Common membrane proteins of chromaffin granules, endocrine and synaptic vesicles: Properties, tissue distribution, membrane topography and regulation of synthesis

Peptidergic neurones

1980 • 1,523 citations

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles

1985 • 1,425 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

1985 • 716 citations

Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.

1986 • 671 citations

VAMP-1: a synaptic vesicle-associated integral membrane protein.

1988 • 574 citations

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue.

1981 • 560 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.

1986 • 479 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

The composition of adrenal chromaffin granules: An assessment of controversial results

1976 • 435 citations

Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid.

1983 • 363 citations

The molecular function of adrenal chromaffin granules: Established facts and unresolved topics

1986 • 358 citations

Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane

1988 • 356 citations

The Interaction of Drugs and Subcellular Components in Animal Cells

1969 • 331 citations

Two Vesicle-associated Membrane Protein Genes Are Differentially Expressed in the Rat Central Nervous System

1989 • 326 citations

A Synaptic Vesicle Protein with a Novel Cytoplasmic Domain and Four Transmembrane Regions

1987 • 326 citations

Carboxypeptidase E

1988 • 308 citations

cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+-ATPases.

1988 • 288 citations

Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.

1982 • 283 citations

Dopamine-beta-hydroxylase.

1980 • 283 citations

A synaptic vesicle membrane protein is conserved from mammals to Drosophila

1989 • 272 citations

Immunoreactive substance P and serotonin present in the same dense-core vesicles

1981 • 265 citations

Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens

1985 • 261 citations

IMMUNOFLUORESCENCE OF DOPAMINE-β-HYDROXYLASE APPLICATION OF IMPROVED METHODOLOGY TO THE LOCALIZATION OF THE PERIPHERAL AND CENTRAL NORADRENERGIC NERVOUS SYSTEM

1973 • 245 citations

The Release of Catecholamines from Adrenergic Neurons

1979 • 218 citations

The Isolation of n Granular Fraction from the Suprarenal Medulla, Containing the Symyathomimetic Catechol Amines¹

1953 • 208 citations

Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA.

1987 • 205 citations

The biogenesis of adrenal chromaffin granules

1977 • 203 citations

Cloning and sequence analysis of cDNA for bovine carboxypeptidase E

1986 • 196 citations

Chromogranin immunoreactivity in the central nervous system. Immunochemical characterisation, distribution and relationship to catecholamine and enkephalin pathways

1984 • 193 citations

Endocrine secretory granules and neuronal synaptic vesicles have three integral membrane proteins in common.

1988 • 184 citations

Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein

1989 • 181 citations

Chromogranins A, B, and C: Widespread Constituents of Secretory Vesiclesa

1987 • 177 citations

Exocytotic exposure and recycling of membrane antigens of chromaffin granules: ultrastructural evaluation after immunolabeling.

1986 • 173 citations

Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla.

1982 • 171 citations

Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary.

1986 • 169 citations

The purified ATPase from chromaffin granule membranes is an anion-dependent proton pump.

1987 • 165 citations

Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles

1989 • 164 citations

Structure of the Precursor to an Enzyme Mediating COOH-Terminal Amidation in Peptide Biosynthesis

1987 • 163 citations

The vacuolar ATPase of Neurospora crassa contains an F1-like structure

1989 • 159 citations

Synaptophysin is targeted to similar microvesicles in CHO and PC12 cells.

1989 • 157 citations

Transmembrane Topography and Evolutionary Conservation of Synaptophysin

1989 • 153 citations

Electron transfer across the chromaffin granule membrane.

1983 • 148 citations

A carboxypeptidase processing enzyme for enkephalin precursors

1982 • 148 citations

cDNA sequence and homologies of the “57-kDa” nucleotide-binding subunit of the vacuolar ATPase from Arabidopsis.

