The Location of the Active Site of Blood Coagulation Factor VIIa above the Membrane Surface and Its Reorientation upon Association with Tissue Factor

The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer

1979 • 744 citations

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1996 • 726 citations

Surface density determination in membranes by fluorescence energy transfer

1978 • 422 citations

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid.

1976 • 278 citations

Biochemical and Molecular Aspects of the Coagulation Cascade

1995 • 261 citations

Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function

1991 • 228 citations

Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.

1981 • 201 citations

Calculation on fluorescence resonance energy transfer on surfaces

1980 • 194 citations

Interaction of vitamin K dependent proteins with membranes

1978 • 193 citations

The contributions of Ca2+, phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII

1990 • 193 citations

The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex.

1987 • 170 citations

Structure of the Extracellular Domain of Human Tissue Factor: Location of the Factor VIIa Binding Site

1994 • 143 citations

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation.

1991 • 136 citations

Orientation factor in steady-state and time-resolved resonance energy transfer measurements

1992 • 129 citations

Mechanism of activation of bovine factor VII. Products of cleavage by factor Xa.

1976 • 129 citations

Phosphatidylethanolamine augments factor VIIa-tissue factor activity: enhancement of sensitivity to phosphatidylserine

1995 • 114 citations

Structural studies on the membrane-bound immunoglobulin E-receptor complex. 1. Characterization of large plasma membrane vesicles from rat basophilic leukemia cells and insertion of amphipathic fluorescent probes

1983 • 113 citations

Factor VII autoactivation proceeds via interaction of distinct protease-cofactor and zymogen-cofactor complexes. Implications of a two-dimensional enzyme kinetic mechanism.

1993 • 112 citations

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.

1992 • 111 citations

Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions

1991 • 109 citations

Structure of the prothrombin- and blood clotting factor X-membrane complexes

1977 • 108 citations

Purification of recombinant human tissue factor

1989 • 107 citations

The active site of factor IXa is located far above the membrane surface and its conformation is altered upon association with factor VIIIa. A fluorescence study.

1992 • 105 citations

The Crystal Structure of the Extracellular Domain of Human Tissue Factor Refined to 1.7 Å Resolution

1996 • 104 citations

Roles of the membrane-interactive regions of factor VIIa and tissue factor. The factor VIIa Gla domain is dispensable for binding to tissue factor but important for activation of factor X.

1994 • 97 citations

Binding of factor VIIIa and factor VIII to factor IXa on phospholipid vesicles.

1992 • 87 citations

Human factor VIIa and its complex with soluble tissue factor: evaluation of asymmetry and conformational dynamics by ultracentrifugation and fluorescence anisotropy decay methods

1993 • 73 citations

Effects of nucleotide- and aurodox-induced changes in elongation factor Tu conformation upon its interactions with aminoacyl transfer RNA. A fluorescence study

1990 • 70 citations

Active site selective labeling of serine proteases with spectroscopic probes using thioester peptide chloromethyl ketones: demonstration of thrombin labeling using N.alpha.[(acetylthio)acetyl]-D-Phe-Pro-Arg-Ch2Cl

1988 • 66 citations

Spatial relationships between specific sites on reconstituted chloroplast proton adenosine triphosphatase and the phospholipid vesicle surface

1983 • 64 citations

High Affinity Ca2+-binding Site in the Serine Protease Domain of Human Factor VIIa and Its Role in Tissue Factor Binding and Development of Catalytic Activity

1995 • 61 citations

Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: evidence for its role in factor VII - tissue factor interaction

1993 • 57 citations

The active site of membrane-bound meizothrombin. A fluorescence determination of its distance from the phospholipid surface and its conformational sensitivity to calcium and factor Va.

1990 • 50 citations

Importance of substrate composition, pH and other variables on tissue factor enhancement of factor VIIa activity.

1993 • 49 citations

The Active Site of the Thrombin-Thrombomodulin Complex

1989 • 46 citations

Synthetic substrates for human factor VIIa and factor VIIa-tissue factor

1993 • 46 citations

Importance of Substrate Composition, pH and Other Variables on Tissue Factor Enhancement of Factor Vlla Activity

1993 • 43 citations

A method for on-line background subtraction in frequency domain fluorometry

1991 • 41 citations

A domain of membrane-bound blood coagulation factor Va is located far from the phospholipid surface. A fluorescence energy transfer measurement

1986 • 40 citations

Tissue factor potentiates the factor VIIa-catalyzed hydrolysis of an ester substrate.

1992 • 40 citations

Cooperative Interaction of Divalent Metal Ions, Substrate, and Tissue Factor with Factor VIIa

1994 • 37 citations

Structural mapping of Fc receptor bound immunoglobulin E: proximity to the membrane surface of the antibody combining site and another site in the Fab segments

1985 • 35 citations

Factor VIIa and the extracellular domains of human tissue factor form a compact complex: A study by X‐ray and neutron solution scattering

1995 • 17 citations

Effect of Soluble Tissue Factor on the Kinetic Mechanism of Factor VIIa: Enhancement of p-Guanidinobenzoate Substrate Hydrolysis

1996 • 13 citations