Mechanisms of initiation and perpetuation of gut inflammation by stress

Psychological Stress and Susceptibility to the Common Cold

1991 • 1,679 citations

Slowing of wound healing by psychological stress

1995 • 1,096 citations

A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease

1989 • 1,087 citations

Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.

1995 • 836 citations

Psychosocial Modifiers of Immunocompetence in Medical Students

1984 • 793 citations

The role of psychological and biological factors in postinfective gut dysfunction

1999 • 777 citations

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

1986 • 731 citations

Quality of life: A valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease

1994 • 703 citations

A new measure of health status for clinical trials in inflammatory bowel disease

1989 • 653 citations

Suppression of Lymphocyte Stimulation Following Bereavement

1983 • 628 citations

Intestinal permeability and the prediction of relapse in Crohn's disease

1993 • 621 citations

Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention

2000 • 590 citations

Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves.

1987 • 554 citations

Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo

1991 • 485 citations

Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys

1999 • 456 citations

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

1995 • 444 citations

Corticotropin-Releasing Hormone Induces Skin Mast Cell Degranulation and Increased Vascular Permeability, A Possible Explanation for Its Proinflammatory Effects*

1998 • 426 citations

Stress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission

2000 • 426 citations

Level of chronic life stress predicts clinical outcome in irritable bowel syndrome

1998 • 406 citations

Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.

1992 • 362 citations

Is small intestinal permeability really increased in relatives of patients with Crohn's disease?

1993 • 323 citations

Clustering of increased small intestinal permeability in families with Crohn's disease

1997 • 264 citations

Environmental stress–induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat

2000 • 262 citations

The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis

1999 • 255 citations

Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells

1996 • 249 citations

Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat

1999 • 246 citations

Release of mast cell mediators into the jejunum by cold pain stress in humans

1998 • 231 citations

Tachykinins in the gut. Part II. Roles in neural excitation, secretion and inflammation

1997 • 230 citations

Stress stimulates transepithelial macromolecular uptake in rat jejunum

1998 • 226 citations

Stress-induced intracranial mast cell degranulation: a corticotropin- releasing hormone-mediated effect

1995 • 225 citations

Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine

1994 • 215 citations

Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells

2000 • 205 citations

Psychological stress and disease activity in ulcerative colitis: a multidimensional cross-sectional study.

1994 • 190 citations

Corticotropin‐Releasing Factor and the Brain‐Gut Motor Response to Stress

1999 • 184 citations

Why do patients with ulcerative colitis relapse?

1990 • 183 citations

The Influence of Psychological Stress on the Immune Response to Vaccines^a

1998 • 179 citations

Illness Experience and Life Stresses in Patients with Irritable Colon and with Ulcerative Colitis

1970 • 178 citations

Relevance of Major Stress Events as an Indicator of Disease Activity Prevalence in Inflammatory Bowel Disease

1991 • 177 citations

A study of the association between Crohn's disease and psychiatric illness

1984 • 176 citations

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P

1999 • 174 citations

Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease

1996 • 172 citations

Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation.

1991 • 165 citations

Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?

1991 • 162 citations

Personality profile and affective state of patients with inflammatory bowel disease.

1989 • 157 citations

Inhibition of Mantoux Reaction by Direct Suggestion under Hypnosis

1963 • 153 citations

RENAL BIOPS IN CHILDREN.

1965 • 153 citations

Stimulatory effect of corticotropin-releasing neurohormone on human lymphocyte proliferation and interleukin-2 receptor expression

1989 • 151 citations

Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.

1995 • 150 citations

Previous inflammation alters the response of the rat colon to stress

1996 • 150 citations

Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers

1993 • 146 citations

Evaluation of a psychological treatment for inflammatory bowel disease

1991 • 137 citations

Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes

1990 • 136 citations

Interleukin-6 expression and regulation in rat enteric glial cells

2001 • 136 citations

Quantification of the placebo response in ulcerative colitis

1997 • 134 citations

Beneficial effects of local or systemic lidocaine in experimental colitis

1994 • 132 citations

A controlled study of the association between ulcerative colitis and psychiatric diagnoses

1982 • 131 citations

Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF

1999 • 127 citations

Major histocompatibility class II expression on the small intestinal nervous system in Crohn's disease

1992 • 127 citations

Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord

1983 • 126 citations

A stress management programme for inflammatory bowel disease patients

1986 • 123 citations

Quality of life in inflammatory bowel disease: the interaction of disease activity with psychosocial function.

1995 • 120 citations

Local secretion of corticotropin-releasing hormone by enterochromaffin cells in human colon

1994 • 117 citations

Cholinergic nerves mediate stress-induced intestinal transport abnormalities in Wistar-Kyoto rats

1997 • 117 citations

Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine

1993 • 110 citations

Corticotropin-Releasing Factor Receptors in Mouse Spleen: Identification of Receptor-Bearing Cells as Resident Macrophages

1990 • 109 citations

Rectal Mucosal Adrenergic Innervation and Enterochromaffin Cells in Ulcerative Colitis and Irritable Colon

1977 • 108 citations

Effect of psychological stress on salt and water transport in the human jejunum

1987 • 108 citations

The Influence of Mast Cells on Pathways of Transepithelial Antigen Transport in Rat Intestine

1998 • 107 citations

Colonic mucin release in response to immobilization stress is mast cell dependent

1998 • 106 citations

Long-term monitoring of psychosocial stress and symptomatology in inflammatory bowel disease

1994 • 104 citations

CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability

1995 • 103 citations

Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease

1997 • 98 citations

Psychiatric study of a consecutive series of 34 patients with ulcerative colitis.

