ANTIFOLATE RESISTANCE AND THE GENETIC CONTROL OF DIHYDROFOLATE REDUCTASE ACTIVITY

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.

1968 • 129 citations

Genetic Modification of the Structure and Amount of Dihydrofolate Reductase in Amethopterin-resistant Diplococcus pneumoniae

1964 • 39 citations

INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. I. GENOTYPE DERIVATION AND RECOMBINATIONAL ANALYSES

1969 • 36 citations

CYTOGENETICS OF MOUSE LEUKEMIA L1210. I. ASSOCIATION OF A SPECIFIC CHROMOSOME WITH DIHYDROFOLATE REDUCTASE ACTIVITY IN AMETHOPTERIN-TREATED SUBLINES.

1965 • 31 citations

Dihydrofolate Reductase in Genotypically Distinguishable Amethopterin-resistant Diplococcus pneumoniae

1964 • 28 citations

Selection of Chromosomal Variant in Amethopterin-Resistant Sublines of Leukemia L1210 With Increased Levels of Dihydrofolate Reductase<xref ref-type="fn" rid="FN2">2</xref>

1963 • 25 citations

Association of Increased Dihydrofolate Reductase Levels and Chromosome Alteration in Amethopterin-Resistant Sublines of Leukemia L1210<xref ref-type="fn" rid="FN2">2</xref>

1963 • 24 citations

INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. II. INDIVIDUAL AND DUAL EFFECTS ON THE PROPERTIES AND RATE OF SYNTHESIS OF THE ENZYME

1969 • 23 citations

Chromosomal Mapping by Means of Mutational Induction in Synchronous Populations of Streptococcus faecalis

1966 • 22 citations

INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. III. FURTHER EVIDENCE ON THE EXTENT OF GENIC INVOLVEMENT

1970 • 20 citations

GENETIC STUDIES ON AMETHOPTERIN RESISTANCE IN DIPLOCOCCUS PNEUMONIAE

1960 • 18 citations

THE DISTRIBUTION OF MUTATIONAL SITES AFFECTING RESISTANCE TO AMETHOPTERIN IN DIPLOCOCCUS PNEUMONIAE

1964 • 18 citations

Sequential Biochemical Alteration to Antifolate Resistance in L121O Leukaemia

1967 • 17 citations

Induction of Resistance to A-Methopterin in Diplococcus pneumoniae by Deoxyribonucleic Acid

1957 • 16 citations

Strain variation within Streptococcus faecium var. durans.

1966 • 15 citations

Folate reductase and specific dihydrofolate reductase of the amethopterin-sensitive Streptococcus faecium var durans

1969 • 15 citations

FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS

1964 • 11 citations

Induction of the dihydrofolate reductase of Streptococcus faecium var. durans by folic and by some of its derivatives

1970 • 9 citations

Nucleic acid homology as a measure of genetic compatibility among streptococci and a strain of Diplococcus pneumoniae

1970 • 7 citations

Fate of amethopterin-resistant mutants in L1210 mouse leukemia populations.

1966 • 4 citations

Essays in Microbiology. In Honor of Morris Scherago.

1969 • 2 citations