Improved Islet Yields From Macaca Nemestrina and Marginal Human Pancreata After Two‐Layer Method Preservation and Endogenous Trypsin Inhibition

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

A spectrophotometric determination of trypsin and chymotrypsin

1955 • 1,551 citations

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

2001 • 864 citations

Islet isolation assessment in man and large animals

1990 • 575 citations

BRAIN DEATH AND ITS INFLUENCE ON DONOR ORGAN QUALITY AND OUTCOME AFTER TRANSPLANTATION1

1999 • 318 citations

VARIABLES IN ORGAN DONORS THAT AFFECT THE RECOVERY OF HUMAN ISLETS OF LANGERHANS1

1996 • 306 citations

Improved Human Islet Isolation Using a New Enzyme Blend, Liberase

1997 • 303 citations

Intraductal Collagenase Delivery into the Human Pancreas Using Syringe Loading or Controlled Perfusion

1999 • 204 citations

ACTIVATION OF INFLAMMATORY MEDIATORS IN RAT RENAL ISOGRAFTS BY DONOR BRAIN DEATH1

2000 • 186 citations

Rapid assessment of islet viability with acridine orange and propidium iodide

1988 • 161 citations

A NEW, SIMPLE METHOD FOR COLD STORAGE OF THE PANCREAS USING PERFLUOROCHEMICAL

1988 • 147 citations

HUMAN ISLET ISOLATION IN 104 CONSECUTIVE CASES

1994 • 130 citations

Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

1996 • 106 citations

HUMAN PANCREAS PRESERVATION PRIOR TO ISLET ISOLATION

1995 • 99 citations

Heme Oxygenase-1 Protects Pancreatic β Cells from Apoptosis Caused by Various Stimuli

2001 • 92 citations

Peroxynitrite Is a Mediator of Cytokine-Induced Destruction of Human Pancreatic Islet β Cells

2001 • 82 citations

SERINE-PROTEASE INHIBITION DURING ISLET ISOLATION INCREASES ISLET YIELD FROM HUMAN PANCREASES WITH PROLONGED ISCHEMIA1

2001 • 75 citations

Insulin Secretion, DNA Damage, and Apoptosis in Human and Rat Islets of Langerhans Following Exposure to Nitric Oxide, Peroxynitrite, and Cytokines

1998 • 75 citations

Excellence of the two-layer method (University of Wisconsin solution/perfluorochemical) in pancreas preservation before islet isolation

1997 • 69 citations

The Use of Fluorescein Diacetate and Ethidium Bromide as a Viability Stain for Isolated Islets of Langerhans

1987 • 64 citations

DIRECT EVIDENCE OF PANCREATIC TISSUE OXYGENATION DURING PRESERVATION BY THE TWO-LAYER METHOD

1996 • 62 citations

Pancreatic secretory trypsin inhibitor as a marker for early detection of rejection in canine pancreas allotransplantation.

1989 • 62 citations

Insulin down-regulates the inducible nitric oxide synthase pathway: nitric oxide as cause and effect of diabetes?

1997 • 57 citations

NITRIC OXIDE MEDIATES EARLY DYSFUNCTION OF RAT AND MOUSE ISLETS AFTER TRANSPLANTATION1

1996 • 57 citations

Dynamic Perifusion to Maintain and Assess Isolated Pancreatic Islets

2002 • 56 citations

Improved method for the isolation and purification of human islets of Langerhans using Liberase™ enzyme blend

1999 • 54 citations

Establishment of Fluorescein Diacetate and Ethidium Bromide (FDAEB) Assay for Quality Assessment of Isolated Islets

2000 • 49 citations

Human Pancreas Preservation Prior to Islet Isolation

2002 • 41 citations

Isolation of porcine pancreatic islets: Low trypsin activity during the isolation procedure guarantees reproducible high islet yields

1994 • 40 citations

THE EFFECT OF OUABAIN (INHIBITOR OF AN ATP-DEPENDENT NA+/K+ PUMP) ON THE PANCREAS GRAFT DURING PRESERVATION BY THE TWO-LAYER METHOD1

1996 • 39 citations

Analysis of United States (US) and non-US pancreas transplants as reported to the International Pancreas Transplant Registry (IPTR) and to the United Network for Organ Sharing (UNOS).

