Determination of Single-Nucleotide Polymorphisms by Real-time Pyrophosphate DNA Sequencing

Molecular Beacons: Probes that Fluoresce upon Hybridization

1996 • 4,073 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

1995 • 1,619 citations

A Sequencing Method Based on Real-Time Pyrophosphate

1998 • 1,593 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Light-generated oligonucleotide arrays for rapid DNA sequence analysis.

1994 • 1,353 citations

Real-Time DNA Sequencing Using Detection of Pyrophosphate Release

1996 • 1,157 citations

Variations on a Theme: Cataloging Human DNA Sequence Variation

1997 • 1,064 citations

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

1999 • 1,023 citations

A Ligase-Mediated Gene Detection Technique

1988 • 834 citations

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.

1988 • 741 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

Angiotensin Receptors and Their Antagonists

1996 • 568 citations

Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene

1991 • 435 citations

A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E

1990 • 402 citations

Zur Kenntnis der antifermentativen, lytischen und agglutinierenden Wirkungen des Blutserums und der Lymphe

1900 • 389 citations

From gels to chips: ?Minisequencing? primer extension for analysis of point mutations and single nucleotide polymorphisms

1999 • 335 citations

An estimate of unique DNA sequence heterozygosity in the human genome

1985 • 297 citations

Detection of mutations by cleavage of DNA heteroduplexes with bacteriophage resolvases

1995 • 249 citations

Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis.

1996 • 219 citations

DNA variation and the future of human genetics

1998 • 217 citations

Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing.

1993 • 202 citations

DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale

1996 • 202 citations

Single nucleotide polymorphic discrimination by an electronic dot blot assay on semiconductor microchips

1999 • 198 citations

Enzymatic method for continuous monitoring of inorganic pyrophosphate synthesis

1985 • 187 citations

Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter.

1990 • 132 citations

Genetic testing: The problems and the promise

1997 • 103 citations

Mass spectrometry from miniaturized arrays for full comparative DNA analysis

1997 • 93 citations

The Genomic Organization of Human Angiotensin II Type 1 Receptor

1994 • 77 citations

[29] Polymerase chain reaction amplification of specific alleles: A general method of detection of mutations, polymorphisms, and haplotypes

1993 • 74 citations

Solid phase DNA sequencing using the biotin-avidin system

1988 • 66 citations

Rapid genotyping of human platelet antigen 1 (HPA‐1) with fluorophore‐labelled hybridization probes on the LightCycler^TM

1999 • 43 citations

Manifold sequencing: efficient processing of large sets of sequencing reactions.

1994 • 36 citations

Advances in DNA diagnostics

1998 • 28 citations

Familial t(11;13)(q21;q14) and the duplication 11q, 13q phenotype

1993 • 22 citations

Mining the Swedish clinical archives to develop pharmacogenomic tests

1999 • 4 citations

Characterization of polymorphisms IVS25AS-6A to G, C1237T and T3409C in the human angiotensin converting enzyme gene

1998 • 1 citations