Opioid peptide levels in gerbil brain after transient ischemia: lasting depletion of hippocampal dynorphin.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

New Tables for Multiple Comparisons with a Control

1964 • 3,084 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

A new model of bilateral hemispheric ischemia in the unanesthetized rat.

1979 • 1,934 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies

1983 • 554 citations

Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.

1977 • 451 citations

Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

1981 • 357 citations

The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

1983 • 356 citations

Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus)

1966 • 314 citations

Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity.

1983 • 289 citations

Determination of methionine enkephalin in discrete regions of rat brain

1977 • 280 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia

1980 • 231 citations

THE EFFECT OF ISCHAEMIA AND RECIRCULATION ON PROTEIN SYNTHESIS IN THE RAT BRAIN

1977 • 220 citations

Endorphins in experimental spinal injury: Therapeutic effect of naloxone

1981 • 214 citations

NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN

1981 • 208 citations

Reversal of Induced Ischemic Neurologic Deficit in Gerbils by the Opiate Antagonist Naloxone

1982 • 205 citations

Protein synthesis in the cat brain after prolonged cerebral ischemia

1971 • 184 citations

A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation

1985 • 179 citations

Changes in Brain Energy Metabolism and Protein Synthesis Following Transient Bilateral Ischemia in the Gerbil

1985 • 174 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology

1983 • 170 citations

Induction of Brain Ornithine Decarboxylase During Recovery from Metabolic, Mechanical, Thermal, or Chemical Injury

1984 • 153 citations

A specific radioimmunoassay for the novel opioid peptide dynorphin

1980 • 141 citations

Dynorphin-related immunoreactive peptides in rat brain and pituitary

1980 • 138 citations

The role of brain edema in epileptic brain damage induced by systemic kainic acid injection

1984 • 134 citations

Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary

1983 • 133 citations

Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus

1985 • 131 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells

1986 • 127 citations

Selective Gene Expression in Focal Cerebral Ischemia

1986 • 123 citations

The distribution and morphology of opioid peptide immunoreactive neurons in the cerebral cortex of rats

1984 • 120 citations

Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury

1985 • 107 citations

Temporal Profiles of Proteins Responsive to Transient Ischemia

1985 • 103 citations

α-Adrenergic Stimulation by Clonidine Increases Plasma Concentrations of Immunoreactive β-Endorphin in Rats

1981 • 88 citations

Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agent

1985 • 88 citations

Naloxone or TRH fails to improve neurologic deficits in gerbil models of “stroke”

1982 • 83 citations

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic-basal ganglia regions of rat brain after repeated electroconvulsive shock.

1986 • 82 citations

Dynorphin- and enkephalin-like immunoreactivity is altered in limbic- basal ganglia regions of rat brain after repeated electroconvulsive shock

1986 • 75 citations

A double blind trial of naloxone in the treatment of acute stroke.

1984 • 71 citations

Regional Distribution of Methionine‐Enkephalin‐Arg⁶‐Phe⁷ in the Rat Brain: Comparative Study with the Distribution of Other Opioid Peptides

1983 • 68 citations

Naloxone therapy during focal cerebral ischemia evaluation in a primate model.

1984 • 66 citations

Naloxone administration to patients with acute stroke.

1984 • 66 citations

Dynorphin(1–13) improves survival in cats with focal cerebral ischaemia

1984 • 61 citations

Cerebral ischemia in gerbils: polyribosomal function during progression and recovery.

1981 • 53 citations

Effect of naloxone on neurologic deficit and cortical blood flow during focal cerebral ischemia in cats

1982 • 51 citations

Contrast medium causes the apparent increase in β-endorphin levels in human cerebrospinal fluid following brain stimulation

1984 • 51 citations

Opiate antagonist WIN44, 441–3 stereospecifically improves neurologic recovery after ischemic spinal injury

1985 • 50 citations

Selective vulnerability of brain: New insights from the excitatory synapse

1986 • 50 citations

Naloxone reversal of ischemic neurologic deficits in baboons is not mediated by systemic effects

1982 • 49 citations

Failure of naloxone to reverse Vascular neurologic deficits

1983 • 47 citations

Changes in hippocampal immunoreactive dynorphin and -neoendorphin content following intra-amygdalar kainic acid-induced seizures

1983 • 45 citations

Immunoreactive Somatostatin and β-Endorphin Content in the Brain of Mature Rats after Neonatal Exposure to Propylthiouracil*

1982 • 44 citations

Effects of traumatic injury on dynorphin immunoreactivity in spinal cord

1985 • 42 citations

Treatment of experimental stroke with opiate antagonists

1986 • 36 citations

Repeated electroconvulsive shocks alter the biosynthesis of enkephalin and concentration of dynorphin in the rat brain

1985 • 32 citations

Adrenergic control of immunoreactive beta-endorphin release from the pituitary of the rat: in vitro and in vivo studies.

1982 • 31 citations

Failure of MIF-1 or naloxone to reverse ischemic-induced neurologic deficits in gerbils

1982 • 29 citations

Naloxone ameliorates the pathophysiologic changes which lead to and attend an acute stroke in stroke-prone/SHR.

1984 • 28 citations

Multiple Molecular Forms of Enkephalins in the Guinea Pig Hippocampus

1983 • 18 citations

Diagnosis of reversible versus irreversible cerebral ischemia by the intravenous administration of naloxone.

1985 • 14 citations

Naloxone and Ischemic Neurologic Deficits in the Gerbil: Is There an Effect?

1982 • 6 citations