X-ray crystallographic studies of streptavidin mutants binding to biotin

Avidin

1975 • 1,425 citations

Structural Origins of High-Affinity Biotin Binding to Streptavidin

1989 • 1,162 citations

Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.

1989 • 579 citations

Molecular Interaction Between the Strep-tag Affinity Peptide and its Cognate Target, Streptavidin

1996 • 330 citations

Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification

1997 • 292 citations

Crystallographic and thermodynamic comparison of natural and synthetic ligands bound to streptavidin

1992 • 226 citations

Molecular Origins of the Slow Streptavidin-Biotin Dissociation Kinetics

1995 • 215 citations

Structural studies of the streptavidin binding loop

1997 • 202 citations

Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120.

1995 • 201 citations

Intersubunit contacts made by tryptophan 120 with biotin are essential for both strong biotin binding and biotin-induced tighter subunit association of streptavidin.

1995 • 135 citations

Binding to Protein Targets of Peptidic Leads Discovered by Phage Display: Crystal Structures of Streptavidin-Bound Linear and Cyclic Peptide Ligands Containing the HPQ Sequence

1995 • 104 citations

Crystal structure and ligand binding studies of a screened peptide complexed with streptavidin

1992 • 97 citations

Thermodynamic and structural consequences of flexible loop deletion by circular permutation in the streptavidin‐biotin system

1998 • 78 citations

Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex 1 1Edited by I. A. Wilson

1998 • 78 citations

Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin

1994 • 63 citations

Functional Analysis of a Dominant Negative Mutant of Gαi2

1995 • 54 citations

In Crystals of Complexes of Streptavidin with Peptide Ligands Containing the HPQ Sequence the pK of the Peptide Histidine Is Less than 3.0

1997 • 32 citations

Crystallographic analysis of the pH‐dependent binding of iminobiotin by streptavidin

1997 • 15 citations

Structure-Based Design Tools: Structural and Thermodynamic Comparison with Biotin of a Small Molecule That Binds to Streptavidin with Micromolar Affinity

1996 • 14 citations

Topochemical Catalysis Achieved by Structure-based Ligand Design

1995 • 11 citations

Topochemistry for preparing ligands that dimerize receptors

1995 • 9 citations

Preparation of a Protein-Dimerizing Ligand by Topochemistry and Structure-Based Design

1996 • 7 citations