Regulatory mechanisms in inflammation: New aspects of autopharmacology

THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1

1946 • 2,239 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

The effective period of preventive antibiotic action in experimental incisions and dermal lesions.

1961 • 1,301 citations

Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

1977 • 1,284 citations

DIRECT EVIDENCE FOR NEUROGENIC INFLAMMATION AND ITS PREVENTION BY DENERVATION AND BY PRETREATMENT WITH CAPSAICIN

1967 • 1,100 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Temporary Abolition of Pain in Man

1967 • 931 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

The Effect of a Hormone of the Adrenal Cortex (17-hydroxy-11-dehydrocorticosterone: Compound E) and of Pituitary Adrenocorticotropic Hormone on Rheumatoid Arthritis

1949 • 781 citations

Chemotaxis of Polymorphonuclear Leukocytes from Patients with Diabetes Mellitus

1971 • 727 citations

EFFECTS OF CORTISONE ACETATE AND PITUITARY ACTH ON RHEUMATOID ARTHRITIS, RHEUMATIC FEVER AND CERTAIN OTHER CONDITIONS

1950 • 491 citations

On the origin from the spinal cord of the vaso‐dilator fibres of the hind‐limb, and on the nature of these fibres1

1901 • 480 citations

A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*

1967 • 396 citations

The value and duration of defence reactions of the skin to the primary lodgement of bacteria.

1957 • 378 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

ACTIVATION OF HAGEMAN FACTOR IN SOLID AND FLUID PHASES

1973 • 346 citations

The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system

1978 • 337 citations

A Neutrophil Chemotactic Factor from Human C′5

1969 • 297 citations

THE ROLE OF SENSORY NERVE ENDINGS IN NEUROGENIC INFLAMMATION INDUCED IN HUMAN SKIN AND IN THE EYE AND PAW OF THE RAT

1968 • 284 citations

Reactions of denervated voluntary muscle, and their bearing on the mode of action of parasympathetic and related nerves

1930 • 264 citations

Effects of Adrenergic and Cholinergic Agents Upon Insulin Secretionin Vitro

1967 • 259 citations

Impaired Granulocyte Adherence: A Reversible Defect in Host Defense in Patients with Poorly Controlled Diabetes

1978 • 253 citations

THE EFFECTS OF ADRENALECTOMY AND HYPOPHYSECTOMY UPON EXPERIMENTAL DIABETES IN THE CAT

1936 • 248 citations

Adrenocortical Hormone in Arthritis : Preliminary Report

1949 • 201 citations

THE INFLUENCE OF THE ADRENAL CORTEX ON BEHAVIOR OF TERMINAL VASCULAR BED

1953 • 201 citations

BIOLOGICAL ACTIVITY OF COMPLEMENT IN VIVO

1971 • 185 citations

PREKALLIKREIN DEFICIENCY IN MAN

1973 • 175 citations

Stimulation of Glucagon Secretion by Epinephrine in Man

1973 • 163 citations

Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating

1973 • 154 citations

Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin

1969 • 152 citations

Nociceptive threshold after neonatal capsaicin treatment

1979 • 139 citations

The Nature and the Distribution of Afferent Fibres Provided with the Axon Reflex Arrangement

1953 • 137 citations

Anaphylatoxin in Its Relation to the Complement System

1967 • 129 citations

THE PASSAGE OF COLLOIDAL PARTICLES ACROSS THE DERMAL CAPILLARY WALL UNDER THE INFLUENCE OF HISTAMINE

1959 • 115 citations

Anti-edema and analgesic properties of delta9-tetrahydrocannabinol (THC).

1973 • 115 citations

STUDIES ON THE EFFECT OF EXPERIMENTAL NONKETOTIC DIABETES MELLITUS ON ANTIBACTERIAL DEFENSE

1966 • 114 citations

The role of adrenocortical steroids in infection, immunity and hypersensitivity.

1956 • 112 citations

Leukocyte chemotaxis in diabetic patients and their nondiabetic first-degree relatives.

1976 • 111 citations

The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf

1973 • 107 citations

Chemical Mediators. I

1965 • 102 citations

Cyclic nucleotides and modulation of effector systems of inflammation

1974 • 95 citations

Neurohumoral Features of Afferent Fibers in Man

1961 • 93 citations

Induced Synthesis of Histamine, Microcirculatory Regulation and the Mechanism of Action of the Adrenal Glucocorticoid Hormones

1963 • 86 citations

The enhancement of infection during shock produced by bacterial toxins and other agents.

