The Evolutionary Origins of Hormones, Neurotransmitters, and Other Extracellular Chemical Messengers

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

1969 • 1,680 citations

Peptidergic neurones

1980 • 1,523 citations

Hepatogastroenterology

2011 • 1,348 citations

‘Pheromones’: a New Term for a Class of Biologically Active Substances

1959 • 1,320 citations

Identification of insulin in rat brain.

1978 • 599 citations

FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS

1975 • 408 citations

The influence of the posterior and inter-mediate lobe of the pituitary and pituitary peptides on the maintenance of a conditioned avoidance response in rats

1965 • 376 citations

PHYLOGENY AND ONTOGENY OF HORMONE RECEPTORS: THE SELECTION THEORY OF RECEPTOR FORMATION AND HORMONAL IMPRINTING

1980 • 311 citations

Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes.

1980 • 281 citations

Ionic Mechanisms of Excitation in Paramecium

1979 • 268 citations

Insulin and insulin receptors in rodent brain

1981 • 197 citations

Insulin acting as a modulator of feeding through the hypothalamus

1981 • 188 citations

Myxobacteria: Cell Interactions, Genetics, and Development

1979 • 184 citations

Glucagon-like and insulin-like hormones of the insect neurosecretory system

1976 • 140 citations

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

1980 • 140 citations

Brain Peptides

1981 • 138 citations

Presence in Normal Human Testes of a Chorionic-Gonadotropin-like Substance Distinct from Human Luteinizing Hormone

1975 • 132 citations

Insulin or a closely related molecule is native to Escherichia coli.

1981 • 132 citations

The Biosynthesis of Catecholamines in Two Genera of Protozoa

1966 • 122 citations

Isolation of material displaying insulin-like immunological biological activity from the brain of the blowfly Calliphora vomitoria

1979 • 121 citations

Somatostatin — both hormone and neurotransmitter?

1978 • 121 citations

TUMOUR AND PLASMA ACTH CONCENTRATIONS IN PATIENTS WITH AND WITHOUT THE ECTOPIC ACTH SYNDROME

1972 • 118 citations

Aggregation and Differentiation in the Cellular Slime Molds

1971 • 114 citations

Insulin-producing cells in the gut of freshwater bivalve molluscs Anodonta cygnea and Unio pictorum and the role of insulin in the regulation of their carbohydrate metabolism

1978 • 96 citations

Gastrin/cholecystokinin (CCK)-like immunoreactive neurones in the brain of the blowfly, Calliphora erythrocephala (Diptera)

1981 • 91 citations

Insulin in Invertebrates and Cyclostomes

1973 • 83 citations

Cytochemical and immunofluorescence investigations on insulin-like producing cells in the intestine of Mytilus edulis L. (Bivalvia)

1976 • 69 citations

Production of choriogonadotropin-like factor by a microorganism.

1979 • 69 citations

Serotonin in protozoa

1966 • 69 citations

Naloxone-reversible effect of opioids on pinocytosis in Amoeba proteus

1979 • 66 citations

Evidence against extrapancreatic insulin synthesis.

1981 • 65 citations

Immunohistochemical localization of a choriogonadotropin-like protein in bacteria isolated from cancer patients

1978 • 58 citations

Epinephrine and serotonin activation of adenyl cyclase from Tetrahymena pyriformis

1972 • 58 citations

Hormones from tumors: Are they ubiquitous?

1980 • 45 citations

Insulin in insects and annelids

1981 • 40 citations

Influence of the age of erythrocytes on their insulin receptors

1980 • 32 citations

Peptides in metabolic autonomic nerves

1981 • 24 citations

The Role of the Steroid Sex Pheromone Antheridiol in Controlling the Development of Male Sex Organs in the Water Mold, Achlya

1981 • 21 citations

Synthesis of Immunoreactive Insulin in Vitro by Aplastic Mammary Carcinoma Preconditioned in Diabetic Mice

1981 • 15 citations

A gastrin/CCK-like peptide in coelenterates

1980 • 3 citations