The two faces of IL-6 on Th1/Th2 differentiation

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Interleukin-18 Regulates Both Th1 and Th2 Responses

2001 • 1,284 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

1997 • 823 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

1998 • 661 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

2000 • 397 citations

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

1992 • 327 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

Requirement for Transcription Factor NFAT in Interleukin-2 Expression

1999 • 196 citations

Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation

2002 • 196 citations

The two C/EBP isoforms, IL6DBP/NFIL6 and CEBP6δ/NFIL63, are induced by IL6β to promote acute phase gene transcription via different mechanisms

1993 • 176 citations

Role of IL-4 and IFN-gamma in modulation of immunity to Borrelia burgdorferi in mice.

1995 • 170 citations

T helper phenotype and genetic susceptibility in experimental Lyme disease.

1995 • 157 citations

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor

1999 • 128 citations

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

1999 • 115 citations

Effect of anti-interleukin 12 treatment on murine lyme borreliosis.

1996 • 96 citations

Recombinant IL-6 activates p42 and p44 mitogen-activated protein kinases in the IL-6 responsive B cell line, AF-10.

1993 • 88 citations

Transcriptional control in the Th1/Th2 decision

1997 • 82 citations

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

1998 • 66 citations

T-Cell Subsets: Who does the polarizing?

1995 • 65 citations

Neutralization of interferon‐γ in neonatal SOCS1^−/− mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease

2001 • 44 citations

Signal Transduction through IL‐6 Receptor: Involvement of Multiple Protein Kinases, Stat Factors, and a Novel H7‐sensitive Pathwaya

1995 • 42 citations