1950 • 75 citations

Effect of Adrenaline and Glucose on Release of Glucagon and Insulin in vitro

1971 • 68 citations

Impaired granulocyte adherence. A reversible defect in host defense in patients with poorly controlled diabetes

1978 • 68 citations

Inhibition of Histamine Release in Experimental Diabetes

1957 • 65 citations

Injury, Inflammation, and Immunity

1962 • 64 citations

Site of action of endotoxins on hypothalamic-pituitary-adrenal axis

1971 • 64 citations

Influence of diabetes upon the inflammatory response of the rat. A pharmacological analysis

1973 • 63 citations

THE PARTICIPATION OF THE NERVOUS SYSTEM IN THE INFLAMMATORY REACTION

1964 • 61 citations

NONSPECIFIC DEFENSE REACTIONS IN BACTERIAL INFECTIONS

1956 • 59 citations

The Acute Effect of Insulin on Capillary Endothelial Cells

1978 • 59 citations

ULTRASTRUCTURE OF THE A-CELLS OF CAT ISLETS OF LANGERHANS FOLLOWING SYMPATHETIC STIMULATION OF GLUCAGON SECRETION

1970 • 55 citations

In vivo observations of the effects of cortisone upon the blood vessels in rabbits ear chambers.

1952 • 54 citations

Pituitary ACTH and Plasma Free Corticosteroids Following Bilateral Adrenalectomy in the Rat.

1959 • 52 citations

Anaphylatoxin Formation by Purified Human C′1 Esterase

1965 • 50 citations

On the mechanism of scorpion toxin-induced release of norepinephrine from peripheral adrenergic neurons.

1974 • 50 citations

The effects of adrenalectomy and corticosterone on vascular permeability responses in the skin of the rat.

1975 • 49 citations

The Correlation between the Stimulation Frequency and the Dilator Response Evoked by ‘Antidromic’ Excitation of the Thin Afferent Fibres in the Dorsal Roots

1953 • 49 citations

Possible participation of insulin in the control of vascular permeability

1974 • 46 citations

Studies of the cortisone effects on the inflammatory response. 1. Alterations of the histopathology of chemically induced inflammation.

1952 • 42 citations

STIMULATION OF THE HYPOTHALAMO‐PITUITARY‐ADRENAL AXIS BY COMPOUNDS FORMED IN INFLAMED TISSUE

1975 • 40 citations

Preoperative Antibiotics

1963 • 38 citations

The inflammatory response to carrageenan

1975 • 38 citations

Endogenous Modulators of the Inflammatory Response

1978 • 37 citations

FORMATION OF A FACTOR INCREASING VASCULAR PERMEABILITY DURING ELECTRICAL STIMULATION OF THE SAPHENOUS NERVE IN RATS

1974 • 34 citations

INHIBITORY EFFECTS OF CARBOHYDRATES ON HISTAMINE RELEASE AND MAST CELL DISRUPTION BY DEXTRAN

1962 • 34 citations

Relationship between oedema and plasma exudation in rat paw carrageenin inflammation

1978 • 32 citations

SENSITIZATION BY INSULIN TO THE DEXTRAN "ANAPHYLACTOID" REACTION

1957 • 31 citations

STUDIES ON GRANULATION TISSUE PRODUCTION IN ALLOXAN-DIABETIC RATS

1961 • 31 citations

The Beta Cell and Its Responses: Summarizing Remarks and Some Contributions from Geneva

1972 • 30 citations

Decreased vascular reactions to permeability factors in experimental diabetes.

1976 • 30 citations

Vasoconstriction in the Cheek Pouch of the Hamster Following Treatment With Cortisone

1954 • 29 citations

Diabetes and Neutrophil Chemotaxis

1977 • 27 citations

Effect of Cortisone upon Local Capillary Permeability

1954 • 20 citations

MEDIATION OF INCREASED VASCULAR PERMEABILITY IN INFLAMMATION

1973 • 20 citations

Mechanisms of pain and analgesic compounds

1978 • 19 citations

Paper-chromatographic study of the secretion of the adrenal cortex in various mammalian species.

1951 • 18 citations

Sensory nerves and inflammation: Evidence for the release of a neurogenic permeability factor by Tityustoxin

1978 • 15 citations

Diabetes and neutrophil chemotaxis

1977 • 14 citations

THE RESPONSE OF NORMAL, HYPOPHYSECTOMISED AND ADRENALECTOMISED RATS TO HISTAMINE ADMINISTRATION

1941 • 14 citations

RESISTANCE OF THE RAT TO HISTAMINE SHOCK AFTER DESTRUCTION OF THE ADRENAL MEDULLA

1936 • 14 citations

The Organ of Langerhans in New Perspective

1970 • 13 citations

ANTI‐INFLAMMATORY ACTION OF GLUCAGON IN RATS

1975 • 10 citations

CORTICAL POTENTIALS EVOKED BY NOCICEPTIVE STIMULI: THEIR DEPRESSION BY A FACTOR RELEASED DURING SAPHENOUS NERVE STIMULATION IN THE RAT

1974 • 10 citations

The haemorrhagic exudate and its possible relationship to neurogenic inflammation

1980 • 9 citations

Endocrine Aspects of Disease Processes.

1969 • 9 citations

Participation of sensory nervous structures in the development of inflammatory reactions.

1977 • 7 citations

Blood Sugar Levels and Allergies

1968 • 5 citations