Antiepileptic Agents and Birth Defects

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

The fetal hydantoin syndrome

1975 • 602 citations

Spina Bifida in Infants of Women Treated with Carbamazepine during Pregnancy

1991 • 463 citations

Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome

1976 • 438 citations

MATERNAL EPILEPSY AND ABNORMALITIES OF THE FETUS AND NEWBORN

1972 • 412 citations

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

1981 • 389 citations

The fetal valproate syndrome

1984 • 387 citations

Multi‐institutional Study on the Teratogenicity and Fetal Toxicity of Antiepileptic Drugs: A Report of a Collaborative Study Group in Japan

1980 • 302 citations

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

1986 • 280 citations

Diphenylhydantoin and Selected Congenital Malformations

1973 • 242 citations

ANTICONVULSANTS AND PARENTAL EPILEPSY IN THE DEVELOPMENT OF BIRTH DEFECTS

1976 • 240 citations

Epilepsy and Pregnancy: A Report from the Oxford Record Linkage Study

1973 • 234 citations

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

1981 • 226 citations

GENETIC PREDISPOSITION TO PHENYTOIN-INDUCED BIRTH DEFECTS

1985 • 220 citations

Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

1969 • 218 citations

Anticonvulsant Drugs and Congenital Abnormalities

1968 • 218 citations

Teratogenicity of Antiepileptic Drug Combinations with Special Emphasis on Epoxidation (of Carbamazepine)

1984 • 214 citations

Teratogenicity of Antiepileptic Drugs: Analysis of Possible Risk Factors

1988 • 188 citations

The fetal trimethadione syndrome

1975 • 178 citations

Phenytoin teratogenesis: correlation between embryopathic effect and covalent binding of putative arene oxide metabolite in gestational tissue.

1977 • 166 citations

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

1981 • 166 citations

Diphenylhydantoin: Placental transport, fetallocalization, neonatal metabolism, and possible teratogenic effects

1971 • 164 citations

Maternal barbiturate utilization and neonatal withdrawal symptomatology

1972 • 156 citations

Teratogenic valproic acid concentrations: Infusion by implanted minipumps vs conventional injection regimen in the mouse

1985 • 156 citations

Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.

1992 • 155 citations

Advances in epileptology. XIII epilepsy international symposium

1983 • 155 citations

PHENYTOIN TERATOGENICITY IN MAN

1973 • 149 citations

The presence of a monooxygenase system in human fetal liver microsomes

1970 • 145 citations

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

1984 • 145 citations

Epilepsy, pregnancy, and the child

1982 • 140 citations

CONGENITAL MALFORMATIONS AMONG INFANTS BORN TO EPILEPTIC WOMEN

1973 • 138 citations

Anticonvulsants, folate levels, and pregnancy outcome: A prospective study

1987 • 138 citations

Anticonvulsant toxicity in vitro: possible role of arene oxides.

1981 • 137 citations

Minor anomalies in offspring of epileptic mothers

1988 • 131 citations

GROWTH RETARDATION, DYSMORPHIC FACIES AND MINOR MALFORMATIONS FOLLOWING MASSIVE EXPOSURE TO PHENOBARBITONE IN UTERO

1976 • 127 citations

Do Anticonvulsants Have a Teratogenic Effect?

1974 • 119 citations

Valproic acid in the perinatal period: Decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites

1984 • 111 citations

The Fetal Trimethadione Syndrome

1977 • 111 citations

Kainate-like neurotoxicity of folates

1981 • 108 citations

Congenital Malformations and Seizure Disorders in the Offspring of Parents with Epilepsy

1978 • 103 citations

Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome

1990 • 102 citations

ANTICONVULSANTS, FOLIC ACID, AND EPILEPSY

1973 • 101 citations

Sind antiepileptische Medikamente während der Schwangerschaft schädlich?

1964 • 100 citations

TERATOGENIC EFFECT OF ANTICONVULSANTS

1972 • 92 citations

Congenital Abnormalities and Anticonvulsant Drugs

1970 • 92 citations

Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: In vitro/in vivo correlation

1989 • 91 citations

PLACENTAL TRANSFER OF PHENOBARBITONE IN EPILEPTIC WOMEN, AND ELIMINATION IN NEWBORNS

1967 • 85 citations

Teratogenic effects of diphenylhydantoin sodium.

1966 • 84 citations

Epilepsy and pregnancy.

1993 • 80 citations

Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.

1983 • 80 citations

Malformation in infants of mothers with epilepsy receiving antiepileptic drugs.

