Ribosomal gene transcription is organized in foci within nucleolar components

Biometry: The Principles and Practice of Statistics in Biological Research (2nd ed.).

1982 • 3,776 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

1988 • 282 citations

Autoantibody to RNA polymerase I in scleroderma sera.

1987 • 241 citations

Site of transcription of ribosomal RNA and intranucleolar structure in HeLa cells

1994 • 214 citations

Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component

1996 • 182 citations

Localization of the RNA polymerase I transcription factor hUBF during the cell cycle

1993 • 178 citations

The terminal balls characteristic of eukaryotic rRNA transcription units in chromatin spreads are rRNA processing complexes.

1993 • 173 citations

Purification and characterization of the DNA untwisting enzyme from rat liver

1976 • 134 citations

On the position of nucleolus organizer regions (NORs) in interphase nuclei

1986 • 129 citations

Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongation.

1992 • 118 citations

Does the synthesis of ribosomal RNA take place‐within nucleolar fibrillar centers or dense fibrillar components?

1989 • 110 citations

Interpreting nucleolar structure: where are the transcribing genes?

1991 • 103 citations

The RNA polymerase I-specific transcription initiation factor UBF is associated with transcriptionally active and inactive ribosomal genes

1993 • 102 citations

Different patterns of rDNA organization at interphase in nuclei of wheat and rye

1992 • 96 citations

The human ribosomal RNA genes: structure and organization of the complete repeating unit

1986 • 95 citations

The RNA polymerase I transactivator upstream binding factor requires its dimerization domain and high-mobility-group (HMG) box 1 to bend, wrap, and positively supercoil enhancer DNA.

1994 • 85 citations

The nucleolar architecture of polymerase I transcription and processing.

1995 • 81 citations

Does the Synthesis of Ribosomal RNA Take Place within Nucleolar Fibrillar Centers or Dense Fibrillar Components? A Critical Appraisal

1995 • 75 citations

Ribosomal DNA is located and transcribed in the dense fibrillar component of human Sertoli cell nucleoli

1989 • 68 citations

Human ribosomal RNA gene repeats are localized in the dense fibrillar component of nucleoli: Light and electron microscopic in situ hybridization in human Sertoli cells

1992 • 60 citations

Electron microscopic in situ hybridization and autoradiography: Localization and transcription of rDNA in human lymphocyte nucleoli

1990 • 53 citations

A new approach to map transcription sites at the ultrastructural level.

1994 • 47 citations

Catching RNA Polymerase I in Flagranti: Ribosomal Genes Are Transcribed in the Dense Fibrillar Component of the Nucleolus

1995 • 46 citations

Three-dimensional reconstructions of nucleolus-organizing regions in PHA-stimulated human lymphocytes

1989 • 41 citations

Electron Microscopic Localization of Ribosomal DNA in Rat Liver Nucleoli by Nonisotopic in Situ Hybridization

1993 • 38 citations

Fibrillar center distribution in nucleoli of PHA-stimulated human lymphocytes

1989 • 38 citations

Structure-function subcompartments of the mammalian cell nucleus as revealed by the electron microscopic affinity cytochemistry

1992 • 37 citations

Behaviour of nucleolar proteins in nuclei lacking ribosomal genes: A study by confocal laser scanning microscopy

1991 • 36 citations

Nuclear architecture and ultrastructural distribution of poly(ADP-ribosyl)transferase, a multifunctional enzyme

1996 • 34 citations

Distribution of DNA in human Sertoli cell nucleoli.

1993 • 33 citations

Nucleolar organizer structure and activity in a nucleolus without fibrillar centres: the nucleolus in an established Drosophila cell line

1982 • 32 citations

Structural changes in nucleoli during inhibition of protein- and RNA-biosynthesis

1987 • 27 citations

Redistribution of ribosomal DNA after blocking of transcription induced by actinomycin D

1996 • 25 citations

Nucleolus-like morphology produced during the in vitro reassociation of nucleolar components

1993 • 23 citations

Ultrastructural rRNA localization in plant cell nucleoli. RNA/RNA in situ hybridization, autoradiography and cytochemistry

1993 • 22 citations

A Drosophila anti-rna polymerase ii antibody recognizes a plant nucleolar antigen, rna polymerase i, which is mostly localized in fibrillar centres

1991 • 21 citations

Three‐dimensional ultrastructure and quantitative analysis of the human Sertoli cell nucleolus

1988 • 20 citations

The uptake of uridine in the nucleolus occurs in the dense fibrillar component

1993 • 17 citations

Nucleolar morphology and rDNA in situ hybridisation in monocytes

1992 • 17 citations

Revealing nucleolar architecture by low ionic strength treatment

1992 • 16 citations

Immunoelectron Microscopy of RNA Combined with Nucleic Acid Cytochemistry in Plant Nucleoli

1994 • 16 citations

Intranucleolar localization of the RNA polymerase A activity in isolated nuclei of regenerating rat liver*1

1978 • 16 citations

Distribution of B-36 nucleolar protein in relation to transcriptional activity in plant cells

1992 • 15 citations

Distribution of fibrillar centers and silver‐stained components in the nucleolus of human Sertoli cells

1984 • 14 citations

Ultrastructural localization of rDNA and rRNA by in situ hybridization in the nucleolus of human spermatids

1994 • 14 citations

Detection of anti-topoisomerase I antibodies using a full length human topoisomerase I recombinant protein purified from a baculovirus expression system

1995 • 12 citations

Post-mitotic assembly of the nucleolus. I. The internal matrix network is a recruitment site for processing nucleolar components in prenucleolar bodies

1996 • 6 citations

Nucleolar organization as revealed in cycloheximide treated cells

1994 • 3 citations