What’s new in non-small cell lung cancer for pathologists the importance of accurate subtyping, EGFR mutations and ALK rearrangements

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

2009 • 7,749 citations

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR

2010 • 5,268 citations

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

2007 • 5,137 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

2009 • 3,957 citations

EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

2005 • 3,807 citations

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

2008 • 3,092 citations

Somatic mutations affect key pathways in lung adenocarcinoma

2008 • 2,653 citations

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers

2005 • 2,285 citations

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

2009 • 2,274 citations

Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

2004 • 1,894 citations

Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK

2009 • 1,805 citations

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

2007 • 1,571 citations

Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non–Small-Cell Lung Cancer: AVAiL

2009 • 1,495 citations

Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

2005 • 1,467 citations

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

2002 • 1,308 citations

Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study

2009 • 1,113 citations

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

2007 • 1,061 citations

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

2010 • 1,007 citations

EML4-ALKFusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer

2008 • 939 citations

Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors

2006 • 824 citations

First-Line Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer Harboring Somatic EGFR Mutations

2008 • 802 citations

EGFR Mutations in Non–Small-Cell Lung Cancer: Analysis of a Large Series of Cases and Development of a Rapid and Sensitive Method for Diagnostic Screening With Potential Implications on Pharmacologic Treatment

2005 • 792 citations

Bronchioloalveolar Pathologic Subtype and Smoking History Predict Sensitivity to Gefitinib in Advanced Non–Small-Cell Lung Cancer

2004 • 749 citations

KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer

2009 • 712 citations

The EML4‐ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild‐type EGFR and KRAS

2009 • 700 citations

The Differential Efficacy of Pemetrexed According to NSCLC Histology: A Review of Two Phase III Studies

2009 • 686 citations

Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

2005 • 669 citations

Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population

2009 • 665 citations

Epidermal Growth Factor Receptor Mutations and Gene Amplification in Non–Small-Cell Lung Cancer: Molecular Analysis of the IDEAL/INTACT Gefitinib Trials

2005 • 609 citations

A mouse model for EML4-ALK -positive lung cancer

2008 • 498 citations

The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers

2005 • 492 citations

EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers

2008 • 465 citations

A Novel, Highly Sensitive Antibody Allows for the Routine Detection ofALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

2010 • 423 citations

Anaplastic lymphoma kinase: signalling in development and disease

2009 • 410 citations

Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors

2008 • 401 citations

Distinct Epidermal Growth Factor Receptor and KRAS Mutation Patterns in Non–Small Cell Lung Cancer Patients with Different Tobacco Exposure and Clinicopathologic Features

2006 • 398 citations

Lung Adenocarcinoma: Modification of the 2004 WHO Mixed Subtype to Include the Major Histologic Subtype Suggests Correlations Between Papillary and Micropapillary Adenocarcinoma Subtypes, EGFR Mutations and Gene Expression Analysis

2008 • 375 citations

TTF-1 Expression in Pulmonary Adenocarcinomas

2002 • 372 citations

Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase

2006 • 364 citations

Update onEpidermal Growth Factor ReceptorMutations in Non–Small Cell Lung Cancer

2006 • 359 citations

Activating Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Are Associated with Improved Survival in Gefitinib-Treated Chemorefractory Lung Adenocarcinomas

2005 • 338 citations

Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4–ALK Fusion Gene

2009 • 324 citations

Expression Profile–Defined Classification of Lung Adenocarcinoma Shows Close Relationship With Underlying Major Genetic Changes and Clinicopathologic Behaviors

2006 • 319 citations

Value of p63 and Cytokeratin 5/6 as Immunohistochemical Markers for the Differential Diagnosis of Poorly Differentiated and Undifferentiated Carcinomas

2001 • 314 citations

ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer

2009 • 314 citations

EML4-ALK Rearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues

2009 • 313 citations

Molecular Characteristics of Bronchioloalveolar Carcinoma and Adenocarcinoma, Bronchioloalveolar Carcinoma Subtype, Predict Response to Erlotinib

