Low Molecular Weight, Sequence Based, Collagenase Inhibitors Selectively Block the Interaction Between Collagenase and TIMP (Tissue Inhibitor of Metalloproteinases)

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Methods of Enzymatic Analysis

1974 • 6,512 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen

1979 • 350 citations

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor.

1978 • 264 citations

A rapid and simple spectrophotometric assay of angiotensin-converting enzyme

1978 • 199 citations

The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor

1983 • 172 citations

Synthetic substrates for vertebrate collagenase

1977 • 142 citations

Collagenase Inhibitors: Their Design and Potential Therapeutic Use

1987 • 121 citations

A highly sensitive fluorometric assay for “enkephalinase”, a neutral metalloendopeptidase that releases tyrosine-glycine-glycine from enkephalins

1984 • 118 citations

Human alpha-1-proteinase inhibitor mechanism of action: Evidence for activation by limited proteolysis

1976 • 103 citations

A new synthetic inhibitor of mammalian tissue collagenase inhibits bone resorption in culture

1985 • 98 citations

Purification of pig synovial collagenase to high specific activity

1979 • 91 citations

Identification and partial characterization of an inhibitor of collagenase from rabbit bone

1977 • 90 citations

Collagenase and rheumatoid arthritis

1970 • 89 citations

Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor

1989 • 76 citations

Absolute steric course of hydrolysis by .alpha.-chymotrypsin. Esters of .alpha.-benzylsuccinic, .alpha.-methyl-.beta.-phenylpropionic, and .alpha.-methylsuccinic acids

1968 • 60 citations

Purification and properties of a collagenase inhibitor from cultures of bovine aorta

1980 • 31 citations

An inhibitor of mammalian collagenase active at micromolar concentrations from an Actinomycete culture broth.

1987 • 15 citations

Alpha2-Macroglobulin in Connective Tissue Matrix Metabolism

1984 • 13 citations

[Inhibition of synovial collagenase by actinonin. Study of structure/activity relationship].

1989 • 12 citations

Zur Kenntnis der Aminosäurearylamidasen

1971 • 12 citations

Monoclonal Antibodies Against Synovial Collagenase: Use for Immunopurification and Characterization of the Latent and Active Enzyme

1988 • 6 citations

Molecular Cloning and Synthesis of Biologically Active Human Tissue Inhibitor of Metalloproteinases in Yeast

1987 • 5 citations

[Natural inhibitor of metalloproteinases: structural and functional study].

1989 • 5 citations

Deleted Work

1955 • 0 citations