Continuous Quantitative Monitoring of Spontaneous Opiate Withdrawal: Locomotor Activity and Sleep Disorders

Tolerance to and physical dependence on morphine in rats

1963 • 446 citations

Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatment

1972 • 439 citations

Role of different brain structures in the expression of the physical morphine withdrawal syndrome.

1992 • 381 citations

Neural substrates of opiate withdrawal

1992 • 361 citations

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

1990 • 317 citations

Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence

1984 • 265 citations

Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions.

1978 • 258 citations

Quantitative aspects of precipitated abstinence in morphine-dependent rats.

1973 • 252 citations

Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal

1995 • 224 citations

Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat

1994 • 134 citations

Persistence of chronic morphine effects upon activity in rats 8 months after ceasing the treatment

1975 • 103 citations

Morphine withdrawal syndrome: Differential participation of structures located within the amygdaloid complex and striatum of the rat

1979 • 94 citations

Locomotor activity in morphine-dependent and post-dependent rats

1981 • 69 citations

Scientific basis of drug dependence

1971 • 61 citations

Physical dependence produced by central morphine infusions: An anatomical mapping study

1994 • 49 citations

EEG correlates of morphine challenge in post-addict rats

1971 • 42 citations

Ethopharmacological analysis of naloxone-precipitated morphine withdrawal syndrome in rats: a newly-developed “etho-score”

1995 • 37 citations

Real-Time Sleep–Wake Scoring in the Rat Using a Single EEG Channel

1994 • 33 citations

Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine

1988 • 24 citations

Validation of spontaneous morphine withdrawal symptoms in rats.

1991 • 22 citations

Long-term effects of morphine on the electroencephalogram and behavior of the rat

1973 • 16 citations

Changes in the electroencephalogram and REM sleep time during morphine abstinence in pellet-implanted rats.

1975 • 14 citations

Differential protracted effects of morphine and ethylketocyclazocine challenges on EEG and behavior in the rat

1986 • 9 citations