1988 • 148 citations

Localization of adrenaline in cytoplasmic particles of the bovine adrenal medulla

1953 • 147 citations

Neural and humoral factors separately regulate neuropeptide Y, enkephalin, and chromogranin A and B mRNA levels in rat adrenal medulla.

1988 • 140 citations

DETERMINATION OF BRAIN‐SPECIFIC ANTIGENS IN SHORT TERM CULTIVATED RAT ASTROGLIAL CELLS AND IN RAT SYNAPTOSOMES

1975 • 140 citations

Dopamine-β-Hydroxylase: A Tetrameric Glycoprotein

1973 • 139 citations

Dynamic aspects of chromaffin granule structure

1982 • 138 citations

The cell biology of the nerve terminal

1988 • 136 citations

Characterization of a H+-ATPase in rat brain synaptic vesicles

1989 • 132 citations

MECHANISMS INVOLVED IN THE RELEASE OF NORADRENALINE FROM SYMPATHETIC NERVES

1973 • 131 citations

Subcellular fractionation of splenic nerve: ATP, chromogranin A and dopamine β-hydroxylase in noradrenergic vesicles

1970 • 131 citations

Rat adrenal medulla: Levels of chromogranins, enkephalins, dopamine β-hydroxylase and of the amine transporter are changed by nervous activity and hypophysectomy

1987 • 131 citations

Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein.

1987 • 128 citations

Reserpine binding to bovine chromaffin granule membranes. Characterization and comparison with dihydrotetrabenazine binding.

1984 • 127 citations

Multiple pathways of exocytosis, endocytosis, and membrane recycling: validation of a Golgi route.

1983 • 126 citations

The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.

1987 • 125 citations

APPLICATIONS OF IMMUNOHISTOCHEMISTRY TO STUDIES ON MONOAMINE CELL SYSTEMS WITH SPECIAL REFERENCE TO NERVOUS TISSUES*

1975 • 119 citations

Opioid peptides and noradrenaline co-exist in large dense-cored vesicles from sympathetic nerve

1982 • 117 citations

Glycoproteins and proteoglycans of the chromaffin granule matrix.

1982 • 116 citations

Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

1989 • 116 citations

Mitochondrial enzymes and chromaffin granules

1957 • 115 citations

A novel ATPase in the chromaffin granule membrane.

1983 • 114 citations

Membrane proteins of chromaffin granules. Dopamine β-hydroxylase, a major constituent

1972 • 113 citations

Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla.

1986 • 112 citations

An Adenosine Triphosphatase Isolated from Chromaffin-Granule Membranes is Closely Similar to F1-Adenosine Triphosphatase of Mitochondria

1979 • 106 citations

Bovine splenic nerve: characterization of noradrenaline‐containing vesicles and other cell organelles by density gradient centrifugation

1969 • 103 citations

The structure of cytochrome b561, a secretory vesicle-specific electron transport protein.

1988 • 102 citations

Isolation of ATPase I, the proton pump of chromaffin-granule membranes

1985 • 99 citations

P29: a novel tyrosine-phosphorylated membrane protein present in small clear vesicles of neurons and endocrine cells.

1990 • 99 citations

Cloning of cDNA encoding a 32-kDa protein. An accessory polypeptide of the H+-ATPase from chromaffin granules.

1988 • 96 citations

The primary structure of glycoprotein III from bovine adrenal medullary chromaffin granules. Sequence similarity with human serum protein-40,40 and rat Sertoli cell glycoprotein.

1990 • 96 citations

Purification of N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes.

1986 • 94 citations

Purification and Characterization of a Membrane‐Bound Enkephalin‐Forming Carboxypeptidase, “Enkephalin Convertase”

1984 • 93 citations

Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes.

1988 • 88 citations

Lysosomal H+-translocating ATPase has a similar subunit structure to chromaffin granule H+-ATPase complex

1989 • 87 citations

Organisation of the proteins of the chromaffin granule membrane

1980 • 86 citations

The localization of lysosomal enzymes in chromaffin tissue

1966 • 84 citations

Cytochrome b561 catalyzes transmembrane electron transfer.

