Clozapine Treatment of Schizophrenia

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

1990 • 1,009 citations

Patterns of Cerebral Blood Flow in Schizophrenia

1992 • 905 citations

Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia

1992 • 882 citations

Frontal-subcortical circuits and neuropsychiatric disorders

1994 • 728 citations

Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs

1988 • 692 citations

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

1992 • 546 citations

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

1992 • 445 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

Neuroleptic-Induced Decrease in Plasma Homovanillic Acid and Antipsychotic Activity in Schizophrenic Patients

1984 • 244 citations

Cost effectiveness of clozapine in neuroleptic-resistant schizophrenia

1993 • 211 citations

The frontal lobes and schizophrenia [published erratum appears in J Neuropsychiatry Clin Neurosci 1995 Winter;7(1):121]

1994 • 202 citations

Schizophrenia—A High‐Risk Factor for Suicide: Clues to Risk Reduction

1992 • 190 citations

Striatal Metabolic Rate and Clinical Response to Neuroleptics in Schizophrenia

1992 • 183 citations

Prospects for pharmacotherapy of schizophrenia

1995 • 165 citations

Perspectives on a Time-dependent Model of Neuroleptic Action

1988 • 84 citations

Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography

1989 • 65 citations