VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation

Harmonizing the Metabolic Syndrome

2009 • 12,951 citations

Pharmacological interventions for somatoform disorders in adults

2014 • 11,438 citations

A human gut microbial gene catalogue established by metagenomic sequencing

2010 • 10,392 citations

Adipose Tissue as an Endocrine Organ

2004 • 5,220 citations

Nonalcoholic Fatty Liver Disease

2002 • 5,091 citations

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

2010 • 3,305 citations

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

2003 • 2,629 citations

Nonalcoholic Fatty Liver Disease

2001 • 2,567 citations

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

2009 • 2,301 citations

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

2010 • 1,769 citations

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

2005 • 1,657 citations

Nonalcoholic fatty liver disease

2005 • 1,616 citations

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

2009 • 1,283 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease

2005 • 1,032 citations

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

2006 • 1,019 citations

Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome

2012 • 1,003 citations

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

2003 • 983 citations

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

2003 • 893 citations

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

2010 • 887 citations

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance

2007 • 823 citations

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis

2001 • 820 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Fatty Liver

2007 • 792 citations

Integration of metabolism and inflammation by lipid-activated nuclear receptors

2008 • 752 citations

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

2011 • 736 citations

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

2009 • 543 citations

Secreted bioactive factors fromBifidobacterium infantisenhance epithelial cell barrier function

2008 • 531 citations

Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease

2007 • 518 citations

Liver Fat in the Metabolic Syndrome

2007 • 452 citations

Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study

2006 • 420 citations

Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells

2008 • 403 citations

Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

2004 • 373 citations

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

2007 • 342 citations

High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH

2007 • 274 citations

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet‐induced nonalcoholic steatohepatitis model in mice†

2008 • 251 citations

Effects of Antibiotic Therapy on Outcomes of Patients With Coronary Artery Disease

2005 • 227 citations

Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth

1990 • 211 citations

Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease

2005 • 207 citations

Obesity and Female Gender Increase Breath Ethanol Concentration: Potential Implications for The Pathogenesis of Nonalcoholic Steatohepatitis

2001 • 205 citations

Should Nonalcoholic Fatty Liver Disease Be Included in the Definition of Metabolic Syndrome?

2008 • 198 citations

The Th17/Treg functional imbalance during atherogenesis in ApoE−/− mice

2009 • 185 citations

Antiatherosclerotic effect of farnesoid X receptor

2008 • 179 citations

Enhanced T-Helper-1 Lymphocyte Activation Patterns in Acute Coronary Syndromes

2005 • 174 citations

Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis

2007 • 174 citations

Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline

1991 • 171 citations

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

2012 • 168 citations

Apolipoprotein E Suppresses the Type I Inflammatory Response In Vivo

2005 • 167 citations

Genes or environment to determine alcoholic liver disease and non‐alcoholic fatty liver disease

2006 • 163 citations

The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis

2009 • 146 citations

Absence of Microbiota (Germ-Free Conditions) Accelerates the Atherosclerosis in ApoE-Deficient Mice Fed Standard Low Cholesterol Diet

2010 • 143 citations

Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis

2012 • 141 citations

Profiling adipocytokine secretion from creeping fat in Crohnʼs disease

2006 • 134 citations

Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress

2010 • 132 citations

Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis

2007 • 124 citations

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

2009 • 120 citations

Counter-Regulatory Role of Bile Acid Activated Receptors in Immunity and Inflammation

2010 • 101 citations

Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation

2011 • 91 citations

Functional Metagenomics: A High Throughput Screening Method to Decipher Microbiota-Driven NF-κB Modulation in the Human Gut

2010 • 90 citations

The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease

2006 • 88 citations

FXR an emerging therapeutic target for the treatment of atherosclerosis

2009 • 81 citations

A Murine Model of Obesity With Accelerated Atherosclerosis

2009 • 77 citations

Should Nonalcoholic Fatty Liver Disease Be Renamed?

2005 • 77 citations

Farnesoid X Receptor Agonist for the Treatment of Liver and Metabolic Disorders: Focus on 6-ethyl-CDCA

2011 • 71 citations

Balancing inflammatory, lipid, and xenobiotic signaling pathways by VSL#3, a biotherapeutic agent, in the treatment of inflammatory bowel disease

2009 • 69 citations

Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

2012 • 61 citations

Vitamin D receptor ligands: the impact of crystal structures

2012 • 55 citations

Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE−/− mice through modulation of Th1/Th2 balance

2008 • 49 citations

Counter-Regulatory Role of Bile Acid Activated Receptors in Immunity and Inflammation

2010 • 49 citations

The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice

2010 • 31 citations

Association of the Metabolic Syndrome With Early Coronary Disease in Families With Frequent Myocardial Infarction

2006 • 19 citations

Effects of Antibiotic Therapy on Outcomes of Patients With Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials

2006 • 15 citations

Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis

2001 • 13 citations

Obesity and female gender increase breath ethanol: Potential implications for the pathogenesis of nonalcoholic steatohepatitis

2000 • 4 citations