1992 • 79 citations

Disposition of the antiepileptic oxcarbazepine and its metabolites in healthy volunteers

1982 • 78 citations

Teratogenic acitivity of the antiepileptic drugs phenobarbital, phenytoin, and primidone in mice

1975 • 71 citations

Associations Between Risk Factors for Valproate Hepatotoxicity and Altered Valproate Metabolism

1992 • 70 citations

Digital hypoplasia and anticonvulsants during gestation: A teratogenic syndrome?

1974 • 69 citations

Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and α-phenyl-N-t-butylnitrone: Implications for bioactivation by prostaglandin synthetase

1989 • 69 citations

The Teratological Effects of Anticonvulsants and the Effects on Pregnancy and Birth

1973 • 67 citations

CONGENITAL MALFORMATIONS AND ANTICONVULSANT DRUGS

1973 • 66 citations

Facial clefts in sibs and children of epileptic patients

1986 • 60 citations

ARE ANTICONVULSANTS TERATOGENIC ?

1973 • 59 citations

Antiepileptic drug therapy in pediatrics

1983 • 58 citations

Human Serum Teratogenicity Studied by Rat Embryo Culture: Epilepsy, Anticonvulsant Drugs, and Nutrition

1984 • 58 citations

Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy

1976 • 54 citations

Teratogenicity of Anticonvulsive Medications

1977 • 53 citations

Epilepsy Among Parents of Children with Facial Clefts

1979 • 49 citations

Valproic Acid-Induced Carbamazepine-10,11-Epoxide Toxicity in Children and Adolescents

1990 • 47 citations

Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.

1971 • 46 citations

Developmental toxicity of valproic acid

1991 • 42 citations

Congenital malformations due to anticonvulsive drugs.

1975 • 40 citations

POSSIBLE TERATOGENICITY OF TRIMETHADIONE AND PARAMETHADIONE

1970 • 40 citations

Folate antagonism following teratogenic exposure to diphenylhydantoin

1979 • 40 citations

TERATOGENIC EFFECT OF ANTICONVULSANTS

1973 • 40 citations

Antiepileptic drug therapy and reproductive consequences: Functional and morphologic effects

1991 • 39 citations

ANTICONVULSANTS AND CONGENITAL ABNORMALITIES

1974 • 38 citations

ARE ANTICONVULSANTS TERATOGENIC?

1971 • 37 citations

Fetal trimethadione syndrome

1978 • 35 citations

Serum Protein Binding of Valproic Acid in Fetus‐Mother Pairs Throughout Pregnancy: Correlation With Oxytocin Administration and Albumin and Free Fatty Acid Concentrations

1986 • 35 citations

Pharmacology and mechanisms of action of diphenylhydantoin.

1971 • 34 citations

Phenytoin-induced teratology and gingival pathology

1980 • 34 citations

Protection from Phenytoin‐Induced Congenital Malformations by Coadministration of the Antiepileptic Drug Stiripentol in a Mouse Model

1994 • 33 citations

Assessment of the teratogenic potential of trimethadione in the CD-1 mouse

1979 • 31 citations

Epoxidation of xenobiotics in the human fetus and placenta: A possible mechanism of transplacental drug-induced injuries

1975 • 29 citations

Significance of the phenytoin reactive arene oxide intermediate its oxepin tautomer and clinical factors modifying their roles in phenytoin induced teratology

1980 • 27 citations

Neuronal deficits in mice following phenobarbital exposure during various periods in fetal development

1980 • 24 citations

Epoxide Hydrolase in Human Fetal Liver

1983 • 21 citations

Glutathione and gamma-glutamyl cycle enzymes in human fetal liver.

1981 • 21 citations

[Epilepsy and congenital anomalies].

1973 • 20 citations

Glutathione-S-transferase in human fetal liver

1981 • 18 citations

Formation of carbamazepine epoxide in human fetal liver.

1978 • 18 citations

Decrease of Serum Folates in Healthy Male Volunteers Taking Phenytoin

1988 • 16 citations

Teratogenic effects of diazepam in the hamster

1979 • 15 citations

Epilepsie und Schwangerschaft

1969 • 15 citations

OUTCOME OF PREGNANCY IN WOMEN WITH EPILEPSY

2009 • 14 citations

Teratogenic effects of anticonvulsants.

1971 • 13 citations

FOLIC ACID AND REPRODUCTION

1979 • 10 citations

Phenytoin enhances epoxide metabolism in human fetal liver cultures.

1985 • 9 citations

Passage of Diphenylhydantoin Across The Placenta

1970 • 7 citations

Microsomal enzyme induction by drugs.

1969 • 5 citations

[The effect of diazepam on neonatal neurobehavioral response].

1985 • 3 citations