Density-dependent tumor cell death and reversible cell cycle arrest: Mutually exclusive modes of monocyte-mediated growth control

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Methods for growth of cultured cells in serum-free medium

1980 • 1,013 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

The initiation of cell division in a contact‐inhibited mammalian cell line

1965 • 807 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei.

1977 • 492 citations

Human interleukin 1 is a cytocidal factor for several tumor cell lines.

1985 • 380 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells.

1986 • 207 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Discrimination Between Neoplastic and Non-Neoplastic Cells In Vitro by Activated Macrophages12

1974 • 191 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Cytolytic and cytostatic activity on tumor cells of circulating human monocytes

1979 • 177 citations

Macrophage Nonimmunologic Recognition: Target Cell Factors Related to Contact Inhibition

1973 • 160 citations

Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor

1978 • 134 citations

SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

1988 • 133 citations

Production of an anti-tumour cytotoxin by human monocytes.

1981 • 133 citations

Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle

1984 • 111 citations

Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.

1987 • 106 citations

Synergistic and overlapping activities of tumor necrosis factor-alpha and IL-1.

1988 • 102 citations

Susceptibility of Normal and Transformed Cell Lines to Cytostatic and Cytocidal Effects Exerted by Macrophages 2

1976 • 97 citations

Role of serum components in density-dependent inhibition of growth of cells in culture. Platelet-derived growth factor is the major serum determinant of saturation density

1980 • 89 citations

Effect of serum on the growth of balb 3T3 A31 mouse fibroblasts and an SV40‐transformed derivative

1976 • 88 citations

Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.

1988 • 78 citations

Synergism between human recombinant gamma-interferon and muramyl dipeptide encapsulated in liposomes for activation of antitumor properties in human blood monocytes.

1985 • 65 citations

Modulation of Cell Proliferation by Macrophages: A Possible Function Apart from Cytotoxic Tumour Rejection

1974 • 63 citations

Monocyte purification with counterflow centrifugation monitored by continuous flow cytometry

1981 • 54 citations

Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by high cell density and inhibition of mRNA synthesis.

1986 • 52 citations

Long-Term Cultivation of Functional Human Macrophages in Teflon Dishes With Serum-Free Media

1988 • 44 citations

Interrelated Effects of Tumor Necrosis Factor and Interleukin 1 on Cell Viability

1988 • 43 citations

Soluble Cytostatic Factor(s) Released from Human Monocytes.

1982 • 38 citations

Destruction of tumor cells by monokines released from activated human blood monocytes: evidence for parallel and additive effects of IL-1 and TNF

1988 • 37 citations

Cytostatic and cytolytic effects of human recombinant tumor necrosis factor on human renal cell carcinoma cell lines derived from a single surgical specimen.

1987 • 35 citations

Growth characteristics of primary tissue cultures from heterotransplanted human colorectal carcinomas in serum-free medium.

1981 • 30 citations

Tumor necrosis factor (TNF) alpha: control of TNF-sensitivity and molecular mechanisms of TNF-mediated growth inhibition

1987 • 30 citations

Activated macrophages and antibodies against the plant lectin, GSI-B4, recognize the same tumor-associated structure (TAS).

1987 • 28 citations

Interferons in Host Defense

1988 • 25 citations

Comparison of recombinant tumor necrosis factor and the monocyte-derived cytotoxic factor involved in monocyte-mediated cytotoxicity.

1987 • 23 citations

Comparison of Five Short-Term Assays That Measure Nonspecific Cytotoxicity Mediated to Tumor Cells by Activated Macrophages

1986 • 19 citations

Tumoricidal effector mechanisms of murine Bacillus Calmette-Guérin-activated macrophages: mediation of cytolysis, mitochondrial respiration inhibition, and release of intracellular iron by distinct mechanisms.

1987 • 18 citations

Cytostatic product(s) released by activated macrophages, unrelated to interleukin 1, tumor necrosis factor α, and interferon-αβ

1988 • 16 citations

Characterization of macrophage recognition and killing of SV40-transformed tumor cells that are "resistant" or "susceptible" to contact-mediated killing.

1988 • 16 citations

SHORT COMMUNICATION: Use of Serum-Free, Compositionally Defined Medium for Analysis of Macrophage Differentiation In Vitro

1988 • 14 citations

Inhibition of target cell mitosis as a measure of the cytostatic effects of activated macrophages on tumor target cells.

1977 • 12 citations

Macrophage‐induced cytostasis: Kinetic analysis of bromodeoxyuridine‐pulsed cells

1985 • 12 citations

Monokine mediated release of intracellular iron in tumor target cells in vitro.

1987 • 11 citations

Complex population kinetics in 3T3 and SV40-3T3 cell cultures

1978 • 11 citations

In vitro responses of nude mouse-xenografted human colon carcinomas exposed to doxorubicin derivatives in tissue culture and in the mouse.

1982 • 8 citations

Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: biochemical, functional, and serological characterization of cytotoxins produced by peripheral blood monocytes isolated by counterflow elutriation.

1986 • 7 citations

Density-Dependent Growth Inhibiting Interactions between 3T3 and SV40-3T3 Cells in Mixed Cultures

1979 • 6 citations

Leukolysins and Cancer

1989 • 3 citations