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Effects of ascorbic acid on the nonenzymatic binding to DNA and the mutagenicity of N-hydroxylated metabolite of a tryptophan-pyrolysis product

Data up to Jan 2025

Published1982
Citations19
References11

Total Citations Per Year

Abstract

References (11)

Chemical Carcinogenesis

1975 • 741 citations

Ascorbic acid and cancer: a review.

1979 • 425 citations

Mechanism of in vitro mutagenic activation and covalent binding of N-hydroxy-2-acetylaminofluorene in isolated liver cell nuclei from rat and mouse.

1978 • 81 citations

Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, TRP-P-2, formed by rat liver microsomes

1980 • 75 citations

Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole. Identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reaction with DNA

1980 • 68 citations

Mechanism of N-hydroxyacetylarylamine mutagenicity in the Salmonella test system: metabolic activation of N-hydroxyphenacetin by liver and kidney fractions from rat, mouse, hamster, and man.

1980 • 63 citations

Mechanism of N-hydroxy-2-acetylaminofluorene mutagenicity in the Salmonella test system. Role of N-O acyltransferase and sulfotransferase from rat liver.

1981 • 41 citations

Evidence for the involvement of N-hydroxylation of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by cytochrome P-450 in the covalent binding to DNA.

1981 • 39 citations

Studies on the mutagenicity of N-hydroxy-2-acetylaminofluorene in the ames-salmonella mutagenesis test system

1978 • 32 citations

Effect of ascorbic acid on in vitro mutagenicity and in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in the rat

1980 • 22 citations

Ascorbic acid inhibits covalent binding of enzymatically generated 2-acetyl-aminofluorene-N-sulfate to DNA under conditions in which it increases mutagenesis in salmonella TA-1538

1979 • 17 citations

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