Role of phosphoinositide metabolism in functional antagonism of airway smooth muscle contraction by β-adrenoceptor agonists

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Contractile responses of the guinea-pig trachea in vitro: modification by prostaglandin synthesis-inhibiting drugs.

1975 • 220 citations

In Vitro Studies of Antigen-Induced Bronchospasm: Effect of Antihistamine and SRS-A Antagonist on Response of Sensitized Guinea Pig and Human Airways to Antigen

1979 • 192 citations

Muscarinic cholinergic inhibition of adenylate cyclase in airway smooth muscle

1987 • 136 citations

β ‐Adrenoceptor stimulation inhibits histamine‐stimulated inositol phospholipid hydrolysis in bovine tracheal smooth muscle

1988 • 121 citations

Dose‐response curves to inhaled beta‐adrenoceptor agonists in normal and asthmatic subjects.

1983 • 117 citations

Carbachol induces a rapid and sustained hydrolysis of polyphosphoinositide in bovine tracheal smooth muscle measurements of the mass of polyphosphoinositides, 1,2-diacylglycerol, and phosphatidic acid.

1986 • 116 citations

The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells.

1985 • 92 citations

I. Development and first check of a new model of functional synergism and antagonism

1973 • 83 citations

Functional antagonism in canine tracheal smooth muscle: inhibition by methacholine of the mechanical and biochemical responses to isoproterenol.

1983 • 73 citations

Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists

1988 • 67 citations

Inhibitory effect of methacholine on drug-induced relaxation, cyclic AMP accumulation, and cyclic AMP-dependent protein kinase activation in canine tracheal smooth muscle.

1985 • 62 citations

A study of the histamine H₂‐receptor mediating relaxation of the parenchymal lung strip preparation of the guinea‐pig

1985 • 58 citations

Response and sensitivity of isolated human pulmonary muscle preparations to pharmacological agents.

1985 • 57 citations

Differential inhibitory effect of isoproterenol on contractions of canine airways

1984 • 41 citations

Regulation of the beta-receptor-adenylate cyolase system in lymphocytes of allergic patients with asthma: Possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase

1987 • 40 citations

Endogenous prostaglandins modulate histamine-induced contraction in canine tracheal smooth muscle

1985 • 36 citations

The role of the parasympathetic nervous system in the maintenance of chronic airway obstruction in asthmatic children.

1975 • 35 citations

Stimulation of phosphatidylinositol metabolism in atrial and ventricular myocytes

1986 • 34 citations

Differential relaxant effects of isoproterenol on methacholine- versus leukotriene D4-induced contraction in the guinea-pig trachea

1984 • 29 citations

Phorbol 12-myristate 13-acetate induces beta-adrenergic receptor uncoupling and non-specific desensitization of adenylate cyclase in human mononuclear leukocytes

1986 • 28 citations

Phorbol myristate acetate causes in guinea‐pig lung parenchymal strip a maintained spasm which is relatively resistant to isoprenaline

1985 • 27 citations

In vivo functional antagonism between isoproterenol and bronchoconstrictants in the dog

1987 • 26 citations

A study of the H₂‐receptor for histamine stimulating adenylate cyclase in homogenates of guinea‐pig lung parenchyma

1986 • 16 citations