Complement in normal and disease processes

Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.

1954 • 545 citations

HEREDITARY ANGIO-NEUROTIC ŒDEMA

1888 • 513 citations

The Immune-Adherence Phenomenon

1953 • 487 citations

ISOLATION OF ß1F-GLOBULIN FROM HUMAN SERUM AND ITS CHARACTERIZATION AS THE FIFTH COMPONENT OF COMPLEMENT

1965 • 416 citations

THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO

1965 • 404 citations

IMMOBILIZATION OF TREPONEMA PALLIDUM IN VITRO BY ANTIBODY PRODUCED IN SYPHILITIC INFECTION

1949 • 386 citations

CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIES

1963 • 377 citations

Immunological Methods

1963 • 354 citations

Complement Fixation on Cell Surfaces by 19 S and 7 S Antibodies

1965 • 336 citations

Bacterial and Mycotic Infections of Man

1965 • 330 citations

The inflammatory process

1973 • 328 citations

Hereditary angioneurotic edema

1962 • 276 citations

Hemolytic Complement in Synovial Fluid*

1964 • 270 citations

THE LOCALIZATION OF IN VIVO BOUND COMPLEMENT IN TISSUE SECTIONS

1962 • 268 citations

[Pathogenesis of serum sickness].

1959 • 252 citations

THE REACTION MECHANISM OF ß1C-GLOBULIN (C'3) IN IMMUNE HEMOLYSIS

1966 • 250 citations

BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS

1965 • 238 citations

ISOLATION AND CHARACTERIZATION OF TWO ß1-GLYCOPROTEINS OF HUMAN SERUM

1960 • 217 citations

An immunofluorescent study of the skin lesions in systemic lupus erythematosus

1966 • 216 citations

Isolation of a Thermolabile Serum Protein which Precipitates -Globulin Aggregates and Participates in Immune Hemolysis.

1961 • 206 citations

EFFECT OF ANTIBODY AND COMPLEMENT ON PERMEABILITY CONTROL IN ASCITES TUMOR CELLS AND ERYTHROCYTES

1959 • 204 citations

ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT

1963 • 195 citations

COMPLEMENT AS A MEDIATOR OF INFLAMMATION

1967 • 195 citations

SOME PROPERTIES OF AN ESTERASE DERIVED FROM PREPARATIONS OF THE FIRST COMPONENT OF COMPLEMENT

1957 • 173 citations

Lesions in Erythrocyte Membranes Caused by Immune Hæmolysis

1964 • 169 citations

IMMUNOREACTIONS INVOLVING PLATELETS

1958 • 165 citations

EXPERIMENTAL GLOMERULONEPHRITIS

1964 • 162 citations

THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS

1959 • 155 citations

COMPONENTS OF GUINEA PIG COMPLEMENT

1963 • 153 citations

Hereditary deficiency of the second component of complement (C'2) in man.

1966 • 152 citations

Serum Levels of Beta1C Globulin, a Complement Component, in the Nephritides, Lipoid Nephrosis, and Other Conditions *

1964 • 144 citations

Antigenic determinants of human beta-1c and beta-1g-globulins.

1966 • 141 citations

THE COMPLEMENT-DEPENDENT BACTERIOLYTIC ACTIVITY OF NORMAL HUMAN SERUM

1962 • 135 citations

THE SIGNIFICANCE OF SERUM COMPLEMENT LEVELS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE AND SUBACUTE GLOMERULONEPHRITIS AND LUPUS ERYTHEMATOSUS DISSEMINATUS

1960 • 132 citations

C'1 ESTERASE EFFECT ON ACTIVITY AND PHYSICOCHEMICAL PROPERTIES OF THE FOURTH COMPONENT OF COMPLEMENT

1965 • 131 citations

STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS

1963 • 130 citations

Hereditary angioneurotic edema: a clinical survey.

1966 • 127 citations

Detection of Hereditary Angioneurotic Edema by Demonstration of a Reduction in the Second Component of Human Complement

1965 • 123 citations

Bacterial and Mycotic Infections of Man

1965 • 123 citations

Biological Activities of Aggregated Gamma Globulin I. Skin Reactive and Complement-Fixing Properties of Heat Denatured Gamma Globulin.

