ACUTE MYELOID LEUKAEMIA IN THE ELDERLY: BIOLOGY AND TREATMENT

On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group.

1989 • 395 citations

PRINCIPAL RESULTS OF THE MEDICAL RESEARCH COUNCIL'S 8th ACUTE MYELOID LEUKAEMIA TRIAL

1986 • 329 citations

Clonal Development, Stem-Cell Differentiation, and Clinical Remissions in Acute Nonlymphocytic Leukemia

1987 • 319 citations

Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia

1989 • 294 citations

Morphological classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia

1980 • 292 citations

Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlymphocytic leukemia in the elderly.

1990 • 264 citations

Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia

1988 • 236 citations

A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes.

1986 • 225 citations

High-Resolution Chromosomes as an Independent Prognostic Indicator in Adult Acute Nonlymphocytic Leukemia

1984 • 224 citations

Causes of initial remission induction failure in acute myelogenous leukemia

1982 • 201 citations

Clinical and laboratory features of de novo acute myeloid leukaemia with trilineage myelodysplasia

1987 • 185 citations

Maintenance chemotherapy prolongs remission duration in adult acute nonlymphocytic leukemia.

1988 • 164 citations

Clinical Significance of Chromosomal Abnormalities in Acute Nonlymphoblastic Leukemia

1984 • 156 citations

A randomized study of the efficacy of consolidation therapy in adult acute nonlymphocytic leukemia

1984 • 154 citations

Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly.

1984 • 149 citations

DIFFERENTIATION OF MYELOID LEUKAEMIC CELLS: NEW POSSIBILITIES FOR THERAPY

1979 • 141 citations

Efficacy of intensive chemotherapy for acute myelogenous leukemia associated with a preleukemic syndrome.

1989 • 120 citations

Toxicity and immunomodulatory effects of interleukin-2 after autologous bone marrow transplantation for hematologic malignancies

1991 • 118 citations

Intensive antileukemic treatment of patients younger than 65 years with myelodysplastic syndromes and secondary acute myelogenous leukemia

1990 • 112 citations

Intensive chemotherapy is the treatment of choice for elderly patients with acute myelogenous leukemia

1981 • 108 citations

Prediction of survival during induction therapy in patients with newly diagnosed acute myeloblastic leukemia.

1989 • 97 citations

Direct relationship between remission duration in acute myeloid leukemia and cell cycle kinetics: a leukemia intergroup study

1990 • 97 citations

Intensive remission consolidation therapy in the treatment of acute nonlymphocytic leukemia.

1987 • 95 citations

Features affecting outcome during remission induction of acute myeloid leukaemia in 619 adult patients

1986 • 93 citations

Intensive chemotherapy is the treatment of choice for elderly patients with acute myelogenous leukemia

1981 • 92 citations

High-dose cytosine arabinoside as the initial treatment of poor-risk patients with acute nonlymphocytic leukemia: a Leukemia Intergroup Study.

1987 • 82 citations

Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside, vincristine, and prednisone (ROAP)

1981 • 80 citations

Mitozantrone and cytosine arabinoside as first-line therapy in elderly patients with acute myeloid leukaemia

1991 • 79 citations

Alternating v repeated postremission treatment in adult acute myelogenous leukemia: a randomized phase III study (AML6) of the EORTC Leukemia Cooperative Group

1989 • 76 citations

Population‐Based Age‐ and Sex‐Specific Incidence Rates in the 4 Main Types of Leukaemia

1982 • 74 citations

Effect of age on second messenger generation in neutrophils

1991 • 74 citations

Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside, vincristine, and prednisone (ROAP)

1981 • 68 citations

Acute leukemia after a primary myelodysplastic syndrome: immunophenotypic, genotypic, and clinical characteristics [see comments]

1991 • 63 citations

Leukaemia and Lymphoma—an atlas of distribution within areas of England and Wales, 1984–1988

1990 • 61 citations

Acute leukemia after a primary myelodysplastic syndrome: immunophenotypic, genotypic, and clinical characteristics [see comments]

1991 • 55 citations

Treatment of adults with acute myelogenous leukemia: prospective evaluation of high-dose cytarabine in consolidation chemotherapy and with bone marrow transplantation.

1987 • 50 citations

Low-dose ara-C therapy for acute myelogenous leukemia in elderly patients.

1989 • 49 citations

A stage classification for prognosis in adult acute myelogenous leukaemia based upon patients' age, bone marrow karyotype and clinical features

1984 • 47 citations

The treatment of acute myeloid leukaemia preceded by the myelodysplastic syndrome

1992 • 42 citations

Causes of initial remission induction failure in acute myelogenous leukemia

1982 • 36 citations

Colony-Stimulating Factors (rhG-CSF, rhGM-CSF, rhIL-3, and BCFG) Recruit Myeloblastic and Lymphoblastic Leukemic Cells and Enhance the Cytotoxic Effects of Cytosine-Arabinoside

1990 • 33 citations

Difference between young and old patients in characteristics of leukemic cells: Older patients have cells growing excessively in vitro, with low antigenicity despite high HLA-DR antigens

1984 • 27 citations

Acute myeloblastic leukaemia in the elderly

1988 • 25 citations

Relation between Age and Blast Cell Differentiation in Acute Myeloid Leukaemia Patients

1990 • 24 citations

The treatment of patients with newly diagnosed poor prognosis acute myelogenous leukaemia: response to treatment and treatment failure

1991 • 22 citations

RESULTS OF CHEMOTHERAPY FOR UNSELECTED PATIENTS WITH ACUTE MYELOBLASTIC LEUKAEMIA: EFFECT OF EXCLUSIONS ON INTERPRETATION OF RESULTS

1986 • 19 citations

High‐dose ARA‐C (HiDAC) plus asparaginase in elderly patients with acute non‐lymphocytic leukemia: A pilot multicentric study by the Italian cooperative group GIMEMA

1989 • 19 citations

Clinical use of haematopoietic growth factors

1989 • 18 citations

Smoldering acute granulocytic leukemia. Observations on its natural history and morphologic characteristics

1983 • 17 citations

Acute Nonlymphocytic Leukemia in the Elderly: Biology and Treatment

1982 • 15 citations

Survival in the Elderly with Acute Leukemia*

1979 • 14 citations

Remission Induction and Postremission Therapy in Acute Myelogenous Leukemia: British MRC Study

1990 • 14 citations

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