An overview of cellular and molecular mechanisms in crystal-induced inflammation

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

THE MECHANISM OF ACTION OF COLCHICINE

1967 • 1,049 citations

AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGES

1966 • 868 citations

The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout Syndrome"

1962 • 529 citations

IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID

1961 • 479 citations

MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES EXPOSED TO IMMUNE COMPLEXES AND OTHER PARTICLES

1971 • 439 citations

Physico-Chemical Properties of Silica in Relation to its Toxicity

1966 • 324 citations

ACUTE ARTHRITIS IN MAN AND DOG AFTER INTRASYNOVIAL INJECTION OF SODIUM URATE CRYSTALS

1962 • 265 citations

Clinical Science

1962 • 225 citations

Synovitis of recent onset. A clinicopathologic study during the first month of disease

1972 • 199 citations

CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTS

1966 • 175 citations

Colchicine plasma levels

1970 • 166 citations

Molecular Basis of Gouty Inflammation: Interaction of Monosodium Urate Crystals with Lysosomes and Liposomes

1972 • 161 citations

The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies

1967 • 158 citations

Haemolytic Activity of Suspensions of Different Silica Modifications and Inert Dusts

1965 • 124 citations

Inflammatory reaction after intrasynovial injection of microcrystalline adrenocorticosteroid esters

1964 • 115 citations

THE INFLAMMATORY PROCESS IN ACUTE GOUTY ARTHRITIS. I. ACTIVATION OF HAGEMAN FACTOR BY SODIUM URATE CRYSTALS.

1965 • 98 citations

DIFFERENTIAL MEMBRANOLYTIC EFFECTS OF MICROCRYSTALLINE SODIUM URATE AND CALCIUM PYROPHOSPHATE DIHYDRATE

1971 • 95 citations

Suppression of urate crystal‐induced canine joint inflammation by heterologous anti‐polymorphonuclear leukocyte Serum

1968 • 84 citations

Polymorphonuclear leukocyte motility in vitro. IV. colchicine inhibition of chemotactic activity formation after phagocytosis of urate crystals

1970 • 84 citations

Psychology on a Behaviourist Basis

1972 • 80 citations

Sequential changes in human polymorphonuclear leukocytes after urate crystal phagocytosis. An electron microscopic study

1971 • 79 citations

Complement as a mediator of inflammation in acute gouty arthritis. I. Studies on the reaction between human serum complement and sodium urate crystals.

1973 • 68 citations

PHAGOCYTOSIS OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID

1962 • 58 citations

Crystal-Induced Arthritis

1969 • 57 citations

A historical note: leeuwenhoek's description of crystals from a gouty tophus

1970 • 55 citations

Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation.

1966 • 53 citations

Polymorphonuclear leukocyte motility in vitro. V. Release of chemotactic activity following phagocytosis of calcium pyrophosphate crystals, diamond dust, and urate crystals.

1970 • 52 citations

The synovitis of pseudogout: electron microscopic observations

1968 • 48 citations

Synovial inflammatory response to bacterial endotoxin.

1965 • 36 citations

"Studies on the Nature of Gouty Tophi" by Max Freudweiler, 1899

1964 • 35 citations

The inflammatory process in acute gouty arthritis. II. The presence of Hageman factor and plasma thromboplastin antecedent in synovial fluid.

1966 • 35 citations

Articular cartilage in rheumatoid arthritis: ultrastructure and enzymology.

1974 • 32 citations

Anti-inflammatory effect of the trypsin-kallikrein inhibitor in acute arthritis induced by urate crystals in rabbits.

1970 • 29 citations

Urate crystal arthritis in animals lacking hageman factor

1974 • 28 citations

Crystal Deposition Diseases

1965 • 28 citations

Complement as a mediator of inflammation in acute gouty arthritis. II. Biological activities generated from complement by the interaction of serum complement and sodium urate crystals.

1973 • 27 citations

An experimental model of acute inflammation in man

1966 • 25 citations

Inflammatory process in acute gouty arthritis. 3. Vascular permeability-enhancing activity in normal human synovial fluid; induction by Hageman factor activators; and inhibition by Hageman factor antiserum.

1967 • 24 citations

Studies on crystal-induced chemotactic factor. I. Requirement for protein synthesis and neutral protease activity.

1974 • 24 citations

Experimental gouty synovitis caused by bacterial endotoxin adsorbed onto urate crystals

1974 • 23 citations

Effects of Silicate Polymers on Erythrocytes in Presence and Absence of Complement

1962 • 22 citations

Ultrastructural study of leucocytes and urates in gouty arthritis.

1967 • 21 citations

Studies on the mechanism of inflammation induced by calcium pyrophosphate crystals.

1973 • 14 citations

4 Pathogenesis and Treatment of the Acute Attack of Gout

1970 • 13 citations

Experimental investigations into the origin of gouty tophi

1965 • 9 citations