1984 • 83 citations

Isolation and Immunological Characterization of a Glycoprotein from Adrenal Chromaffin Granules

1984 • 83 citations

Rat brain synaptic vesicles and synaptic plasma membranes compared by crossed immunoelectrophoresis

1975 • 78 citations

Inhibition of adenosine triphosphatase, 5-hydroxytryptamine transport and proton-translocation activities of resealed chromaffin-granule ‘ghosts’

1980 • 77 citations

Biochemical and functional properties of large and small dense-core vesicles in sympathetic nerves of rat and ox vas deferens

1984 • 76 citations

Characterization of a peptide alpha-amidation activity from rat anterior pituitary.

1984 • 76 citations

Dopamine β‐Hydroxylase and Other Glycoproteins from the Soluble Content and the Membranes of Adrenal Chromaffin Granules: Isolation and Carbohydrate Analysis

1982 • 74 citations

Fractionation of synaptophysin‐containing vesicles from rat brain and cultured PC12 pheochromocytoma cells

1988 • 73 citations

Composition and biogenesis of complex carbohydrates of ox adrenal chromaffin granules

1977 • 72 citations

Cloning and sequence of cDNA encoding a peptide C-terminal α-amidating enzyme from Xenopuslaevis

1987 • 71 citations

An identical cytochrome b561 is present in bovine adrenal chromaffin vesicles and posterior pituitary neurosecretory vesicles.

1984 • 71 citations

Uptake of adenosine triphosphate by isolated adrenal chromaffin granules: A carrier-mediated transport

1977 • 70 citations

Rat Preprocarboxypeptidase H

1989 • 67 citations

Exocytotic exposure and retrieval of membrane antigens of chromaffin granules: quantitative evaluation of immunofluorescence on the surface of chromaffin cells.

1984 • 67 citations

Distribution and properties of adrenergic storage vesicles in nerve terminals.

1976 • 66 citations

VAT 1: An abundant membrane protein from torpedo cholinergic synaptic vesicles

1989 • 65 citations

In Adrenal Medulla Synaptophysin (Protein p38) Is Present in Chromaffin Granules and in a Special Vesicle Population

1988 • 65 citations

Membrane-associated peptidylglycine alpha-amidating monooxygenase in the heart.

1988 • 63 citations

The p65 protein is a calmodulin-binding protein present in several types of secretory vesicles

1989 • 59 citations

Structure of bovine adrenal dopamine .beta.-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide

1989 • 58 citations

Calcitonin gene-related peptide and chromogranin a: Presence and intra-axonal transport in lumbar motor neurons in the rat, a comparison with synaptic vesicle antigens in immunohistochemical studies

1989 • 57 citations

Purified cytochrome b561 catalyzes transmembrane electron transfer for dopamine beta-hydroxylase and peptidyl glycine alpha-amidating monooxygenase activities in reconstituted systems.

1987 • 57 citations

Most Synaptic Vesicles Isolated from Rat Brain Carry Three Membrane Proteins, SV2, Synaptophysin, and p65

1989 • 56 citations

A Similar Calmodulin‐Binding Protein Expressed in Chromaffin, Synaptic, and Neurohypophyseal Secretory Vesicles

1988 • 54 citations

Evidence for the presence of dopamine‐β‐hydroxylase in both populations of noradrenaline storage vesicles in sympathetic nerve terminals of the rat vas deferens

1973 • 54 citations

Evidence for the coexistence and co-release of [met]enkephalin and noradrenaline from sympathetic nerves of the bovine vas deferens

1987 • 53 citations

Stimulus-secretion coupling in chromaffin cells

1987 • 53 citations

Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzyme.

