Metabolism of [1-14C] — arachidonic acid by cultured calf aortic endothelial cells: Evidence for the presence of a lipoxygenase pathway

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

1980 • 330 citations

Leukotrienes and other Lipoxygenase Products

1983 • 319 citations

Bovine endothelial cells in culture produce thromboxane as well as prostacyclin.

1981 • 300 citations

15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase.

1980 • 195 citations

Double dioxygenation of arachidonic acid by soybean lipoxygenase-1 kinetics and regio-stereo specificities of the reaction steps

1981 • 180 citations

Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient rats

1980 • 143 citations

Lipid biochemical preparations

1981 • 135 citations

Selective inhibition of platelet n — 8 lipoxygenase by 5,8,11-eicosatriynoic acid

1977 • 118 citations

The production of the arachidonate metabolite HETE in vascular tissue

1979 • 115 citations

New role for 15-hydroxyeicosatetraenoic acid. Activator of leukotriene biosynthesis in PT-18 mast/basophil cells.

1982 • 109 citations

Lipoxygenase activity in rat kidney glomeruli, glomerular epithelial cells, and cortical tubules.

1982 • 106 citations

Calcium dependency of aortic smooth muscle cell migration induced by 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid

1983 • 97 citations

Evidence for inhibition of leukotriene A4 synthesis by 5,8,11,14-eicosatetraynoic acid in guinea pig polymorphonuclear leukocytes.

1981 • 93 citations

The inhibitory effects of BW 755C on arachidonic acid metabolism in human polymorphonuclear leukocytes

1980 • 79 citations

Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells.

1980 • 64 citations

The role of arachidonate lipoxygenase and fatty acids during irreversible blood platelet aggregation in vitro

1981 • 60 citations

Formation of 6-oxoprostaglandin F1 alpha, 6,15-dioxoprostaglandin F1 alpha, and monohydroxyicosatetraenoic acids from arachidonic acid by fetal calf aorta and ductus arteriosus.

1982 • 46 citations

The isomeric compositions of hydroperoxides produced by oxidation of arachidonic acid with singlet oxygen.

1981 • 32 citations

Reticulocyte lipoxygenase exhibits both n‐6 and n‐9 activities

1983 • 29 citations

Role of lipoxygenase in the O2-dependent activation of soluble guanylate cyclase from rat lung

1982 • 17 citations

Arachidonate metabolism in the mouse thyroid implication of the lipoxygenase pathway in thyrotropin action

1981 • 15 citations

Evidence for the presence of lipoxygenase pathway in cultured endothelial cells.

1983 • 14 citations

Endogenous arachidonic acid metabolism by cultured arterial smooth muscle cells

1981 • 12 citations

Purification and properties of arachidonate-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes.

1982 • 4 citations

Isolation of an enzyme system in rat lung cytosol which converts arachidonic acid into 8,11,12-trihydroxyeicosatrienoic acid.

1982 • 4 citations