2008 • 298 citations

Consensus for EGFR Mutation Testing in Non-small Cell Lung Cancer: Results from a European Workshop

2010 • 283 citations

Thyroid transcription factor‐1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B

2000 • 269 citations

A dideazatetrahydrofolate analog lacking a chiral center at C-6: N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5yl)ethyl[benzoyl]-L-glutamic acid is an inhibitor of thymidylate synthase

1992 • 254 citations

EGFR Mutation Is Specific for Terminal Respiratory Unit Type Adenocarcinoma

2005 • 243 citations

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

2008 • 241 citations

Early-Stage Lung Adenocarcinomas With a Micropapillary Pattern, a Distinct Pathologic Marker for a Significantly Poor Prognosis

2003 • 235 citations

Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non–Small-Cell Lung Cancer

2009 • 234 citations

Lung cancer heterogeneity: A blinded and randomized study of 100 consecutive cases

1985 • 225 citations

Subtyping of Undifferentiated Non-small Cell Carcinomas in Bronchial Biopsy Specimens

2010 • 222 citations

Mucinous Differentiation Correlates with Absence of EGFR Mutation and Presence of KRAS Mutation in Lung Adenocarcinomas with Bronchioloalveolar Features

2007 • 215 citations

Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Material, Using a Panel of Mucin Staining, TTF-1, Cytokeratin 5/6, and P63, and EGFR Mutation Analysis

2010 • 209 citations

Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC

2008 • 207 citations

The Prognostic and Predictive Role of Histology in Advanced Non-small Cell Lung Cancer: A Literature Review

2008 • 204 citations

The Diagnostic Value of TTF-1, CK 5/6, and p63 Immunostaining in Classification of Lung Carcinomas

2007 • 185 citations

Epidermal Growth Factor Receptor Mutations and Their Correlation with Gefitinib Therapy in Patients with Non-small Cell Lung Cancer: A Meta-Analysis Based on Updated Individual Patient Data from Six Medical Centers in Mainland China

2007 • 179 citations

Thyroid transcription factor 1 in pulmonary adenocarcinoma

2004 • 179 citations

Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non–small cell lung carcinomas

2009 • 177 citations

Cellular and Pharmacogenetics Foundation of Synergistic Interaction of Pemetrexed and Gemcitabine in Human Non–Small-Cell Lung Cancer Cells

2005 • 176 citations

Immunoreactivity for Thyroid Transcription Factor-1 in Stage I Non–Small Cell Carcinomas of the Lung

2001 • 176 citations

Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34βE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung

2001 • 175 citations

Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinoma of the lung 3 cm or less in diameter

2000 • 161 citations

p63 Expression in Lung Carcinoma

2004 • 160 citations

EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

2010 • 158 citations

Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study

2003 • 157 citations

EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- and prospective observations in non-small-cell lung cancer

2006 • 152 citations

Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

2005 • 146 citations

Discordance of Molecular Biomarkers Associated with Epidermal Growth Factor Receptor Pathway between Primary Tumors and Lymph Node Metastasis in Non-small Cell Lung Cancer

2009 • 143 citations

Preoperative histological classification of primary lung cancer: accuracy of diagnosis and use of the non-small cell category

2000 • 141 citations

Mutations and Response to Epidermal Growth Factor Receptor Inhibitors

2009 • 133 citations

Endobronchial ultrasound-guided transbronchial needle aspiration for identifying EGFR mutations

2009 • 133 citations

Female Sex and Bronchioloalveolar Pathologic Subtype Predict EGFR Mutations in Non-small Cell Lung Cancer

2005 • 127 citations

Pulmonary adenocarcinomas: classification and reporting

2009 • 124 citations

Bronchioloalveolar Carcinoma and Lung Adenocarcinoma: The Clinical Importance and Research Relevance of the 2004 World Health Organization Pathologic Criteria

2006 • 124 citations

Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non–small cell lung carcinomas

