Molecular insights into enzymes of membrane bilayer assembly

IDENTIFYING NONPOLAR TRANSBILAYER HELICES IN AMINO ACID SEQUENCES OF MEMBRANE PROTEINS

1986 • 1,495 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

PLATELET ACTIVATING FACTOR: A BIOLOGICALLY ACTIVE PHOSPHOGLYCERIDE

1986 • 781 citations

[63] Properties of detergents

1979 • 681 citations

Solubilization of phospholipids by detergents structural and kinetic aspects

1983 • 658 citations

Enzymes of Glycerolipid Synthesis in Eukaryotes

1980 • 626 citations

Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis

1985 • 390 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

PHOSPHOLIPID BIOSYNTHESIS IN YEAST

1989 • 326 citations

Determinants of membrane protein topology.

1987 • 301 citations

Assembly of Phospholipids into Cellular Membranes: Biosynthesis, Transmembrane Movement and Intracellular Translocation

1988 • 267 citations

Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter

1985 • 238 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes.

1987 • 214 citations

MOLECULAR GENETICS OF MEMBRANE PHOSPHOLIPID SYNTHESIS

1986 • 206 citations

Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae

1986 • 204 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

TOPOGRAPHY OF MEMBRANE PROTEINS

1989 • 155 citations

Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase.

1983 • 152 citations

Primary structure and disruption of the phosphatidylinositol synthase gene of Saccharomyces cerevisiae.

1987 • 151 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.

1986 • 148 citations

DYNAMICS OF MEMBRANE LIPID METABOLISM AND TURNOVER

1987 • 147 citations

Purification and Properties of Phosphatidylserine Decarboxylase from Escherichia coli

1974 • 145 citations

Phosphatidylinositol biosynthesis in Saccharomyces cerevisiae: purification and properties of microsome-associated phosphatidylinositol synthase

1983 • 142 citations

Mapping of the alpha-bungarotoxin binding site within the alpha subunit of the acetylcholine receptor.

1986 • 139 citations

Detergent effects on enzyme activity and solubilization of lipid bilayer membranes

1983 • 137 citations

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.

1983 • 135 citations

Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.

1986 • 134 citations

A membrane-bound diacylglycerol kinase that selectively phosphorylates arachidonoyl-diacylglycerol. Distinction from cytosolic diacylglycerol kinase and comparison with the membrane-bound enzyme from Escherichia coli.

1988 • 134 citations

Purification of phosphatidylethanolamine N-methyltransferase from rat liver.

1987 • 130 citations

Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase.

1984 • 128 citations

Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor

1989 • 127 citations

Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase.

1981 • 119 citations

The DNA sequences encoding plsB and dgk loci of Escherichia coli.

1983 • 106 citations

The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats.

1987 • 104 citations

Characterization of the methyltransferases in the yeast phosphatidylethanolamine methylation pathway by selective gene disruption

1989 • 104 citations

Purification and Characterization of Phosphatidate Phosphatase from Saccharomyces cerevisiae

1989 • 104 citations

The metabolism and function of complex lipids

1962 • 99 citations

Phosphatidylinositol synthase from Saccharomyces cerevisiae. Reconstitution, characterization, and regulation of activity.

1986 • 96 citations

Reconstitution of a phospholipid flippase from rat liver microsomes

1987 • 96 citations

Structural characterization of Escherichia coli phosphatidylserine decarboxylase.

1988 • 91 citations

Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. Increased phosphorylation of endogenous diacylglycerol and decreased phosphorylation of didecanoylglycerol in response to platelet-derived growth factor.

1988 • 89 citations

Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae.

1987 • 86 citations

Mutants of Saccharomyces cerevisiae defective in sn-1,2-diacylglycerol cholinephosphotransferase. Isolation, characterization, and cloning of the CPT1 gene.

1987 • 85 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis.

1985 • 84 citations

Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli.

1985 • 82 citations

Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli.

1985 • 80 citations

The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene.

1990 • 80 citations

The sn-1,2-diacylglycerol ethanolaminephosphotransferase activity of Saccharomyces cerevisiae. Isolation of mutants and cloning of the EPT1 gene.

