Synergistic Effect of Cyclosporin A and Verapamil in Overcoming Vincristine Resistance of Multidrug‐resistant Cultured Human Leukemia Cells

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1979 • 912 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

1988 • 230 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Terminology in the description of drug-radiation interactions

1979 • 177 citations

Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma

1986 • 147 citations

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.

1989 • 138 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

1988 • 105 citations

Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells.

1987 • 97 citations

Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture.

1988 • 89 citations

Treatment of acute graft-versus-host disease after allogeneic marrow transplantation. Randomized study comparing corticosteroids and cyclosporine

1985 • 79 citations

Restored in vitro sensitivity of adriamycin- and vincristine-resistant P388 leukemia with reserpine

1981 • 58 citations

Enhanced cytotoxicity against colon carcinoma by combinations of noncompeting monoclonal antibodies to the 17-1A antigen.

1988 • 53 citations

Interaction of calcium blockers and cyclosporine.

1988 • 48 citations

Correction of altered plasma membrane potentials

1988 • 47 citations

Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells

1988 • 46 citations

Enhancement of etoposide-induced cytotoxicity by cyclosporin A

1986 • 45 citations

Reversal of multidrug resistance by synthetic isoprenoids in the KB human cancer cell line.

1986 • 44 citations

Antitumor Drug Resistance

1984 • 41 citations

Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells.

1987 • 28 citations

Effects of verapamil on in vitro intracellular accumulation and retention of daunorubicin in blast cells from patients with acute nonlymphocytic leukemia

1986 • 23 citations

Multidrug Resistance in Cultured Human Leukemia and Lymphoma Cell Lines Detected by a Monoclonal Antibody, MRK16

1989 • 22 citations

Targeted blood levels of cyclosporin for cardiac transplantation.

1984 • 16 citations

Targeted blood levels of cyclosporine for cardiac transplantation

1984 • 10 citations

Influence of fetal calf serum on growth-inhibitory activity of human recombinant gamma-interferon (GI-3) in vitro.

1986 • 8 citations