Biosynthesis and chemical synthesis of carboxyl-linked glucuronide of lithocholic acid

Glucuronidation of Drugs and Other Compounds

2019 • 807 citations

Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometry

1977 • 489 citations

The Bile Acids: Chemistry, Physiology, and Metabolism

1988 • 299 citations

Properties of Acyl Glucuronides: Implications for Studies of the Pharmacokinetics and Metabolism of Acidic Drugs

1984 • 299 citations

Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium

1980 • 135 citations

Advances in glucuronide conjugation

1985 • 130 citations

Hydroxylation of cholic, chenodeoxycholic, and deoxycholic acids in patients with intrahepatic cholestasis

1980 • 127 citations

Analysis of bile acid glucuronides in urine. Identification of 3α,6α,12α-trihydroxy-5β-cholanoic acid

1980 • 125 citations

The fate of bilirubin-IXα glucuronide in cholestasis and during storage in vitro. Intramolecular rearrangement to positional isomers of glucuronic acid

1978 • 123 citations

Retinoyl β-glucuronide: an endogenous compound of human blood

1986 • 101 citations

Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes.

1987 • 91 citations

Glucuronic acid conjugates of bilirubin-IXα in normal bile compared with post-obstructive bile. Transformation of the 1-O-acylglucuronide into 2-, 3-, and 4-O-acylglucuronides

1978 • 88 citations

Glucuronides of monohydroxylated bile acids: specificity of microsomal glucuronyltransferase for the glucuronidation site, C-3 configuration, and side chain length.

1986 • 82 citations

Lithocholate glucuronide is a cholestatic agent.

1984 • 79 citations

Mass spectrometry of steroids

1976 • 68 citations

Studies of intramolecular rearrangements of acyl-linked glucuronides using salicyclic acid, flufenamic acid, and (S)- and (R)-benoxaprofrn and confirmation of isomerization in acyl-linked .DELTA.9-11-carboxytetrahydrocannabinol glucuronide

1989 • 67 citations

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia.

1989 • 63 citations

Mass spectrometry of steroids

1977 • 60 citations

Glucuronides of unconjugated 6-hydroxylated bile acids in urine of a patient with malabsorption

1978 • 55 citations

Glucuronic Esters—III

1965 • 52 citations

Origin of some derivatives of retinoic acid found in rat bile

1968 • 46 citations

Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes.

1989 • 39 citations

The chemical synthesis of 1-O-(indol-3′-ylacetyl)-β-<scp>d</scp>-glucopyranose. The higher activity of the glucoside in comparison with exogenous indol-3-ylacetic acid in plant-section elongation tests

1969 • 37 citations

Thin-layer and column chromatography of erythoromycins andsome degradation products

1968 • 31 citations

Preparation and characterization of 3-monohydroxylated bile acids of different side chain length and configuration at C-3. Novel approach to the synthesis of 24-norlithocholic acid.

1986 • 28 citations

Metabolism of 24-norlithocholic acid in the rat: Formation of hydroxyl- and carboxyl-linked glucuronides and effect on bile flow

1986 • 26 citations

Formation of three types of glucuronides of 6-hydroxy bile acids by rat liver microsomes.

1988 • 26 citations

Constituents of human meconium: II. Identification of steroidal acids with 21 and 22 carbon atoms

1982 • 25 citations

Biosynthesis of hydroxyl-linked glucuronides of short-chain bile acids by rat liver 3-hydroxysteroid UDP-glucuronosyltransferase.

1988 • 24 citations

A new protected form of glucuronic acid for the synthesis of labile 1-O-acyl-β-D-glucuronides

1989 • 24 citations

Constituents of human meconium—I. Identification of 3-hydroxy-etianic acids

1983 • 21 citations

A chemical synthesis of I-O-indomethacin-β-D-glucosyluronic acid

1971 • 19 citations

Impaired biliary elimination of beta-glucuronidase-resistant "glucuronides" of valproic acid after intravenous administration in the rat. Evidence for oxidative metabolism of the resistant isomers.

1986 • 18 citations

Importance of axial ligand in meso-tetraphenylporphinatoiron(III) promoted NO and OO bonds cleavages

1986 • 17 citations

Detection of 3-hydroxy-etianic and 3-hydroxy-bisnorcholanoic acids in human serum.

1984 • 16 citations

The identification of bile acid methyl esters by gas chromatography methane chemical ionization mass spectrometry

1979 • 14 citations

Characterization of acyl-linked glucuronides by electron impact and fast atom bombardment mass spectrometry

1988 • 13 citations

Synthesis and metabolism of all-trans-[11-3H]retinyl β-glucuronide in rats in vivo

1988 • 12 citations

Glucuronidation of monohydroxylated short chain bile acids by human liver microsomes and purified human liver UDP-glucuronosyltransferases.

1991 • 11 citations

Synthesis of biliverdin and bilirubin 1-O-acyl-β-<scp>d</scp>-glucopyranuronic acids

1980 • 11 citations

The synthesis and characterization of the glucopyranosiduronic acids of 17α-ethynylestradiol-17β

1980 • 7 citations

Constituents of human meconium—III. Identification of 3,20-dihydroxypregnan-21-oic acids

1987 • 5 citations