2006 • 123 citations

Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer

2006 • 122 citations

EGFRMutation Is a Better Predictor of Response to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Carcinoma Than FISH, CISH, and Immunohistochemistry

2010 • 121 citations

Novel Epidermal Growth Factor Receptor Mutation-Specific Antibodies for Non-small Cell Lung Cancer: Immunohistochemistry as a Possible Screening Method for Epidermal Growth Factor Receptor Mutations

2010 • 119 citations

Lung Cancer Histologic Type in the Surveillance, Epidemiology, and End Results Registry Versus Independent Review

2004 • 112 citations

P2-328: Is pemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of a phase III trial of pemetrexed vs docetaxel in previously treated patients with advanced non-small cell lung cancer (NSCLC)

2007 • 112 citations

Immunohistochemical Detection of EGFR Mutation Using Mutation-Specific Antibodies in Lung Cancer

2010 • 111 citations

A Brief Retrospective Report on the Feasibility of Epidermal Growth Factor Receptor and KRAS Mutation Analysis in Transesophageal Ultrasound- and Endobronchial Ultrasound-Guided Fine Needle Cytological Aspirates

2010 • 110 citations

Histopathologic classification of lung cancer: Relevance of cytokeratin and TTF-1 immunophenotyping

2004 • 107 citations

TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material

2006 • 104 citations

Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers

2007 • 100 citations

Correlation between morphology and EGFR mutations in lung adenocarcinomas

2008 • 97 citations

TTF-1, Cytokeratin 7, 34βE12, and CD56/NCAM Immunostaining in the Subclassification of Large Cell Carcinomas of the Lung

2004 • 96 citations

Epidermal Growth Factor Receptor Mutation in Lung Cancer are Linked to Bronchioloalveolar Differentiation

2006 • 95 citations

Micropapillary Lung Adenocarcinoma

2009 • 92 citations

The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification

2009 • 84 citations

Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study

2006 • 83 citations

Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung

2005 • 83 citations

Epidermal Growth Factor ReceptorMutation Testing in the Care of Lung Cancer Patients

2006 • 82 citations

EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance

2008 • 80 citations

Gaps in Optimal Care for Lung Cancer

2008 • 78 citations

Dominant Papillary Subtype Is a Significant Predictor of the Response to Gefitinib in Adenocarcinoma of the Lung

2004 • 69 citations

Prognostic Value of Histology in Resected Lung Cancer With Emphasis on the Relevance of the Adenocarcinoma Subtyping

2006 • 69 citations

EGFR and K-ras Mutations Along the Spectrum of Pulmonary Epithelial Tumors of the Lung and Elaboration of a Combined Clinicopathologic and Molecular Scoring System to Predict Clinical Responsiveness to EGFR Inhibitors

2009 • 68 citations

Biological Markers for Non–Small Cell Lung Cancer Patient Selection for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy

2006 • 67 citations

A Correlation between EGFR Gene Mutation Status and Bronchioloalveolar Carcinoma Features in Japanese Patients with Adenocarcinoma

2006 • 67 citations

EGFR Assays in Lung Cancer

2008 • 55 citations

If it's not CK5/6 positive, TTF‐1 negative it's not a squamous cell carcinoma of lung

2008 • 52 citations

Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumors

2004 • 46 citations

Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule

2007 • 44 citations

Prognostic analysis of pulmonary adenocarcinoma subclassification with special consideration of papillary and bronchioloalveolar types

2004 • 41 citations

P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples

2009 • 31 citations

PRS-03: Phase III study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

2007 • 28 citations

Diagnostic reproducibility of squamous cell carcinoma (SC) in the era of histology-directed non-small cell lung cancer (NSCLC) chemotherapy: A large prospective study

2009 • 26 citations

Use of erlotinib or gefitinib as initial therapy in advanced NSCLC.

2010 • 21 citations

P1-166: Influence of tumour patterns in mixed-type adenocarcinoma on post-operative survival

2007 • 8 citations