1985 • 52 citations

Unusual redox behaviour of cytochrome b-561 from bovine chromaffin granule membranes

1984 • 52 citations

Quantification of p38/synaptophysin in highly purified adrenal medullary chromaffin vesicles

1988 • 50 citations

CHARACTERIZATION AND TOPOGRAPHY OF THE GLYCOPROTEINS OF ADRENAL CHROMAFFIN GRANULES

1979 • 50 citations

Purification of cytochrome b-561

1974 • 49 citations

Noradrenaline formation from dopamine in isolated subcellular particles from bovine splenic nerve

1967 • 49 citations

An immunological characterization of five common antigens of chromaffin granules and of large dense-cored vesicles of sympathetic nerve

1986 • 48 citations

The membrane-binding segment of dopamine β-hydroxylase is not an uncleaved signal sequence

1989 • 48 citations

Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons.

1984 • 47 citations

Mechanism of Ascorbic Acid Regeneration Mediated by Cytochrome b₅₆₁a

1987 • 45 citations

Insulin hypoglycemia increases the levels of neuropeptide Y and calcitonin gene-related peptide, but not of chromogranins A and B, in rat chromaffin granules

1989 • 44 citations

Evidence for the co‐storage and co‐release of neuropeptide y and noradrenaline from large dense cored vesicles in sympathetic nerves of the bovine vas deferens

1988 • 43 citations

IMMUNOLOGICAL STUDIES ON A MEMBRANE PROTEIN (CHROMOMEMBRIN B) OF CATECHOLAMINE‐STORING VESICLES

1973 • 42 citations

Membranes of chromaffin granules. Isolation and partial characterization of two proteins

1971 • 41 citations

Identification of two glycoproteins of chromaffin granules as the carboxypeptidase H

1986 • 39 citations

Photoinactivation and identification of the biogenic amine transporter in chromaffin granules from bovine adrenal medulla.

1982 • 38 citations

Glycoproteins of the Chromaffin Granule Membrane: Separation by Two‐Dimensional Electrophoresis and Identification by Lectin Binding

1984 • 37 citations

Subcellular Distribution of 65,000 Calmodulin‐Binding Protein (p65) and Synaptophysin (p38) in Adrenal Medulla

1989 • 37 citations

Sympathetic axons and nerve terminals: The protein composition of small and large dense-core and of a third type of vesicles

1990 • 37 citations

The arrangement of dopamine β‐hydroxylase (EC 1.14.2.1) and chromomembrin B in the membrane of chromaffin granules

1976 • 36 citations

The asymmetric orientation of cytochrome b561 in bovine chromaffin granule membranes

1984 • 36 citations

Specificity and properties of the nucleotide carrier in chromaffin granules from bovine adrenal medulla

1983 • 36 citations

Adrenal chromaffin granules: evidence for an ultrastructural equivalent of the proton-pumping ATPase.

1982 • 35 citations

Localization of synaptin on synaptic vesicle membranes, synaptosomal plasma membranes and chromaffin granule membranes

1977 • 34 citations

Demonstration of immunochemical identity between the synaptic vesicle proteins synaptin and synaptophysin/p38

1988 • 32 citations

Cytochrome b561 can be detected in many neuroendocrine tissues using a specific monoclonal antibody

1987 • 31 citations

Photoaffinity labeling of the monoamine transporter of bovine chromaffin granules and other monamine storage vesicles using 7-azide-8-[125I]iodoketanserin

1989 • 31 citations

Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens

1989 • 30 citations

Neuronally mediated enzyme induction in adrenergic neurons and adrenal chromaffin cells.

1972 • 29 citations

Heterogeneous distribution of synaptophysin and protein 65 in synaptic vesicles isolated from rat cerebral cortex

1988 • 28 citations

Cellular and Molecular Basis of Synaptic Transmission.

