Ly Antigens Associated with T Cell Recognition and Effector Function

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man

1981 • 871 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody.

1982 • 526 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

1984 • 302 citations

Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse

1968 • 289 citations

Fundamental immunology

1984 • 277 citations

The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumors

1983 • 264 citations

A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure.

1981 • 258 citations

A monoclonal antibody blocking human T cell function

1980 • 239 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function¹

1982 • 223 citations

The mouse T cell receptor: Comparison of MHC-restricted receptors on two T cell hybridomas

1983 • 218 citations

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum

1983 • 217 citations

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

1979 • 208 citations

Charge shift electrophoresis: simple method for distinguishing between amphiphilic and hydrophilic proteins in detergent solution.

1977 • 190 citations

The delineation of antigen receptors on human T lymphocytes

1983 • 162 citations

Lymphoid Cell Surface Interaction Structures Detected Using Cytolysis‐Inhibiting Monoclonal Antibodies

1982 • 155 citations

The role of L3T4 in recognition of Ia by a cytotoxic, H-2Dd-specific T cell hybridoma.

1984 • 146 citations

Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity.

1981 • 142 citations

Monoclonal antibody to L3T4 blocks the function of T cells specific for class 2 major histocompatibility complex antigens.

1984 • 140 citations

Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures.

1983 • 133 citations

Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen.

1982 • 123 citations

Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.

1971 • 113 citations

The Mechanism of CTL‐Mediated Killing: Monoclonal Antibody Analysis of the Roles of Killer and Target‐Cell Membrane Proteins

1983 • 77 citations

The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.

1983 • 77 citations

LY-C

1971 • 76 citations

Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.

1981 • 74 citations

Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: analysis by antibody blocking and selective trypsinization.

1982 • 72 citations

Monoclonal antibodies to the murine Ly-2.1 cell surface antigen.

1982 • 70 citations

A clone-specific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone.

1983 • 59 citations

Effects of Lyt antibodies on T-cell functions: augmentation by anti-Lyt-1 as opposed to inhibition by anti-Lyt-2.

1981 • 45 citations

Mouse Lyt-2 antigen: evidence for two heterodimers with a common subunit.

1982 • 41 citations

Comparison of thymic and peripheral T cell Ly‐2/3 antigens

1984 • 33 citations

The mouse antigen complex—I. Mode of association of the subunits with the membrane

1984 • 29 citations

Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products

1983 • 26 citations

Two "Qa" specificities: Qa-m7 and Qa-m8 defined by monoclonal antibodies.

1983 • 23 citations

Monoclonal anti-Lyt-2 antibodies block the activation of cytolytic T lymphocyte precursors.

1983 • 21 citations

Lyt-2 glycoprotein is synthesized as a single molecular species.

1983 • 20 citations

The mouse antigen complex—II. Structural analysis of the subunits

1984 • 16 citations

Ly-15: a new murine lymphocyte alloantigenic locus.

1981 • 10 citations

Ly-15

1981 • 7 citations

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