1959 • 122 citations

THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT

1964 • 122 citations

Studies of aggregated gamma-globulin. I. Sedimentation, electrophoretic and anticomplementary properties.

1960 • 119 citations

HEREDITARY ANGIONEUROTIC EDEMA: A CLINICAL SURVEY

1966 • 117 citations

STUDIES ON THE ACTIVATION OF A PROESTERASE ASSOCIATED WITH PARTIALLY PURIFIED FIRST COMPONENT OF HUMAN COMPLEMENT

1958 • 106 citations

Immunological diseases

1966 • 103 citations

Observations on a Pro-esterase Associated with Partially Purified First Component of Human Complement (C'1).

1956 • 103 citations

STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS

1963 • 102 citations

THE CYTOTOXIC ACTION OF IMMUNE GAMMA GLOBULIN AND COMPLEMENT ON KREBS ASCITES TUMOR CELLS

1959 • 102 citations

COMPLEMENT AS A MEDIATOR OF INFLAMMATION

1963 • 97 citations

Concerning the mechanism of complement action. I. Inhibition of complement activity by diisopropyl fluophosphate.

1956 • 88 citations

Brief Note: Essential Hypocomplementemia: Report of a Case

1960 • 86 citations

Concerning the mechanism of complement action. II. The nature of the first component of guinea pig complement.

1956 • 85 citations

Studies on the Second Component of Complement

1961 • 83 citations

IDENTIFICATION OF THE COMPONENTS OF COMPLEMENT PARTICIPATING IN THE ANTIGLOBULIN REACTION.

1963 • 80 citations

Antigenic Determinants of Human β1C- and β1G-Globulins

1966 • 78 citations

A Single Gene Controlling Hemolytic Complement and a Serum Antigen in the Mouse

1964 • 78 citations

COMPONENTS OF GUINEA PIG COMPLEMENT

1963 • 77 citations

Functions of the Complement System

1961 • 74 citations

Serum complement in children with collagen diseases.

1953 • 73 citations

The Immune-Adherence Phenomenon

1956 • 73 citations

Multiple nature of the third component of guinea-pig complement. I. Separation and characterization of three factors a, b, and c, essential for haemolysis.

1965 • 72 citations

Serum complement in connective tissue disorders.

1958 • 70 citations

COMPLEMENT FIXATION IN DISEASED TISSUES

1961 • 68 citations

SEROLOGICAL STUDIES IN RHEUMATIC FEVER. II. SERUM COMPLEMENT IN THE RHEUMATIC STATE 1

1949 • 65 citations

Studies on the terminal stages of immune hemolysis. VI. Osmotic blockers of differing Stokes' radii detect complement-induced transmembrane channels of differing size.

1979 • 65 citations

Kinetic studies on immune hemolysis. VII. Decay of EAC'1, 4, 2, fixation of C'3, and other factors influencing the hemolytic action of complement.

1954 • 61 citations

Serologic tests for inflammation

1956 • 60 citations

Concerning the Mechanism of Complement Action

1956 • 58 citations

Studies on the Second Component of Complement. I. The Reaction between EAC'1,4 and C'2: Evidence on the Single Site Mechanism of Immune Hemolysis and Determination of C'2 on a Molecular Basis.

1961 • 58 citations

The Role of Complement in Immune Phenomena

1965 • 58 citations

ACTION OF THE FIRST COMPONENT OF COMPLEMENT. ACTIVITATION OF C'1 TO C'1A IN THE HEMOLYTIC SYSTEM.

1964 • 56 citations

Concerning the mechanism of complement action. V. The early steps in immune hemolysis.

1960 • 55 citations

The Osmotic Fragility of Erythrocytes in Experimental Malaria *

1966 • 53 citations

Studies on the role of Ca++ and Mg++ in complement fixation and immune hemolysis. III. The respective roles of Ca++ and Mg++ in immune hemolysis.

1953 • 51 citations

Studies of Aggregated γ-Globulin

1960 • 50 citations

Anaphylatoxin Formation by Purified Human C′1 Esterase

1965 • 50 citations

Precipitating Factor for Aggregated γ-Globulins in Normal Human Sera

1961 • 50 citations

Ciba Foundation Symposium. Complement.

