Talin: Biochemistry and Cell Biology

Measurement of protein-binding phenomena by gel filtration

1962 • 1,275 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells

1979 • 794 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

The molecular structure of human erythrocyte spectrin

1979 • 539 citations

The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectin.

1985 • 503 citations

An interaction between vinculin and talin

1984 • 442 citations

Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes

1985 • 426 citations

Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin

1980 • 406 citations

A rapid purification of alpha-actinin, filamin, and a 130,000-dalton protein from smooth muscle.

1980 • 395 citations

A new protein of adhesion plaques and ruffling membranes.

1983 • 395 citations

Co-existence of vinculin and a vinculin-like protein of higher molecular weight in smooth muscle.

1982 • 343 citations

Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin

1982 • 341 citations

Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks.

1981 • 340 citations

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures.

1984 • 324 citations

A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.

1984 • 303 citations

An F-actin- and calmodulin-binding protein from isolated intestinal brush borders has a morphology related to spectrin

1982 • 276 citations

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1987 • 274 citations

Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+.

1977 • 274 citations

Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes.

1985 • 236 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

Molecular heterogeneity of adherens junctions.

1985 • 200 citations

Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments

1981 • 188 citations

Expression of transformation-associated protease(s) that degrade fibronectin at cell contact sites.

1984 • 184 citations

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.

1987 • 177 citations

A transmembrane relationship between fibronectin and vinculin (130 kd protein): Serum modulation in normal and transformed hamster fibroblasts

1981 • 157 citations

Talin at myotendinous junctions.

1986 • 155 citations

Reorganization of actin filament bundles in living fibroblasts.

1984 • 146 citations

Fibronectin-degrading proteases from the membranes of transformed cells

1987 • 134 citations

Detection of vinculin-binding proteins with an 125I-vinculin gel overlay technique.

1983 • 129 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

Identification of talin as a major cytoplasmic protein implicated in platelet activation

1985 • 121 citations

The role of phosphorylation and limited proteolytic cleavage of talin and vinculin in the disruption of focal adhesion integrity

1989 • 120 citations

Properties of smooth muscle vinculin.

1984 • 116 citations

Evidence for an actin-containing cytoplasmic precursor of the focal contact and the timing of incorporation of vinculin at the focal contact.

1987 • 102 citations

Properties of talin from chicken gizzard smooth muscle.

1987 • 96 citations

Purification and properties of human platelet P235. A high molecular weight protein substrate of endogenous calcium-activated protease(s).

1982 • 93 citations

Phosphorylation of the cytoskeletal protein talin by protein kinase C

1986 • 93 citations

A precursor of the focal contact in cultured fibroblasts

1988 • 90 citations

Reorganization of cytoskeletal and contractile elements during transition of human monocytes into adherent macrophages.

1982 • 85 citations

A re-examination of the interaction of vinculin with actin.

1986 • 85 citations

Localization of talin in skeletal and cardiac muscles

1986 • 73 citations

Interaction of tumour promoters with epithelial cells in culture

1985 • 71 citations

Talin is a post-synaptic component of the rat neuromuscular junction

1986 • 67 citations

Alpha-actinin-containing aggregates in transformed cells are highly dynamic structures.

1987 • 61 citations

Detection of high molecular weight vinculin binding proteins in muscle and nonmuscle tissues with an electroblot-overlay technique

1983 • 60 citations

Isolation and characterization of a vinculin cDNA from chick-embryo fibroblasts

1987 • 50 citations

Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry.

1988 • 49 citations

Platelet protein organization: analysis by treatment with membrane- permeable cross-linking reagents

1982 • 47 citations

Calcium-dependent proteins in platelets response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agents

1980 • 47 citations

Effects of local anesthetics on human platelets: filopodial suppression and endogenous proteolysis

1979 • 45 citations

Human platelet P235: A high M_r protein which restricts the length of actin filaments

1982 • 40 citations

The relationship between talin and acetylcholine receptor clusters in Xenopus muscle cells

1989 • 29 citations

Vinculin interaction with permeabilized cells: disruption and reconstitution of a binding site.

1986 • 28 citations

Purification and characterization of a protein from chicken gizzard, which inhibits actin polymerization

1985 • 25 citations

Purification of a 190 kDa protein from smooth muscle: relationship to talin

1986 • 24 citations