The use of quantitative RT-PCR to measure mRNA expression in a rat model of focal ischemia — caspase-3 as a case study

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Real time quantitative PCR.

1996 • 6,155 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Caspases: killer proteases

1997 • 2,440 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

Experimental designs, 2nd ed.

1957 • 1,781 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia

1998 • 706 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Temporal Profile of in situ DNA Fragmentation after Transient Middle Cerebral Artery Occlusion in the Rat

1995 • 477 citations

Background Review and Current Concepts of Reperfusion Injury

1990 • 323 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Advances in quantitative PCR technology: 5′ nuclease assays

1998 • 256 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

Endonuclease activation following focal ischemic injury in the rat brain

1993 • 211 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Microglia and macrophages are major sources of locally produced transforming growth factor-?1 after transient middle cerebral artery occlusion in rats

1998 • 182 citations

Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons

1998 • 164 citations

Expression of Interleukin-1β Converting Enzyme Gene Family andbcl-2Gene Family in the Rat Brain following Permanent Occlusion of the Middle Cerebral Artery

1997 • 162 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

Global ischemia induces apoptosis-associated genes in hippocampus

1996 • 133 citations

The Role of CED-3-Related Cysteine Proteases in Apoptosis of Cerebellar Granule Cells

1997 • 130 citations

Adjusting for baseline: Change or percentage change?

1989 • 120 citations

Adjusting for baseline: Chamge or percentage change

1992 • 99 citations

Early Endonuclease Activation following Reversible Focal Ischemia in the Rat Brain

1995 • 97 citations

Cloning and Expression of a Rat Brain Interleukin-1β-Converting Enzyme (ICE)-Related Protease (IRP) and Its Possible Role in Apoptosis of Cultured Cerebellar Granule Neurons

1997 • 92 citations

Up-Regulation of theNedd2Gene Encoding an ICE/Ced-3-Like Cysteine Protease in the Gerbil Brain after Transient Global Ischemia

1997 • 64 citations

Uses and abuses of analysis of covariance in clinical trials

1985 • 33 citations

Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats

1996 • 29 citations

Ischemia-induced changes in α-tubulin and β-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride

1993 • 24 citations

Expression of β-actin and a-tubulin mRNA in gerbil brain following transient ischemia and reperfusion up to 1 month

1995 • 18 citations

Regional changes in alpha-tubulin and beta-actin mRNA accumulations after transient ischemia in spontaneously hypertensive rat brains.

1994 • 9 citations