Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Mechanism of inhibition of cell proliferation by Vinca alkaloids.

1991 • 534 citations

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

1991 • 363 citations

DNA STRAND BREAKS OCCURRING DURING APOPTOSIS - THEIR EARLY INSITU DETECTION BY THE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE AND NICK TRANSLATION ASSAYS AND PREVENTION BY SERINE PROTEASE INHIBITORS

1992 • 253 citations

Single‐step procedure for labeling DNA strand breaks with fluorescein‐ or Bodipy‐conjugated deoxynucleotides: Detection of apoptosis and bromodeoxyuridine incorporation

1995 • 178 citations

G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.

1993 • 162 citations

p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth.

1997 • 88 citations

Isohomohalichondrin B, a new antitumour polyether macrolide from the New Zealand deep-water sponge Lissodendoryx sp.

1994 • 73 citations

Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin

1993 • 69 citations

Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15

1996 • 54 citations

Discrimination of G2 and Mitotic Cells by Flow Cytometry Based on Different Expression of Cyclins A and B1

1995 • 54 citations

Accumulation of HL-60 leukemia cells in G2/M and inhibition of cytokinesis caused by two marine compounds, bistratene A and cycloxazoline

1994 • 26 citations

Comparison of cell‐cycle phase perturbations induced by the DNA‐minor‐groove alkylator tallimustine and by melphalan in the SW626 cell line

1995 • 24 citations

The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells.

1996 • 18 citations

Characterization of cyclin B1 expression in human cancer cell lines by a new three-parameter BrdUrd/Cyclin B1/DNA analysis

1998 • 14 citations

Block of bcr-abl expression and induction of apoptosis by cisplatinum in a human chronic myeloid leukaemia cell line

1996 • 4 citations