Between Components of the Blood Brain Barrier and Cells of the CNS in Microglial Activation in AIDS

2001 • 86 citations

Apelin, the Natural Ligand of the Orphan Seven-Transmembrane Receptor APJ, Inhibits Human Immunodeficiency Virus Type 1 Entry

2000 • 85 citations

SIV infection of macaques - modeling the progression to AIDS dementia

1998 • 77 citations

Cytopathologic and Neurochemical Correlates of Progression to Motor/Cognitive Impairment in SIV-lnfected Rhesus Monkeys

1994 • 76 citations

Regulation and function of central nervous system chemokines

1995 • 75 citations

Sequence Analysis of the V3 Loop in Brain and Spleen of Patients with HIV Encephalitis

1996 • 73 citations

The neuropathogenesis of HIV-1 infection

1999 • 69 citations

Optimal Inhibition of X4 HIV Isolates by the CXC Chemokine Stromal Cell-derived Factor 1α Requires Interaction with Cell Surface Heparan Sulfate Proteoglycans

2001 • 68 citations

Neurological disorders during HIV-1 infection correlate with viral load in cerebrospinal fluid but not with virus phenotype

1998 • 61 citations

HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

1997 • 61 citations

Differences in Cytokine and Chemokine Responses during Neurological Disease Induced by Polytropic Murine Retroviruses Map to Separate Regions of the Viral Envelope Gene

2001 • 57 citations

Virologic Markers of Human Immunodeficiency Virus Type 1 in Cerebrospinal Fluid

1993 • 53 citations

CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2

2000 • 50 citations

Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4

2001 • 49 citations

The two faces of HIV infection of cerebrospinal fluid

2000 • 47 citations

Sequences regulating tropism of human immunodeficiency virus type 1 for brain capillary endothelial cells map to a unique region on the viral genome

1996 • 47 citations

Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms.

1997 • 45 citations

CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1

2001 • 38 citations

Relationship between viral load in blood, cerebrospinal fluid, brain tissue and isolated microglia with neurological disease in macaques infected with different strains of SIV

2000 • 34 citations

The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases

1999 • 33 citations

Anti-Human Immunodeficiency Virus Type 1 Gene Therapy in Human Central Nervous System-Based Cells: An Initial Approach against a Potential Viral Reservoir

2000 • 30 citations

Development of an in vitro blood-brain barrier model to study molecular neuropathogenesis and neurovirologic disorders induced by human immunodeficiency virus type 1 infection.

2000 • 28 citations

Concentrations of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Cerebrospinal Fluid after Antiretroviral Treatment Initiated during Primary HIV-1 Infection

2001 • 26 citations

HIV in the CNS: Pathogenic relationships to systemic HIV disease and other CNS diseases

2001 • 25 citations

Immunological markers in multiple sclerosis

2000 • 22 citations

In Situ PCR techniques

1997 • 19 citations

Modulation of T cell-endothelial adhesion by astrocyte conditioned medium.

1997 • 12 citations

Modulation of T cell-endothelial adhesion by astrocyte conditioned medium

1997 • 11 citations

Blocking HIV co-receptors by chemokines.

1999 • 7 citations