Down-regulation of IL-12 by topical corticosteroids in chronic atopic dermatitis

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Clinical Validation and Guidelines for the SCORAD Index: Consensus Report of the European Task Force on Atopic Dermatitis

1997 • 1,005 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

1998 • 721 citations

Atopic dermatitis: New insights and opportunities for therapeutic intervention

2000 • 706 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

The Nonamer UUAUUUAUU Is the Key AU-Rich Sequence Motif That Mediates mRNA Degradation

1995 • 524 citations

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha.

1992 • 500 citations

Lesional expression of interferon-γ in atopic eczema

1994 • 404 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

1995 • 316 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Evidence for a disease-promoting effect of Staphylococcus aureus–derived exotoxins in atopic dermatitis

2000 • 304 citations

Prevalence and role of serum IgE antibodies to the StaphylococcuS aureus–derived superantigens SEA and SEB in children with atopic dermatitis

1999 • 273 citations

Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity

1999 • 258 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Expression of Interleukin-12 is Increased in Psoriatic Skin

1998 • 210 citations

Interleukin 12: A key modulator of immune function

1994 • 190 citations

Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis☆☆☆

1999 • 145 citations

The clinical spectrum of atopic dermatitis

1999 • 140 citations

Identification and induction of human keratinocyte-derived IL-12.

1994 • 137 citations

Differential expression of mRNA encoding interleukin‐12 p35 and p40 subunits in situ

1994 • 77 citations

Immunomodulatory Functions and Molecular Regulation of IL-12

1997 • 54 citations

Plasminogen Activator Inhibitor Type 2 Gene Induction by Tumor Necrosis Factor and Phorbol Ester Involves Transcriptional and Post-transcriptional Events

1996 • 37 citations

Effective Stimulation for IL-12 p35 mRNA Accumulation and Bioactive IL-12 Production of Antigen-Presenting Cells Interacted with Th Cells

1999 • 34 citations

Constitutive Expression of Both Subunits of Interleukin-12 in Human Keratinocytes

1996 • 33 citations

Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: Decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors

1999 • 27 citations

Antigen‐presenting cells and keratinocytes express interleukin‐12 in allergic contact dermatitis

2000 • 25 citations

Characterization of proteins binding the 3′ regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells

1998 • 23 citations

Expression of IL-12 in normal and psoriatic skin

1998 • 2 citations