Cytokine fields and the polarization of the immune response

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1993 • 2,828 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection

2000 • 1,107 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Th 1-type immunity is incompatible with successful pregnancy

1997 • 1,008 citations

CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo

1999 • 998 citations

Synthesis of T helper 2-type cytokines at the maternal-fetal interface.

1993 • 911 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

1999 • 692 citations

Other Functions, Other Genes

1999 • 686 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Control of fetal survival in CBA x DBA/2 mice by lymphokine therapy

1990 • 504 citations

Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.

1997 • 455 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

INFLUENCE OF DOSE AND ROUTE OF ANTIGEN INJECTION ON THE IMMUNOLOGICAL INDUCTION OF T CELLS

1974 • 348 citations

Immunological Phenomena in Leprosy and Related Diseases

1971 • 322 citations

Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient–Induced Determination of Pituitary Cell Types

1999 • 319 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

c-maf Promotes T Helper Cell Type 2 (Th2) and Attenuates Th1 Differentiation by Both Interleukin 4–dependent and –independent Mechanisms

1998 • 303 citations

Human mast cells produce IL-8.

1993 • 302 citations

Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

1997 • 291 citations

Differentiation of human NK cells into NK1 and NK2 subsets.

1998 • 270 citations

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

1992 • 256 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor β Gene

1993 • 221 citations

The Developmental and Molecular Biology of Genes that Subdivide the Body of Drosophila

2000 • 216 citations

Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy.

1965 • 214 citations

Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.

1994 • 203 citations

Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

1999 • 196 citations

Chemokines in lymphopoiesis and lymphoid organ development

2001 • 187 citations

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

1998 • 179 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

T Cell Progenitors Emerge Earlier Than B Cell Progenitors in the Murine Fetal Liver

2000 • 164 citations

Cytolytic T cells with Th1-like cytokine profile predominate in retroorbital lymphocytic infiltrates of Graves' ophthalmopathy.

1993 • 160 citations

Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo

1996 • 152 citations

Th1/Th2 balance in infection

1999 • 150 citations

Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells.

1999 • 144 citations

IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes.

1992 • 143 citations

Stress, Immune Regulation, and Immunity: Applications for Asthma

2000 • 141 citations

An Update on Human Th1 and Th2 Cells

1997 • 136 citations

Germinal centers: form and function

1998 • 132 citations

Computational and Biological Analysis of 680 kb of DNA Sequence from the Human 5q31 Cytokine Gene Cluster Region

1997 • 126 citations

Hypomethylation of the interferon‐γ gene correlates with its expression by primary T‐lineage cells

1995 • 113 citations

A Murine Model of NK Cell Mediated Resorption

1990 • 98 citations

Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes.

1999 • 97 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acuteSchistosoma mansoni infection

1998 • 83 citations

Expression of Recombination Activating Genes in Germinal Center B Cells: Involvement of Interleukin 7 (IL-7) and the IL-7 Receptor

1998 • 75 citations

Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.

1991 • 74 citations

Exclusive Th2 Primary Effector Function in Spleens but Mixed Th1/Th2 Function in Lymph Nodes of Murine Neonates

2000 • 73 citations

Type 1 CD8+ T cell responses during infection with the helminth Schistosoma mansoni.

1996 • 66 citations

Macrophages regulate induction of delayed‐type hypersensitivity and experimental allergic encephalomyelitis in SJL mice

1995 • 63 citations

Cytotoxicity and weak CD40 ligand expression of CD8⁺ type 2 cytotoxic T cells restricts their potential B cell helper activity

1997 • 62 citations

The Stability and Reversibility of Th1 and Th2 Populations

1999 • 60 citations

Glucocorticoids Induce a TH2 Response In Vitro

1997 • 56 citations

Chromatin-based regulatory mechanisms governing cytokine gene transcription

1999 • 55 citations

In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets.

1997 • 54 citations

Autoimmune disorders and pregnancy.

1991 • 54 citations

Dendritic Cells from Peyer's Patch and Spleen Induce Different T Helper Cell Responses

1998 • 53 citations

A Stage-Specific Enhancer of Immunoglobulin J Chain Gene Is Induced by Interleukin-2 in a Presecretor B Cell Stage

1998 • 40 citations

Maintenance of IL-12-responsive CD4+ T cells during a Th2 response inLeishmania major-infected mice

2000 • 39 citations

An interleukin 4-induced DNase I hypersensitive site indicates opening of the _γ1 switch region prior to switch recombination

1989 • 37 citations

In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. I. IL-4 mRNA, not IL-2 mRNA, is abundant in the granulomatous livers, mesenteric lymph nodes, and spleens of infected mice.

1991 • 36 citations

The Activated Type 1–Polarized Cd8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles

1999 • 33 citations

CD8+ T cells in atopic disease

1998 • 29 citations

Interleukin-7, a Non-Redundant Potent Cytokine whose Over-Expression Massively Perturbs B-Lymphopoiesis

1998 • 27 citations

4 Segmentation: A View from the Border

1999 • 26 citations