Reduced Density of Cholinergic Interneurons in the Ventral Striatum in Schizophrenia: An In Situ Hybridization Study

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

2004 • 1,637 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones

1990 • 1,021 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Discordant Protein and mRNA Expression in Lung Adenocarcinomas

2002 • 913 citations

Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells

2004 • 753 citations

Increased dopamine transmission in schizophrenia: relationship to illness phases

1999 • 713 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

1983 • 546 citations

Gating of information flow within the limbic system and the pathophysiology of schizophrenia

2000 • 522 citations

Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

1994 • 469 citations

Glutamate, Dopamine, and Schizophrenia

2003 • 435 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins

1995 • 349 citations

Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia

2000 • 340 citations

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.

1994 • 304 citations

INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES

1977 • 254 citations

The Concept of the Ventral Striatum in Nonhuman Primates

1999 • 243 citations

Comparative distribution of mRNAs for glutamic acid decatrboxylase, tyrosine hydroxylase, and tachykinins in the basal ganglia: An in situ hybridization study in the rodent brain

1987 • 232 citations

In Vivo Determination of Muscarinic Acetylcholine Receptor Availability in Schizophrenia

2002 • 204 citations

INCREASED DOPAMINE CONCENTRATION IN LIMBIC AREAS OF BRAIN FROM PATIENTS DYING WITH SCHIZOPHRENIA

1979 • 203 citations

Antipsychotic drugs and neuroplasticity: insights into the treatment and neurobiology of schizophrenia

2001 • 195 citations

Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists

2004 • 180 citations

Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease and in relation to neuroleptic medication

2000 • 155 citations

Sequence of the Human Somatostatin I Gene

1984 • 154 citations

In situ hybridization histochemistry with synthetic oligonucleotides: Strategies and methods

1985 • 153 citations

Adverse effects of anticholinergic medication on positive schizophrenic symptoms

1983 • 152 citations

The density of muscarinic M1 receptors is decreased in the caudate-putamen of subjects with schizophrenia.

1996 • 145 citations

Xanomeline and the Antipsychotic Potential of Muscarinic Receptor Subtype Selective Agonists

2003 • 139 citations

THE PRESENT STATUS OF PSYCHOTROPIC DRUGS

1966 • 137 citations

Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia

1999 • 135 citations

Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia

1993 • 134 citations

Human post-mortem striatal α4β2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome

2000 • 111 citations

Neuronal types in the striatum of man

1982 • 103 citations

Various Enzymes Involved With Putative Neurotransmitters

1973 • 89 citations

Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities

1987 • 84 citations

Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression.

1994 • 83 citations

Differential Effects of Haloperidol, Risperidone, and Clozapine Exposure on Cholinergic Markers and Spatial Learning Performance in Rats

2002 • 83 citations

Haloperidol alters rat CNS cholinergic system: Enzymatic and morphological analyses

1988 • 77 citations

Possible Changes in Striatal and Limbic Cholinergic Systems in Schizophrenia

1977 • 70 citations

Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease

2003 • 56 citations

Effect of anticholinergic medication on positive and negative symptoms in medication-free schizophrenic patients

1990 • 54 citations

Anticholinergic-neuroleptic antagonism in terms of positive and negative symptoms of schizophrenia: implications for psychobiological subtyping

1987 • 53 citations

Muscarinic1 and 2 receptor mRNA in the human caudate-putamen: no change in m1 mRNA in schizophrenia

2000 • 53 citations

Pathochemical Markers in Major Psychoses

1985 • 48 citations

CHOLINERGIC INNERVATION IN THE HUMAN STRIATUM: A THREE-COMPARTMENT MODEL

1996 • 48 citations

Morphological Backgrounds of Pathochemical Studies in Major Psychoses

1985 • 41 citations

cAMP-Dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD)

2003 • 35 citations

Chronic fluphenazine and clozapine elicit opposite changes in brain muscarinic receptor binding: implications for understanding tardive dyskinesia.

1983 • 33 citations

Decreased choline acetyltransferase immunoreactivity in discrete striatal subregions following chronic haloperidol in rats

2000 • 29 citations

Human choline acetyltransferase (CHAT): Partial gene sequence and potential control regions

1992 • 26 citations

Differential Alterations in Striatal Acetylcholine Function in Rats During 12 Monthsʼ Continuous Administration of Haloperidol, Sulpiride, or Clozapine

1986 • 24 citations

Choline High‐Affinity Uptake and Metabolism and Choline Acetyltransferase Activity in the Striatum of Rats Chronically Treated with Neuroleptics

1980 • 24 citations

The use of LSD and ditran in the treatment of therapy resistant schizophrenics (symptom provocation approach).

1969 • 17 citations

Neuroleptic-induced striatal damage in rats: a study of antioxidant treatment using accelerometric and immunocytochemical methods

2000 • 12 citations

Monosialoganglioside cotreatment prevents haloperidol treatment—associated loss of cholinergic enzymes in rat brain

1995 • 9 citations

Neonatal 6-OHDA lesions upregulate adult expression of tyrosine hydroxylase mRNA.

1993 • 7 citations

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