Does a Placebo Run-In or a Placebo Treatment Cell Affect the Efficacy of Antidepressant Medications?

ECDEU Assessment Manual for Psychopharmacology

1976 • 8,729 citations

A Rating Scale for Depression

1960 • 1,338 citations

Antidepressant Specificity in Atypical Depression

1988 • 344 citations

Antidepressant efficacy of sertraline: a double-blind, placebo- and amitriptyline-controlled, multicenter comparison study in outpatients with major depression.

1990 • 261 citations

A Comparison of Fluoxetine Imipramine and Placebo in Patients with Bipolar Depressive Disorder

1989 • 256 citations

Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders

1988 • 195 citations

A Multiple-Dose, Controlled Study of Phenelzine in Depression-Anxiety States

1976 • 122 citations

A comparative clinical trial of fluoxetine, mianserin and placebo in depressed outpatients

1988 • 112 citations

Which depressions respond to placebo?

1986 • 109 citations

Pharmacologic treatment of major depression for elderly patients in residential care settings.

1990 • 104 citations

A Bayesian Method for Synthesizing Evidence: The Confidence Profile Method

1990 • 103 citations

A Double-Blind Study of Tranylcypromine Treatment of Major Anergic Depression

1982 • 103 citations

Phenelzine and Amitriptyline: Effects on Symptoms of Neurotic Depression

1982 • 100 citations

Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study.

1980 • 91 citations

Characteristics of responders to fluoxetine.

1984 • 82 citations

An Efficacy Study of Isocarboxazid and Placebo in Depression, and Its Relationship to Depressive Nosology

1988 • 81 citations

Fluoxetine, a Selective Serotonin Uptake Inhibitor, for the Treatment of Outpatients with Major Depression

1988 • 80 citations

A double‐blind placebo‐controlled study of fluvoxamine and imipramine in out‐patients with primary depression.

1983 • 80 citations

A fixed-dose (300 mg) efficacy study of bupropion and placebo in depressed outpatients.

1990 • 72 citations

Excretion of 3-methoxy-4-hydroxymandelic acid (VMA) in depressed patients treated with antidepressant drugs

1964 • 66 citations

Fluvoxamine in the Treatment of the Older Depressed Patient; Double-blind, Placebo-controlled Data

1986 • 65 citations

A double-blind placebo-controlled study of fluvoxamine and imipramine in depression.

1985 • 64 citations

Paroxetine in the treatment of depression: a comparison with imipramine and placebo

1989 • 60 citations

Depression in Primary Care: Detection, Diagnosis, and Treatment

1994 • 60 citations

Pattern analysis shows beneficial effect of fluoxetine treatment in mild depression.

1990 • 58 citations

Treatment of major affective disorder with fluvoxamine.

1987 • 58 citations

Psychopharmacologic validation of atypical depression.

1984 • 54 citations

Placebo response rates in psychotic and nonpsychotic depression

1988 • 54 citations

A Controlled Trial of Phenelzine (“Nardil”) in the Treatment of Severe Depressive Illness

1961 • 52 citations

PREVIOUS MEDICATION, DURATION OF ILLNESS AND PLACEBO RESPONSE

1966 • 52 citations

Baseline characteristics of 10-day placebo washout responders in antidepressant trials

1987 • 50 citations

A fixed-dose clinical trial of fluoxetine in outpatients with major depression.

1987 • 48 citations

Fluvoxamine, imipramine, and placebo in the treatment of depressed outpatients: effects on depression.

1989 • 45 citations

The introductory placebo washout: A retrospective evaluation

1989 • 45 citations

A double-blind study of bupropion and placebo in depression

1984 • 44 citations

Imipramine for treatment of chronic depression.

1985 • 40 citations

Trazodone, a new antidepressant: efficacy and safety in endogenous depression.

1979 • 40 citations

Trazodone, a triazolopyridine derivative, in primary depressive disorder.

1980 • 38 citations

Comparison of alprazolam, imipramine, and placebo in the treatment of depression

1983 • 37 citations

Prediction of response of chronic depression to imipramine

1989 • 35 citations

The Dexamethasone Suppression Test and Response to Placebo

1986 • 35 citations

Trazodone in the treatment of neurotic depression.

1980 • 28 citations

An Evaluation of Alprazolam in the Treatment of Reactive or Neurotic (Secondary) Depression

1985 • 28 citations

A double-blind comparative evaluation of the efficacy and safety of nomifensine, imipramine, and placebo in depressed geriatric outpatients.

1984 • 27 citations

A Controlled Study of Trazodone, Imipramine, and Placebo in Outpatients with Endogenous Depression

1981 • 26 citations

Amoxapine and imipramine in the treatment of depressed outpatients: a controlled study

1981 • 26 citations

Pretreatment orthostatic hypotension in geriatric depression: predictor of response to imipramine and doxepin.

1983 • 25 citations

The use of bupropion in hospitalized depressed patients.

1983 • 25 citations

Comparative efficacy of alprazolam, imipramine, and placebo administered once a day in treating depressed patients.

1986 • 25 citations

Pattern analysis of antidepressant response to fluoxetine.

1986 • 20 citations

A Double-Blind Comparative Trial of Zimelidine, Amitriptyline, and Placebo in Patients with Mixed Anxiety and Depression

1986 • 18 citations

Placebo‐controlled trial of mianserin and maprotiline in primary depressive illness: a preliminary report.

1983 • 16 citations

Phenelzine versus imipramine in atypical depression

1985 • 16 citations

Nomifensine, Imipramine and Placebo in Depressed Outpatients

1982 • 15 citations

AN EVALUATION OF TRANYLCYPROMINE (“PARNATE”) IN THE TREATMENT OF DEPRESSION

1962 • 14 citations

Cianopramine and amitriptyline in the treatment of depressed patients ? a placebo-controlled study

1985 • 14 citations

Maprotiline versus imipramine and placebo in neurotic depression.

1981 • 13 citations

Experimental comparison between the effect of standardized trazodone-amitriptyline and placebo treatment in vitalized depressive patients

1988 • 12 citations

Assessing treatment response to the monoamine oxidase inhibitor isocarboxazid.

1984 • 10 citations

A double‐blind, controlled evaluation of zimeldine, imipramine and placebo in patients with primary affective disorders

1983 • 9 citations

A comparative investigation of isocarboxazid and imipramine in depressive syndromes. A second report.

1962 • 8 citations

A CRITICAL STUDY OF ISOCARBOXAZID (MARPLAN) IN THE TREATMENT OF DEPRESSED PATIENTS

1967 • 8 citations

Initial response to drugs in depressive illness and psychiatric and community adjustment a year later

1978 • 7 citations

Phenelzine and imipramine in mood reactive depressives. Further delineation of the syndrome of atypical depression

1990 • 7 citations

Efficacy of desipramine in mildly depressed patients: a double-blind, placebo-controlled trial [proceedings].

1981 • 6 citations

Trazodone in depressed outpatients

1982 • 2 citations