1966 • 50 citations

Concerning the Mechanism of Complement Action

1956 • 49 citations

STUDIES ON THE TERMINAL STEPS OF IMMUNE HEMOLYSIS. I. INHIBITION BY TRISODIUM ETHYLENEDIAMINETETRAACETATE (EDTA).

1964 • 48 citations

Two Antibodies of Related Specificity but Different Hemolytic Efficiency Separated by Centrifugation

1956 • 45 citations

Kinetic Studies on Immune Hemolysis

1954 • 45 citations

A study of the mechanism of the anticomplementary activity of gamma-globulin.

1960 • 43 citations

GUINEA PIG BETA-1C-GLOBULIN: ITS RELATIONSHIP TO THE THIRD COMPONENT OF COMPLEMENT AND ITS ALTERATION FOLLOWING INTERACTION WITH IMMUNE COMPLEXES.

1964 • 40 citations

IN VITRO DAMAGE OF RABBIT PLATELETS BY AN UNRELATED ANTIGEN-ANTIBODY REACTION. I. GENERAL CHARACTERISTICS OF THE REACTION.

1965 • 38 citations

Action of the First Component of Complement

1964 • 38 citations

Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates.

1965 • 36 citations

Studies on the bacteriophageneutralizing activity of serums. I. An assay procedure for normal antibody and complement.

1962 • 34 citations

STUDIES ON IMMUNE HUMAN HEMOLYSIS

1961 • 33 citations

Relationship of Circulating Antigen-Antibody Complexes, Antigen Elimination, and Complement Fixation in Serum Sickness.

1958 • 33 citations

Concerning the mechanism of complement action. IV. The properties of activated first component of guinea pig complement.

1959 • 33 citations

COMPLEMENT IN INFECTIOUS DISEASE IN MAN 1

1946 • 32 citations

Studies on the role of Ca++ and Mg++ in complement fixation and immune hemolysis. II. The essential role of calcium in complement fixation.

1953 • 31 citations

Studies on the Role of Ca++ and Mg++ in Complement Fixation and Immune Hemolysis

1953 • 31 citations

Studies on the Second Component of Complement

1961 • 30 citations

SEROLOGICAL STUDIES IN RHEUMATIC FEVER

1949 • 30 citations

Antibody-Complement Complexes

1965 • 29 citations

Studies on Phagocytosis of Bacteria by the Reticulo-Endothelial System in a Strain of Mice Lacking Hemolytic Complement

1964 • 28 citations

Multiple nature of the third component of guinea-pig complement. II. Separation and description of two additional factors beta and d; preparation and characterization of four intermediate products.

1965 • 28 citations

Studies on the bacteriophage-neutralizing activity of serums. II. Comparison of normal and immune phage-neutralizing antibodies.

1962 • 28 citations

Concerning the Mechanism of Complement Action

1960 • 28 citations

Studies on the Terminal Steps of Immune Hemolysis

1964 • 27 citations

A Study of the Mechanism of the Anticomplementary Activity of γ-Globulin

1960 • 27 citations

The Relation between Hemolysin Concentration and Hemolytic Rate as Measured with Chromium51 Labeled Cells

1958 • 26 citations

On the destruction of erythrocytes and other cells by antibody and complement.

1961 • 26 citations

Inhibition of the Third Component of the Complement System by Derivatives of Aromatic Amino Acids

1965 • 25 citations

Erythrophagocytosis: A Study of the Antigen‐Antibody‐Complement Reaction*

1962 • 24 citations

Inhibition of Complement Activity by Di-isopropyl Fluorophosphate

1955 • 24 citations

Catalysis of C′2 fixation by C′1a

1965 • 24 citations

The Heat-Labile Serum Factor Associated with Intracellular Killing of Staphylococcus Aureus

1965 • 23 citations

Complement in Acute Experimental Malaria I. Total Hemolytic Activity

1966 • 23 citations

Complement in Acute Experimental Malaria II. Alterations in the Components of Complement

1966 • 23 citations

Concerning the Mechanism of Complement Action

1959 • 23 citations

IMMUNOLOGIC SUICIDE AND STUDIES ON THE ROLE OF ANTIBODY AND COMPLEMENT IN CANINE KIDNEY HOMOGRAFT REJECTION*

1964 • 22 citations

Studies on the Second Component of Complement. II. The Nature of the Decay of EAC'1,4,2.

