Polyunsaturated fatty acid deficit in patients with bipolar mania

A Rating Scale for Mania: Reliability, Validity and Sensitivity

1978 • 8,000 citations

Omega 3 Fatty Acids in Bipolar Disorder

1999 • 815 citations

Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants

1994 • 797 citations

Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.

1984 • 653 citations

Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder

2002 • 627 citations

Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study

1997 • 615 citations

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

1998 • 580 citations

Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients

1998 • 480 citations

Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression

1996 • 474 citations

Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

1999 • 446 citations

Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids

1996 • 426 citations

Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizers

1995 • 382 citations

α‐Linolenic Acid Dietary Deficiency Alters Age‐Related Changes of Dopaminergic and Serotoninergic Neurotransmission in the Rat Frontal Cortex

1996 • 336 citations

Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia

2001 • 330 citations

A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases

1994 • 250 citations

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis Possible candidate genes

1999 • 222 citations

Do Lithium and Anticonvulsants Target the Brain Arachidonic Acid Cascade in Bipolar Disorder?

2002 • 194 citations

Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group

2001 • 186 citations

Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients

1995 • 151 citations

Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers

2001 • 127 citations

Lipids, Membrane Receptors, and Enzymes: Effects of Dietary Fatty Acids

1990 • 122 citations

Function of dietary polyunsaturated fatty acids in the nervous system

1993 • 122 citations

In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress

2000 • 114 citations

Activation of indices of cell-mediated immunity in bipolar mania

1999 • 112 citations

Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects

1996 • 102 citations

Effects of symptomatic severity on elevation of plasma soluble interleukin-2 receptor in bipolar mania

2001 • 94 citations

Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro

2001 • 78 citations

Effect of lithium carbonate therapy on thyroid immune status in manic depressive patients: A prospective study

1986 • 65 citations

Mood Stabilizers: Shared Mechanisms of Action at Postsynaptic Signal-Transduction and Kindling Processes

1996 • 55 citations

Reduced production of interferon-gamma but not interleukin-10 in bipolar mania and subsequent remission

2002 • 47 citations

Schizophrenia, tardive dyskinesia and essential fatty acids

1996 • 43 citations

Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit

1990 • 37 citations

Immune function in mania

1988 • 34 citations

The effects of cigarette smoking on the metabolism of essential fatty acids

1999 • 31 citations

Fever and leukocytosis: Physical manifestations of bipolar affective disorder?

1988 • 12 citations

Clozapine: Elevation of membrane unsaturated lipid levels as a new mechanism of action

1997 • 2 citations