1989 • 27 citations

Enkephalin Convertase in the Gastrointestinal Tract and Associated Organs Characterized and Localized with [³H]Guanidinoethylmercaptosuccinic Acid*

1987 • 27 citations

Characterization, by Size, Density, Osmotic Fragility, and Immunoaffinity, of Acetylcholine‐ and Vasoactive Intestinal Polypeptide‐Containing Storage Particles from Myenteric Neurones of the Guinea‐Pig

1989 • 27 citations

Synaptic Vesicles from Mammalian Brain: Large‐Scale Purification and Physical and Immunochemical Characterization

1988 • 27 citations

Enkephalin Convertase Demonstrated in the Pituitary and Adrenal Gland by³HGuanidinoethylmercaptosuccinic Acid Autoradiography: Dehydration Decreases Neurohypophyseal Levels*

1985 • 27 citations

Pathways of endocytosis in secretory cells

1981 • 27 citations

Properties of a novel ATPase enzyme in chromaffin granules

1982 • 27 citations

BIOCHEMICAL STUDIES OF THE MECHANISM OF RELEASE

1979 • 27 citations

Immunological characterization of a membrane glycoprotein of chromaffin granules: Its presence in endocrine and exocrine tissues

1988 • 24 citations

Cytochrome b-561 in sympathetic nerve terminal vesicles from rat vas deferens

1978 • 24 citations

Enkephalin convertase: localization to specific neuronal pathways

1986 • 24 citations

Cholinergic nerve terminals in the rat diaphragm are chromogranin A immunoreactive

1987 • 22 citations

Bovine membranous dopamine beta-hydroxylase is not anchored via covalently attached phosphatidylinositol.

1988 • 21 citations

Enkephalin Convertase in the Heart: Similar Disposition to Atrial Natriuretic Factor*

1988 • 21 citations

Dopamine β‐hydroxylase distribution in density gradients: Physiological and artefactual implications

1979 • 20 citations

Identification and Characterization of the Major Proteins of Mammalian Brain Synaptic Vesicles

1988 • 19 citations

Increased specific activity of membrane‐bound dopamine β‐hydroxylase in chromaffin granules after reserpine treatment

1977 • 18 citations

The recycling of a secretory granule membrane protein

1989 • 18 citations

Distribution of [³H]Dihydrotetrabenazine Binding in Bovine Striatal Subsynaptic Fractions: Enrichment of Higher Affinity Binding in a Synaptic Vesicle Fraction

1988 • 16 citations

Evolution of vacuolar H⁺-ATPases: immunological relationships of the nucleotide-binding subunits

1989 • 16 citations

Purification and Characterization of a Peptide C-Terminal α-Amidating Enzyme from Porcine Atrium1

1989 • 15 citations

Immunohistochemical demonstration of a membrane protein of chromaffin granules in adrenal medulla and symphathetic nerve

1971 • 15 citations

Purification and Subunit Composition of a Cholinergic Synaptic Vesicle Glycoprotein, Phosphointermediate‐Forming ATPase

1989 • 14 citations

An Improved Method for the Purification of “Light” Noradrenaline Vesicles from Rat Vas Deferens: Some Biochemical Characteristics

1983 • 14 citations

Adenine nucleotide and phosphoenolpyruvate transport by bovine chromaffin granule “ghosts”

1983 • 14 citations

Conversion of soluble dopamine β-hydroxylase to a membrane binding form

1989 • 14 citations

Subcellular distribution and axonal transport of noradrenaline, dopamine-β-hydroxylase and neuropeptide Y in dog splenic nerve☆

1989 • 12 citations

Adrenergic and Cholinergic Vesicles: Are there Common Antigens and Common Properties?

1988 • 8 citations

Noradrenergic Vesicles

1984 • 8 citations

A peptidyl α‐amidation activity in chromaffin granules of bovine adrenal medulla

1989 • 7 citations

APPLICATION OF IMPROVED METHODOLOGY TO THE LOCALIZATION OF THE PERIPHERAL AND CENTRAL NORADRENERGIC NERVOUS SYSTEM"2

1973 • 5 citations