1961 • 21 citations

THE COMPLEMENT DEFICIENT GUINEA PIG: A STUDY OF AN INHERITABLE FACTOR IN IMMUNITY*

1932 • 20 citations

STUDIES ON IMMUNE HUMAN HEMOLYSIS. III. ROLE OF 11 S COMPONENT IN INITIATING THE DONATH-LANDSTEINER REACTION.

1963 • 20 citations

Studies on Complement Defective Rabbits. IV. Blood Clearance of Intravenously Injected S. typhi by the Reticuloendothelial System.

1965 • 20 citations

Guinea Pig β1C-Globulin: Its Relationship to the Third Component of Complement and Its Alteration Following Interaction with Immune Complexes

1964 • 19 citations

STUDIES ON IMMUNE HUMAN HEMOLYSIS

1961 • 18 citations

IN VITRO DAMAGE OF RABBIT PLATELETS BY AN UNRELATED ANTIGEN-ANTIBODY REACTION. II. STUDIES OF THE PLASMA REQUIREMENT.

1965 • 18 citations

THE COMPLEMENT CONTENT OF HUMAN SERA WITH ESPECIAL REFERENCE TO MALARIA 1

1948 • 18 citations

Studies on the Bacteriophage Neutralizing Activity of Serums

1962 • 17 citations

Observations on the treatment of rheumatic fever with salicylate, ACTH and cortisone. II. Combined salicylate and corticoid therapy and attempts at rebound suppression

1958 • 17 citations

Serum β₁A (β₁C) globulin levels in systemic lupus erythematosus: Their relationship to clinical and renal histologic findings

1966 • 16 citations

Properties of anaphylatoxin prepared from purified components of human complement

1966 • 16 citations

HUMORAL FACTORS IN CELLULAR RESISTANCE. II. THE ROLE OF COMPLEMENT AND PROPERDIN IN PHAGOCYTOSIS AND CYTOPEPSIS BY NORMAL AND "IMMUNE" MACROPHAGES.

1964 • 16 citations

Anticomplementary Action of Aspirin

1961 • 14 citations

In Vitro Damage of Rabbit Platelets by an Unrelated Antigen-Antibody Reaction

1965 • 13 citations

IMMUNOLOGIC SUICIDE AND STUDIES ON THE ROLE OF ANTIBODY AND COMPLEMENT IN CANINE KIDNEY HOMOGRAFT REJECTION*

1965 • 13 citations

HUMORAL FACTORS IN CELLULAR RESISTANCE. I. THE EFFECTS OF HEATED AND UNHEATED HOMOLOGOUS AND HETEROLOGOUS SERA ON PHAGOCYTOSIS AND CYTOPEPSIS BY NORMAL AND "IMMUNE" MACROPHAGES.

1963 • 10 citations

CHANGES OF SERUM COMPLEMENT AND PROPERDIN LEVELS IN EXPERIMENTAL TYPHOID FEVER. A LONGITUDINAL STUDY OF THE DISEASE INCLUDING THE INCUBATION PERIOD AND THE PHASE OF RECOVERY FOLLOWING TREATMENT WITH CHLORAMPHENICOL.

1964 • 10 citations

Manifestations of Acute Inflammation in the Plasma

1957 • 10 citations

Demonstration of Particulate Adhesion of the Rieckenberg Type with the Spirochete of Syphilis

1956 • 10 citations

Immunologic studies on systemic lupus erythematosus.

1985 • 9 citations

Die Beeinflussung der Leukozytenphagozytose mit Phlorrhizin

1957 • 8 citations

Humoral Factors in Cellular Resistance

1964 • 8 citations

Effect of pH on Human Complement Activity

1966 • 7 citations

Requirement of C′3, C′5, C′6 and C′7 for the formation of a thermostable intermediate complex between sheep erythrocytes and human complement

1966 • 7 citations

Changes of Serum Complement and Properdin Levels in Experimental Typhoid Fever

1964 • 6 citations

A Note on Serum Complement Activity with Particular Reference to Ulcerative Colitis

1967 • 4 citations

Persistent hypocomplementemic nephritis without clinical manifestation

1966 • 1 citations

Effect of aspirin on complement in vitro and in vivo

1965 • 1 citations

Further studies on the chemotactic factor

1966 • 1 citations

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