1988 • 78 citations

Functions of diacylglycerol in glycerolipid metabolism, signal transduction and cellular transformation.

1988 • 73 citations

Primary Structure and Product Characterization of the Saccharomyces cerevisiae CHO1 Gene That Encodes Phosphatidylserine Synthase1

1987 • 72 citations

Intracellular Lipid Transport in Eukaryotes

1987 • 70 citations

Nucleotide sequence and characterization of the yeast PSS gene encoding phosphatidylserine synthase

1987 • 70 citations

Kinetic mechanism of phosphatidylethanolamine N-methyltransferase.

1988 • 69 citations

The de novo biosynthesis of Platelet-Activating Factor in rat brain

1989 • 68 citations

Structure and expression of the gene locus encoding the phosphatidylglycerophosphate synthase of Escherichia coli.

1986 • 66 citations

sn-1,2-Diacylglycerol kinase of Escherichia coli. Structural and kinetic analysis of the lipid cofactor dependence.

1986 • 63 citations

Specificity of rat hepatic phosphatidylethanolamine N-methyltransferase for molecular species of diacyl phosphatidylethanolamine.

1988 • 60 citations

Regulation of yeast phosphatidylserine synthase and phosphatidylinositol synthase activities by phospholipids in Triton X-100/phospholipid mixed micelles.

1990 • 60 citations

Kinetic analysis of yeast phosphatidate phosphatase toward Triton X-100/phosphatidate mixed micelles.

1990 • 59 citations

Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain.

1990 • 57 citations

Partial purification and properties of diglyceride kinase from Escherichia coli

1976 • 57 citations

Phosphatidylglycerol biosynthesis in Bacillus licheniformis. Resolution of membrane-bound enzymes by affinity chromatography on cytidinediphospho-sn-1,2-diacylglycerol sepharose

1976 • 55 citations

Purification and characterization of phosphatidylinositol kinase from Saccharomyces cerevisiae.

1988 • 54 citations

sn-1,2-diacylglycerol kinase of Escherichia coli. Diacylglycerol analogues define specificity and mechanism.

1990 • 54 citations

Topography of glycerolepid synthetic enzymes Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles

1981 • 46 citations

Topography of phosphatidylcholine, phosphatidylethanolamine and triacylglycerol biosynthetic enzymes in rat liver microsomes

1980 • 46 citations

Assembly of the endoplasmic reticulum phospholipid bilayer. Transporters for phosphatidylcholine and metabolites.

1987 • 44 citations

Reactivation of D-.beta.-hydroxybutyrate dehydrogenase with short-chain lecithins: stoichiometry and kinetic mechanism

1982 • 42 citations

Mutants of Saccharomyces cerevisiae defective in sn-glycerol-3-phosphate acyltransferase. Simultaneous loss of dihydroxyacetone phosphate acyltransferase indicates a common gene.

1986 • 39 citations

Reconstitution of Saccharomyces cerevisiae phosphatidylserine synthase into phospholipid vesicles. Modulation of activity by phospholipids.

1986 • 35 citations

Lipid Ddpendence of Diacylglyderol Kinase from Escherichia coli

1983 • 33 citations

Lipid‐dependent membrane enzymes

1988 • 32 citations

Phospholipid Dependence of Homogeneous, Reconstituted sn-Glycerol-3-phosphate Acyltransferase of Escherichia coli

1989 • 32 citations

Purification and characterization of a membrane-associated phosphatidylserine synthase from Bacillus licheniformis

1985 • 31 citations

Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene

1988 • 27 citations

Purealin, a novel activator of skeletal muscle actomyosin ATPase and myosin EDTA‐ATPase that enhanced the superprecipitation of actomyosin

1987 • 27 citations

Identification of mitochondrial and microsomal phosphatidylserine synthase in Saccharomyces cerevisiae as the gene product of the CHO1 structural gene

1988 • 24 citations

Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase.

1983 • 21 citations

Diglyceride kinase fromEscherichia colican phosphorylate monoglycerides

1982 • 4 citations