Factors in the Design of Active-Site-Directed Irreversible Inhibitors

Nature and Development of Lactic Dehydrogenases

1962 • 947 citations

Direct Evidence for the Presence of Histidine in the Active Center of Chymotrypsin^*

1963 • 649 citations

Mechanism and Structure in Organic Chemistry.

1960 • 590 citations

Mechanism and Structure in Organic Chemistry

1973 • 438 citations

The Nature of the Amino Acid Residues Involved in the Inactivation of Ribonuclease by Iodoacetate

1959 • 409 citations

Biosynthesis of Diphosphopyridine Nucleotide

1958 • 403 citations

A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBIN

1959 • 334 citations

Glucosamine Metabolism

1960 • 293 citations

The Photolysis of Diazoacetylchymotrypsin

1962 • 258 citations

BIOSYNTHESIS OF THE PURINES

1957 • 237 citations

Affinity Labeling—a General Method for Labeling the Active Sites of Antibody and Enzyme Molecules^*

1962 • 217 citations

l-GLUTAMIC ACID DEHYDROGENASE: STRUCTURAL REQUIREMENTS FOR SUBSTRATE COMPETITION: EFFECT OF THYROXINE

1957 • 139 citations

IMMUNOLOGICAL DIFFERENCES OF PHOSPHORYLASES

1957 • 134 citations

Sulfhydryl Groups in Relation to Aldolase Structure and Catalytic Activity¹

1957 • 110 citations

SERINE PHOSPHORIC ACID FROM DIISOPROPYLPHOSPHORYL DERIVATIVE OF EEL CHOLINESTERASE

1954 • 108 citations

Role of l-Glutamine as Donor of Carbamyl Nitrogen for the Enzymatic Synthesis of Citrulline in Agaricus bisporus

1962 • 102 citations

The Interaction of 6-Diazo-5-oxo-l-norleucine with Phosphoribosyl Pyrophosphate Amidotransferase

1963 • 101 citations

Biosynthesis of nucleic acid purines. III. Guanosine 5′-phosphate formation from xanthosine 5′-phosphate and l-glutamine

1959 • 100 citations

Lactic Dehydrogenase

1959 • 100 citations

PORPHYRIN BIOSYNTHESIS IN ERYTHROCYTES

1958 • 99 citations

A new method for labelling the active center of chymotrypsin

1962 • 95 citations

POTENTIAL ANTICANCER AGENTS.¹ LXVI. NON-CLASSICAL ANTIMETABOLITES. III.² 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE

1961 • 72 citations

Isolation of acetyl peptides from acetylchymotrypsin

1958 • 67 citations

Potential Anticancer Agents --L. Non-Classical Antimetabolites--II. Some Factors in the Design of Exo-Alkylating Enzyme Inhibitors, partcularly of Lactic Dehydrogenase

1960 • 63 citations

Modification of a Methionine Residue Near the Active Site of Chymotrypsin

1962 • 63 citations

Affinity Labeling of the Active Sites of Antibodies to the 2,4-Dinitrophenyl Hapten^*

1963 • 60 citations

Analogs of Tetrahydrofolic Acid. X.^1,2 Synthetic and Enzymic Studies on the Contribution of the p-Aminobenzoyl-L-glutamate Moiety of Pyrimidyl Analogs to Binding to Some Folic Cofactor Area Enzymes

1964 • 59 citations

The inhibition of serum cholinesterase by alkyl fluorophosphonates

1948 • 59 citations

Azaserine-reactive Sulfhydryl Group of 2-Formamido-N-ribosylacetamide 5'-Phosphate:l-Glutamine Amido-ligase (Adenosine Diphosphate)

1963 • 57 citations

Role of glutamine in the biosynthesis of cytidine nucleotides in Escherichia coli

1961 • 56 citations

Non-classical antimetabolites. VI. 4-(Iodoacetamido)-salicylic acid, an exo-alkylating irreversible inhibitor

1962 • 48 citations

ANALOGUES OF ACETYL CHYMOTRYPSIN

1957 • 45 citations

THE ENZYMATIC SYNTHESIS OF ANTHRANILIC ACID FROM SHIKIMIC ACID-5-PHOSPHATE AND L-GLUTAMINE¹

1959 • 44 citations

Some aspects of the chemistry and toxic action of organic compounds containing phosphorus and fluorine

1958 • 44 citations

Isozymes and Heteroenzymes

1962 • 41 citations

Some aspects of the chemistry and toxic action of organic compounds containing phosphorus and fluorine

1957 • 38 citations

Reactions involving the carbon?nitrogen bond: Heterocyclic compounds

1959 • 36 citations

Amination of uridine nucleotides to cytidine nucleotides by soluble mammalian enzymes: Role of glutamine and guanosine nucleotides

1958 • 31 citations

The Enzymatic Synthesis of Anthranilate from Shikimate 5-Phosphate and L-Glutamine^*

1963 • 26 citations

Analogs of Tetrahydrofolic Acid. VIII.^1,2 Synthesis of N-[1-(2-Amino-4-mercapto-6-methyl-5-pyrimidyl)-3-propyl]-p- aminobenzoyl-L-glutamic Acid, a Mercapto Analog

1963 • 25 citations

Analogs of Tetrahydrofolic Acid. IX.^1,2 Synthesis of N-[1-(2-Amino-4-hydroxy-6-phenyl-5-pyrimidyl)-3-propyl]-p- aminobenzoyl-L-glutamic Acid, a “Nonclassical” Inhibitor of Some Folic Cofactor Area Enzymes

1963 • 25 citations

Non-classical antimetabolites—VIII. The bridge principle of specificity with exo-alkylating irreversible inhibitors

1962 • 21 citations

Non-classical Antimetabolites. VII.^1,2 The Bridge Principle of Specificity with Exo-alkylating Irreversible Inhibitors

1962 • 15 citations

Non-classical antimetabolites. XI

1963 • 12 citations

Non-classical antimetabolites. V. Further factors in the design of exo-alkylating enzyme inhibitors, particularly of lactic dehydrogenase

1962 • 10 citations

Non-classical antimetabolites. IX. The bridge principle of specificity with exo-alkylating irreversible inhibitors. III. Detection of differences in specificity of enzymic nucleophilic sites by the carbophenoxy group

1962 • 7 citations

MECHANISM OF ACTION OF THE LACTIC DEHYDROGENASE OF THE MAMMALIAN ERYTHROCYTE: I. INFLUENCE OF INHIBITORS

1958 • 5 citations

A general method for labeling the active center of an enzyme molecule

1963 • 2 citations