Sodium pump inhibition, enhanced calcium influx via sodium-calcium exchange, and positive inotropic response in cultured heart cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The dependence of calcium efflux from cardiac muscle on temperature and external ion composition

1968 • 1,024 citations

The influence of calcium on sodium efflux in squid axons

1969 • 961 citations

Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle.

1981 • 572 citations

Calcium transients in aequorin-injected frog cardiac muscle

1978 • 441 citations

Stoichiometry of sodium-calcium exchange in cardiac sarcolemmal vesicles. Coupling to the sodium pump.

1979 • 407 citations

The generation of electric currents in cardiac fibers by Na/Ca exchange

1979 • 399 citations

Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development.

1982 • 332 citations

The effect of the internal sodium concentration on calcium fluxes in isolated guinea‐pig auricles

1970 • 328 citations

The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres

1977 • 307 citations

Enhancement of calcium current during digitalis inotrophy in mammalian heart: positive feed‐back regulation by intracellular calcium?

1982 • 214 citations

Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride.

1984 • 186 citations

Sodium-calcium exchange in regulation of cardiac contractility. Evidence for an electrogenic, voltage-dependent mechanism.

1979 • 185 citations

Effects of strophanthidin upon contraction and ionic exchange in rabbit ventricular myocardium: Relation to control of active state

1970 • 178 citations

The dependence of sodium pumping and tension on intracellular sodium activity in voltage‐clamped sheep Purkinje fibres.

1981 • 159 citations

Mechanisms of transmembrane calcium movement in cultured chick embryo ventricular cells

1982 • 131 citations

The control of tonic tension by membrane potential and intracellular sodium activity in the sheep cardiac Purkinje fibre.

1983 • 130 citations

Relation between intracellular Na ion activity and tension of sheep cardiac Purkinje fibers exposed to dihydro-ouabain

1980 • 130 citations

Intracellular Ca²⁺ transients in the cat papillary muscle

1982 • 105 citations

Inotropic effects and changes in sodium and calcium contents associated with inhibition of monovalent cation active transport by ouabain in cultured myocardial cells.

1979 • 104 citations

Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers.

1980 • 103 citations

Is digitalis inotropy associated with enhanced slow inward calcium current?

1978 • 98 citations

Is the cell membrane Na+, K+ -ATPase enzyme system the pharmacological receptor for digitalis?

1976 • 93 citations

An effect of ouabain on the superficially-located stores of calcium in cardiac muscle cells

1973 • 70 citations

Potential and tension changes induced by sodium removal in dog Purkinje fibres: role of an electrogenic sodium-calcium exchange.

1981 • 69 citations

Intracellular [Ca2+] transients in voltage clamped cardiac Purkinje fibers

1982 • 61 citations

Kinetic studies on sodium-dependent calcium uptake by myocardial cells and neuroblastoma cells in culture

1981 • 60 citations

Two classes of ouabain receptors in chick ventricular cardiac cells and their relation to (Na+,K+)-ATPase inhibition, intracellular Na+ accumulation, Ca2+ influx, and cardiotonic effect.

1983 • 56 citations

Uphill Sodium Transport Driven by an Inward Calcium Gradient in Heart Muscle

1983 • 50 citations

Activation of the electrogenic sodium pump in guinea‐pig atria by external potassium ions

1978 • 48 citations

The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres

1982 • 41 citations

Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechanisms

1984 • 34 citations

Sodium dependence of the inotropic effect of a reduction in extracellular potassium concentration

1971 • 31 citations

Involvement of an Na+_Ca2+ exchange system in genesis of ouabain-induced arrhythmias of cultured myocardial cells

1981 • 27 citations

Movement of Ca2+ across the sarcolemma: Effects of abrupt exposure to zero external Na concentration

1984 • 22 citations

Influence of cell dissociation and culture of chick embryo ventricle on inotropic responses to calcium and lanthanum

1978 • 17 citations

Evidence that concentrations of ouabain which induce positive inotropic effects on the perfused guinea-pig heart increase the amount of calcium in a rapidly-exchangeable cellular compartment

1982 • 5 citations

The role of superficially bound calcium in the regulation of myocardial contractility and the positive inotropic response to ouabain

1982 • 5 citations