Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 • 528 citations

Effect of age and gender on the activity of human hepatic CYP3A

1992 • 425 citations

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1982 • 422 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1994 • 350 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

1988 • 237 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

Drug metabolism in human liver in vitro: Establishment of a human liver bank

1980 • 176 citations

“It's the genes, stupid” Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1995 • 162 citations

Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver

1995 • 141 citations

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

1989 • 117 citations

In vitro forecasting of drugs which may interfere with the biotransformation of midazolam

1991 • 107 citations

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

1986 • 70 citations

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation

1987 • 63 citations

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies

1996 • 51 citations

Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents

1983 • 30 citations