1998 • 37 citations

Restoration of pancreas graft function preserved by a two-layer (University of Wisconsin solution/perfluorochemical) cold storage method after significant warm ischemia.

1993 • 36 citations

Report for the International Pancreas Transplant Registry—2000

2001 • 35 citations

CORRELATION BETWEEN HIGH ADENOSINE TRIPHOSPHATE TISSUE CONCENTRATION AND GOOD POSTTRANSPLANT OUTCOME FOR THE CANINE PANCREAS GRAFT AFTER PRESERVATION BY THE TWO-LAYER COLD STORAGE METHOD

1991 • 35 citations

A microfluorometric viability assay for isolated human and rat islets of Langerhans.

1989 • 35 citations

Regulation of glutamic acid decarboxylase diabetes autoantigen expression in highly purified isolated islets from Macaca nemestrina.

1993 • 33 citations

Islet Cell Transplantation: In Vivo and in Vitro Functional Assessment of Nonhuman Primate Pancreatic Islets

2000 • 32 citations

RESTORATION OP PANCREAS GRAFT FUNCTION PRESERVED BY A TWO-LAYER (UNIVERSITY OF WISCONSIN SOLUTION/PERFLUOROCHEMICAL) COLD STORAGE METHOD AFTER SIGNIFICANT WARM ISCHEMIA

1993 • 31 citations

IMMEDIATE REVERSAL OF DIABETES IN PRIMATES FOLLOWING INTRAPORTAL TRANSPLANTATION OF PORCINE ISLETS PURIFIED ON A NEW HISTIDINE-LACTOBIONATE-IODIXANOL GRADIENT

1999 • 30 citations

The use of continuous density gradients for the assessment of islet and exocrine tissue densities and islet purification

1993 • 28 citations

A COMPARISON OF FOUR SOLUTIONS FOR COLD STORAGE OF PANCREATIC ISLETS1

1993 • 26 citations

Improved outcome of pig islet isolation by pefabloc inhibition of trypsin

1997 • 26 citations

RESUSCITATION OF ISCHEMICALLY DAMAGED PANCREAS DURING SHORT-TERM PRESERVATION AT 20??C BY THE TWO-LAYER (UNIVERSITY OF WISCONSIN SOLUTION/PERFLUOROCHEMICAL) METHOD

1996 • 20 citations

Evidence of Protein Synthesis During Resuscitation of Ischemically Damaged Canine Pancreas by the Two-Layer Method

2000 • 18 citations

Cell signaling and heat shock protein expression

1996 • 18 citations

The effect of the two-layer cold storage method on islet isolation from ischemically damaged pancreas.

1999 • 17 citations

Effect of Prophylactic Administration of Trypsin Inhibitors in Porcine Pancreas Islet Isolation

1998 • 16 citations

Article Commentary: Islet Transplantation

1999 • 16 citations

Airway Goblet Cells and Respiratory Epithelial Injury in an Animal Model of Obliterative Airways Disease (OAD)

2001 • 13 citations

University of wisconsin solution with trypsin inhibitor pefabloc improves survival of viable human and primate impure islets during storage.

2001 • 12 citations

Lessons from in Vitro Perifusion of Pancreatic Islets Isolated from 80 Human Pancreases

1999 • 12 citations

PROLONGED PRESERVATION OF THE HUMAN PANCREAS PRIOR TO ISLET ISOLATION USING THE TWO-LAYER (UNIVERSITY OF WISCONSIN SOLUTION [UW]/ PERFLUOROCARBON) METHOD.

2000 • 9 citations

Is Islet Transplantation a Realistic Therapy for the Treatment of Type 1 Diabetes in the Near Future?

2001 • 5 citations

Re-evaluation of donor factors affecting islet isolation from human pancreas using a two-step digestion method

1997 • 4 citations