1967 • 98 citations

Effect of Psychotherapy on the Course of Crohn's Disease: Results of the German Prospective Multicenter Psychotherapy Treatment Study on Crohn's Disease

1998 • 94 citations

Novel Intestinal Helicobacter Species Isolated from Cotton-Top Tamarins ( Saguinus oedipus ) with Chronic Colitis

1999 • 94 citations

The effect of dexamethasone administration on rat intestinal permeability: The role of bacterial adherence

1994 • 86 citations

A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats.

1996 • 82 citations

Psychological distress and levels of disease activity in inflammatory bowel disease.

1994 • 71 citations

Large Bowel Disorders

1976 • 71 citations

Coexistence of glucocorticoid receptor-like immunoreactivity with neuropeptides in the hypothalamic paraventricular nucleus

1989 • 70 citations

The “Natural History” of Ulcerative Colitis

1989 • 67 citations

Neurotensin Activates Tuberoinfundibular Dopamine Neurons and Increases Serum Corticosterone Concentrations in the Rat

1989 • 67 citations

Characteristics of the intestinal epithelial barrier during dietary manipulation and glucocorticoid stress

1996 • 66 citations

Glucocorticoid regulation of the humoral immune system. I. In vivo effects of dexamethasone on IgA and IgG in serum and at mucosal surfaces.

1990 • 65 citations

Modulation of immune response to rDNA hepatitis B vaccination by psychological stress

1996 • 62 citations

Evidence that colitis is initiated by environmental stress and sustained by fecal factors in the cotton-top tamarin (Saguinus oedipus).

2000 • 58 citations

Hematology and immunology studies: the second manned Skylab mission.

1976 • 58 citations

Relapse-Precipitating Life Events and Feelings in Patients with Inflammatory Bowel Disease

1992 • 57 citations

The Treatment of Ulcerative Colitis

1954 • 56 citations

Local production of corticotropin releasing hormone is increased in experimental intestinal inflammation in rats.

1996 • 55 citations

The Treatment of Ulcerative Colitis. II

1954 • 50 citations

Psychotherapeutic Interventions in Alexithymic Patients

1985 • 48 citations

Lag Time between Stress Events and Risk of Recurrent Episodes of Inflammatory Bowel Disease

1991 • 47 citations

Ulcerative Colitis-Like Lesion in Siamang Gibbons

1969 • 47 citations

Psychosocial factors in inflammatory bowel disease.

1995 • 46 citations

Both crypt and villus intestinal goblet cells secrete mucin in response to cholinergic stimulation

1992 • 46 citations

The Response to Psychotherapy in Chronic Ulcerative Colitis

1968 • 45 citations

Relapsing ulcerative colitis associated with spinal cord stimulation

1999 • 45 citations

NON-SPECIFIC ULCERATIVE COLITIS IN BEDOUIN ARABS

1967 • 45 citations

Neurotensin stimulates Cl− secretion in human colonic mucosa in vitro: Role of adenosine

2000 • 45 citations

Stress‐Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activation

2000 • 44 citations

A Gut Reaction--Lymphoepithelial Communication in the Intestine

1997 • 33 citations

Corticotropin-releasing factor is contained within perikarya and nerve fibres of rat duodenum

1984 • 32 citations

Involvement of central dopamine and D1 receptors in stress-induced colonie motor alterations in rats

1992 • 29 citations

The Clinical Course and Prognostic Determinants of the Irritable Bowel Syndrome: A Literature Review

1998 • 29 citations

Advances in Psychoneuroimmunology

1994 • 26 citations

Central Administration of Neurotensin Stimulates Hypothalamic‐Pituitary‐Adrenal Activity

1992 • 26 citations

PSYCHOSOCIAL FACTORS IN INFLAMMATORY BOWEL DISEASE

1995 • 25 citations

Psychological factors in ulcerative colitis in man and gibbon.

1969 • 25 citations

The Response to Psychotherapy in Chronic Ulcerative Colitis

1969 • 24 citations

ONSET SETTING IN INFLAMMATORY BOWEL DISEASE

1974 • 22 citations

Relationship between structure and function of liver mitochondria from hibernating and active ground squirrels, Citellus undulatus

1993 • 22 citations

A Double Standard for Psychosomatic Papers?

1973 • 22 citations

Profuse bleeding from a duodenal diverticulum.

1994 • 22 citations

Row replacement algorithms for screen editors

1989 • 21 citations

The role of the neurotransmitters acetylcholine and noradrenaline in the pathogenesis of stress ulcers

1993 • 11 citations

An objective study of psychological factors in ulcerative colitis in children.

1965 • 8 citations

New trends in psychosomatic research.

1977 • 8 citations

Placebos in medicine.

1999 • 8 citations

Social stress induces reversible inflammation and persistent epithelial barrier dysfunction in the rat intestine

2001 • 6 citations

Psychological and Neural Regulation of Intestinal Hypersensitivity

1994 • 5 citations

Early maternal deprivation predisposes adult rats to colonic mucosal barrier dysfunction in response to mild stress

2001 • 3 citations

Chronic psychological stress induces epithelial barrier disruption, bacterial penetration, and mucosal inflammation in ileum and colon of naïve rats

2001 • 3 citations

Chronic psychological stress induces mucosal inflammation in the ileum and colon of Naïve rats: Role of mast cells

2001 • 3 citations

Urocortin and corticotropin-releasing factor (CRF) receptor type 1 mRNA are expressed in the rat colon

2001 • 2 citations

High-Level Care of a Twin Infant by a Male Rhesus Macaque

1992 • 2 citations

Mast cell histamine mediates neurotensin-enhanced 3H-taurocholate absorption in jejunum

2001 • 2 citations

Chronic psychological stress induces mucosal inflammation in the ileum and colon of Naïve rats: Role of mast cells

2001 • 1 citations