Inflammatory bio‐markers and cardiovascular risk prediction

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1993 • 28,274 citations

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

2001 • 24,089 citations

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

2000 • 5,760 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

2001 • 4,289 citations

Coronary Plaque Disruption

1995 • 3,542 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction

1999 • 2,478 citations

Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men

2000 • 2,394 citations

Elevated C-Reactive Protein Levels in Overweight and Obese Adults

1999 • 2,384 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men

1999 • 1,952 citations

Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

2000 • 1,945 citations

Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses

2000 • 1,703 citations

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women

1998 • 1,668 citations

Effect of Statin Therapy on C-Reactive Protein Levels

2001 • 1,627 citations

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

1998 • 1,569 citations

Current Concepts of the Pathogenesis of the Acute Coronary Syndromes

2001 • 1,568 citations

Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events

2001 • 1,537 citations

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

1999 • 1,488 citations

Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly∗∗Access the “Journal Club” discussion of this paper at http:/www.elsevier.com/locate/ajmselect/

1999 • 1,467 citations

High-Sensitivity C-Reactive Protein

2001 • 1,398 citations

Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels

1998 • 1,398 citations

Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases

1997 • 1,334 citations

Novel Risk Factors for Systemic Atherosclerosis

2001 • 1,297 citations

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

1998 • 1,238 citations

Markers of Myocardial Damage and Inflammation in Relation to Long-Term Mortality in Unstable Coronary Artery Disease

2000 • 1,220 citations

Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study

1996 • 1,106 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease

1998 • 987 citations

The selecting: vascular adhesion molecules

1995 • 954 citations

Elevation of Tumor Necrosis Factor-α and Increased Risk of Recurrent Coronary Events After Myocardial Infarction

2000 • 922 citations

Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease

2001 • 920 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

2001 • 853 citations

Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

2001 • 839 citations

Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly

1997 • 838 citations

Lipoprotein-Associated Phospholipase A₂as an Independent Predictor of Coronary Heart Disease

2000 • 818 citations

Plasma Concentration of C-Reactive Protein and Risk of Ischemic Stroke and Transient Ischemic Attack: The Framingham Study

2001 • 799 citations

C-Reactive Protein Is a Potent Predictor of Mortality Independently of and in Combination With Troponin T in Acute Coronary Syndromes: A TIMI 11A Substudy

1998 • 788 citations

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

2001 • 783 citations

Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels

2001 • 758 citations

Novel Clinical Markers of Vascular Wall Inflammation

2001 • 750 citations

Function of C-reactive protein

2000 • 743 citations

The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review

2001 • 730 citations

Blood Pressure and Inflammation in Apparently Healthy Men

2001 • 714 citations

Elevation of C-reactive protein in “active” coronary artery disease

1990 • 592 citations

Increased Proinflammatory Cytokines in Patients With Chronic Stable Angina and Their Reduction By Aspirin

1999 • 585 citations

Leucocyte-endothelial interactions and regulation of leucocyte migration

1994 • 584 citations

Circulating Cell Adhesion Molecules and Death in Patients With Coronary Artery Disease

2001 • 574 citations

Generation of C-Reactive Protein and Complement Components in Atherosclerotic Plaques

2001 • 567 citations

Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes

2001 • 565 citations

C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary Arteries

1998 • 561 citations

CD40 Signaling and Plaque Instability

2001 • 560 citations

Soluble P-Selectin and the Risk of Future Cardiovascular Events

2001 • 560 citations

Relationship Between Interleukin 6 and Mortality in Patients With Unstable Coronary Artery Disease

2001 • 551 citations

High-Sensitivity C-Reactive Protein: A Novel and Promising Marker of Coronary Heart Disease

2001 • 534 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events

1999 • 490 citations

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

2000 • 472 citations

Soluble CD40L and Cardiovascular Risk in Women

2001 • 461 citations

Detection and localization of tumor necrosis factor in human atheroma

1990 • 453 citations

The combined role of P- and E-selectins in atherosclerosis.

1998 • 444 citations

Rapid Reduction in C-Reactive Protein With Cerivastatin Among 785 Patients With Primary Hypercholesterolemia

2001 • 416 citations

Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis

2000 • 414 citations

Absence of Diurnal Variation of C-Reactive Protein Concentrations in Healthy Human Subjects

2001 • 402 citations

Soluble adhesion molecules and prediction of coronary heart disease: a prospective study and meta-analysis

2001 • 393 citations

Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study

2001 • 374 citations

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

2000 • 353 citations

Evaluating Novel Cardiovascular Risk Factors: Can We Better Predict Heart Attacks?

1999 • 341 citations

Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall

1996 • 336 citations

Human vascular smooth muscle cells. Target for and source of tumor necrosis factor.

1989 • 333 citations

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

1997 • 330 citations

Vulnerable Plaque

1996 • 281 citations

Deficiency of Inflammatory Cell Adhesion Molecules Protects Against Atherosclerosis in Mice

1997 • 279 citations

Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men

2002 • 274 citations

Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions

1994 • 265 citations

Incremental Prognostic Value of Elevated Baseline C-Reactive Protein Among Established Markers of Risk in Percutaneous Coronary Intervention

2001 • 264 citations

Association of C-reactive protein with markers of prevalent atherosclerotic disease

2001 • 244 citations

A prospective evaluation of lipoprotein-associated phospholipase A2levels and the risk of future cardiovascular events in women

2001 • 217 citations

Triggering of the Human Interleukin-6 Gene by Interferon-γ and Tumor Necrosis Factor-α in Monocytic Cells Involves Cooperation between Interferon Regulatory Factor-1, NFκB, and Sp1 Transcription Factors

1995 • 213 citations

Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis

2002 • 210 citations

C-Reactive Protein, Fibrin D-Dimer, and Incident Ischemic Heart Disease in the Speedwell Study

2001 • 199 citations

Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay

2001 • 181 citations

Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk

2000 • 164 citations

Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene

2002 • 148 citations

Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1.

1994 • 107 citations

The effect of aspirin on C-reactive protein as a marker of risk in unstable angina

2001 • 105 citations

Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease

2002 • 102 citations

Are statins anti-inflammatory?

2000 • 100 citations

C-reactive protein predicts death in patients with previous premature myocardial infarction—A 10 year follow-up study

2002 • 94 citations

Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction

2002 • 56 citations