Humoral regulation of physiological sleep: cytokines and GHRH

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

1998 • 452 citations

Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals

1975 • 266 citations

Endogenous sleep-promoting substances and sleep regulation

1989 • 256 citations

Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines.

1996 • 251 citations

The relationship of interleukin-1 and immune functions to sleep in humans.

1986 • 232 citations

Interleukin 1 alters rat sleep: temporal and dose-related effects

1991 • 223 citations

Microbial Products and Cytokines in Sleep and Fever Regulation

1994 • 215 citations

Vagotomy Blocks the Induction of Interleukin-1β (IL-1β) mRNA in the Brain of Rats in Response to Systemic IL-1β

1998 • 192 citations

Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment.

1997 • 185 citations

Growth hormone-releasing factor enhances sleep in rats and rabbits

1988 • 157 citations

Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep

1995 • 139 citations

Diurnal variation of TNFα in the rat brain

1997 • 135 citations

Diurnal variations of interleukin-1β mRNA and β-actin mRNA in rat brain

1997 • 129 citations

Sleep electroencephalogram delta-frequency amplitude, night plasma levels of tumor necrosis factor alpha, and human immunodeficiency virus infection.

1995 • 122 citations

Prolactin and Rapid Eye Movement Sleep Regulation

1995 • 113 citations

Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat

1988 • 113 citations

Diurnal Variations of Tumor Necrosis Factor Alpha mRNA and Alpha-Tubulin mRNA in Rat Brain

1997 • 109 citations

Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats

1994 • 108 citations

Interleukin-1 is involved in responses to sleep deprivation in the rabbit

1994 • 90 citations

Modulation of IL-1β gene expression in the rat CNS during sleep deprivation

1996 • 89 citations

Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation

1992 • 85 citations

Sleep deprivation increases somatostatin and growth hormone‐releasing hormone messenger RNA in the rat hypothalamus

1997 • 82 citations

Sleep-Associated Changes in Interleukin-1β mRNA in the Brain

1998 • 78 citations

Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system

1996 • 72 citations

Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits

1996 • 71 citations

Hypothalamic growth hormone-releasing hormone mRNA varies across the day in rats

1996 • 66 citations

An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits

1996 • 62 citations

Growth-Hormone-Releasing Hormone Mediates the Sleep-Promoting Activity of Interleukin-1 in Rats

1995 • 60 citations

Inhibition of tumor necrosis factor in the brain suppresses rabbit sleep

1995 • 60 citations

Activation of the systemic production of tumor necrosis factor after exposure to acute stress.

1992 • 58 citations

Interleukin-4 inhibits spontaneous sleep in rabbits

1998 • 57 citations

Changes in rat sleep after single and repeated injections of the long-acting somatostatin analog octreotide

1997 • 54 citations

Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats

1998 • 52 citations

Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits

1997 • 47 citations

Effect of interleukin-1 beta on EEG power density during sleep depends on circadian phase

1996 • 46 citations

Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits

1997 • 31 citations

Sleep Regulatory Substances

1997 • 26 citations

An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits

1998 • 3 citations