Crystal structure of a clavaminate synthase–Fe(II)–2‐oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

Dioxygen Activation by Enzymes with Mononuclear Non-Heme Iron Active Sites

1996 • 711 citations

Superconducting Single Crystals of Tl2Ba2CaCu2O8 and YBa2Cu4O8: Crystal Structures in the Vicinity of Tc

1998 • 543 citations

Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

1997 • 426 citations

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

1995 • 419 citations

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1999 • 382 citations

Structure of a cephalosporin synthase

1998 • 337 citations

Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

2002 • 335 citations

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

2000 • 259 citations

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

1997 • 192 citations

The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)

2000 • 175 citations

Chemistry and biosynthesis of clavulanic acid and other clavams

1997 • 146 citations

Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate

1998 • 143 citations

Studies on the active site of deacetoxycephalosporin C synthase

1999 • 114 citations

Structure of proline 3‐hydroxylase

2001 • 107 citations

O: A Macromolecule Modeling Environment

1990 • 103 citations

Kinetic study of thymine 7-hydroxylase from Neurospora crassa

1975 • 74 citations

Substrate Binding to the α-Ketoglutarate-Dependent Non-Heme Iron Enzyme Clavaminate Synthase 2: Coupling Mechanism of Oxidative Decarboxylation and Hydroxylation

1998 • 72 citations

Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase

1999 • 53 citations

Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis

2001 • 51 citations

Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site

1995 • 42 citations

A substrate analogue study on clavaminic acid synthase: possible clues to the biosynthetic origin of proclavamic acid

1993 • 41 citations

Incorporation of 18O-labelled water into oxygenated products produced by the enzyme deacetoxy/deacetylcephalosporin C synthase

1993 • 35 citations

Mechanistic Studies on Thiaminase I: Identification of the Product of Thiamin Degradation in the Absence of the Nucleophilic Cosubstrate

2000 • 18 citations

Mechanistic Studies on Prolyl-4-Hydroxylase: Demonstration That the Ferryl Intermediate Does Not Exchange with Water

2000 • 11 citations