Single or multiple daily doses of aminoglycosides: a meta- analysis

Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

1987 • 486 citations

The Association of Aminoglycoside Plasma Levels with Mortality in Patients with Gram-Negative Bacteremia

1984 • 385 citations

Experience in Monitoring Gentamicin Therapy during Treatment of Serious Gram-Negative Sepsis

1974 • 359 citations

Once versus thrice daily gentamicin in patients with serious infections

1993 • 351 citations

Effective care of the newborn infant

1992 • 332 citations

Once-daily aminoglycoside therapy

1991 • 332 citations

Once-Daily vs. Continuous Aminoglycoside Dosing: Efficacy and Toxicity in Animal and Clinical Studies of Gentamicin, Netilmicin, and Tobramycin

1983 • 288 citations

In Vivo Postantibiotic Effect in a Thigh Infection in Neutropenic Mice

1988 • 273 citations

Efficacy and Toxicity of Single Daily Doses of Amikacin and Ceftriaxone versus Multiple Daily Doses of Amikacin and Ceftazidime for Infection in Patients with Cancer and Granulocytopenia

1993 • 251 citations

Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.

1986 • 240 citations

Once-daily dosing decreases renal accumulation of gentamicin and netilmicin

1989 • 207 citations

Single, Large, Daily Dosing Versus Intermittent Dosing of Tobramycin for Treating Experimental Pseudomonas Pneumonia

1988 • 204 citations

Adaptive Resistance to Aminoglycoside Antibiotics from First-Exposure Down-Regulation

1990 • 187 citations

Gram-negative rod bacteremia

1965 • 184 citations

The Influence of Dosage Regimen on Experimental Gentamicin Nephrotoxicity: Dissociation of Peak Serum Levels from Renal Failure

1979 • 184 citations

First-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical use

1991 • 156 citations

Once-daily dosing regimen for aminoglycoside plus β-Lactam combination therapy of serious bacterial infections: Comparative trial with netilmicin plus ceftriaxone

1990 • 151 citations

A Critical Reevaluation of the "Therapeutic Range" of Aminoglycosides

1992 • 143 citations

Simultaneous antibiotic levels in “breakthrough” gram-negative rod bacteremia

1976 • 135 citations

A prospective randomized study comparing once- versos twice-daily amikadn dosing in critically ill adult and paediatric patients

1991 • 128 citations

Controversies in meta-analysis: the case of the trials of serum cholesterol reduction

1993 • 120 citations

Meta-analytic stimulus for changes in clinical trials

1993 • 119 citations

Does administration of an aminoglycoside in a single daily dose affect its efficacy and toxicity?

1990 • 111 citations

Netilmicin in the Treatment of Gram-Negative Bacteremia: Single Daily versus Multiple Daily Dosage

1989 • 102 citations

Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs

1978 • 101 citations

The Influence of Tobramycin Dosage Regimens on Nephrotoxicity, Ototoxicity, and Antibacterial Efficacy in a Rat Model of Subcutaneous Abscess

1988 • 88 citations

Single-Dose Daily Gentamicin Therapy in Urinary Tract Infection

1974 • 86 citations

A multicentric study of netilmicin once daily versus thrice daily in patients with appendicitis and other intra-abdominal infections

1989 • 81 citations

Prospective randomized study of once-daily versus thrice-daily netilmicin regimens in patients with intraabdominal infections

1990 • 77 citations

Ototoxicity of tobramycin, gentamicin, amikacin and sisomicin in the guinea pig

1978 • 71 citations

Impact of the dosage schedule on the efficacy of ceftazidime, gentamicin and ciprofloxacin inKlebsiella pneumoniae pneumonia and septicemia in leukopenic rats

1989 • 71 citations

Choice of drug and dosage regimen: Two important risk factors for aminoglycoside nephrotoxicity

1986 • 70 citations

Once-daily versus thrice-daily dosing of netilmicin in combination with β-lactam antibiotics as empirical therapy for febrile neutropenic patients

1993 • 70 citations

Pharmacodynamic parameters and toxicity of netilmicin (6 milligrams/kilogram/day) given once daily or in three divided doses to cancer patients with urinary tract infection

1991 • 68 citations

Comparative kinetics and efficacy of amikacin administered once or twice daily in the treatment of systemic Gram-negative infections

1991 • 64 citations

Comparison of 5 milligrams of netilmicin per kilogram of body weight once daily versus 2 milligrams per kilogram thrice daily for treatment of gram-negative pyelonephritis in children

1992 • 63 citations

Once- versus twice-daily amikacin regimen: efficacy and safety in systemic Gram-negative infections

1993 • 60 citations

Aminoglycoside accumulation kinetics in rat renal parenchyma

1983 • 55 citations

Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model

1985 • 47 citations

Single daily ceftriaxone and tobramycin in the empirical management of febrile neutropenic patients: a randomised trial.

1993 • 41 citations

In-vivo assessment of in-vitro killing patterns of Pseudomonas aeruginosa

1985 • 38 citations

Efficacy and Safety of Once Daily versus Intermittent Dosing of Tobramycin in Rabbits with Acute Pyelonephritis

1988 • 36 citations

Once-daily versus thrice-daily administration of netilmicin in combination therapy ofPseudomonas aeruginosa infection in a man-adapted neutropenic animal model

1989 • 31 citations

Empiric Therapy for Infections in Patients With Granulocytopenia

1984 • 29 citations

The logic and role of meta-analysis in clinical research

1993 • 29 citations

Comparison of once-daily and thrice-daily netilmicin regimens in serious systemic infections: a multicenter study in six Asian countries.

1989 • 27 citations

Dissociation of maximum concentration of kanamycin in plasma and perilymph from ototoxic effect

1984 • 23 citations

Single daily dose therapy with aminoglycosides

1991 • 23 citations

Influence of Dosage Regimen on Experimental Tobramycin Nephrotoxicity

1983 • 22 citations

Comparison of the efficacy and safety of amikacin once or twice-a-day in the treatment of severe gram-negative infections in the elderly.

1993 • 22 citations

Relation of Dosing Regimen to Aminoglycoside Ototoxicity: Evaluation of Auditory Damage in the Guinea Pig

1990 • 20 citations

Amikacin once daily plus metronidazole versus amikacin twice daily plus metronidazole in colorectal surgery.

1992 • 20 citations

Comparative Trial of Single‐Dose Versus Twice‐Daily Sisomicin in Bacteriuric Patients

1977 • 19 citations

One Shot of High-Dose Amikacin: A Working Hypothesis

1990 • 12 citations

Deleted Work

1955 • 0 citations

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