Cardiotoxicity of anticancer treatments: what the cardiologist needs to know

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Heart Disease: A Textbook of Cardiovascular Medicine.

1984 • 4,239 citations

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

2009 • 3,773 citations

Risk Factors for Doxorubicin-lnduced Congestive Heart Failure

1979 • 2,308 citations

Congestive heart failure in patients treated with doxorubicin

2003 • 2,070 citations

A clinicopathologic analysis of adriamycin cardiotoxicity

1973 • 1,534 citations

A Comparison of Letrozole and Tamoxifen in Postmenopausal Women with Early Breast Cancer

2005 • 1,530 citations

Bone Marrow Transplant

2016 • 1,367 citations

2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults

2009 • 1,327 citations

Guidelines on the Diagnosis and Management of Pericardial Diseases Executive SummaryThe Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology

2004 • 1,317 citations

USE OF CHEMOTHERAPY PLUS A MONOCLONAL ANTIBODY AGAINST HER2 FOR METASTATIC BREAST CANCER THAT OVEREXPRESSES HER2

2009 • 1,262 citations

Cardiovascular Complications of Cancer Therapy

2009 • 1,172 citations

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

2006 • 1,126 citations

Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort

2009 • 1,056 citations

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

2007 • 1,033 citations

Phase II Placebo-Controlled Randomized Discontinuation Trial of Sorafenib in Patients With Metastatic Renal Cell Carcinoma

2006 • 1,030 citations

Anthracycline-Induced Cardiomyopathy

2010 • 1,028 citations

Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries

2005 • 993 citations

Prevention of High-Dose Chemotherapy–Induced Cardiotoxicity in High-Risk Patients by Angiotensin-Converting Enzyme Inhibition

2006 • 979 citations

Cardiac Toxicity 4 to 20 Years After Completing Anthracycline Therapy

1991 • 934 citations

Arterial Thromboembolic Events in Patients with Metastatic Carcinoma Treated with Chemotherapy and Bevacizumab

2007 • 912 citations

ErbB2 is essential in the prevention of dilated cardiomyopathy

2002 • 875 citations

Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy

2004 • 865 citations

Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma

2007 • 824 citations

Mechanisms and Models in Heart Failure

2005 • 815 citations

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

2009 • 799 citations

Assessment of Cardiac Dysfunction in a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel, With or Without Trastuzumab As Adjuvant Therapy in Node-Positive, Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer: NSABP B-31

2005 • 795 citations

Mechanisms and Models in Heart Failure

1999 • 777 citations

Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion

1982 • 768 citations

Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

2007 • 765 citations

American Society of Clinical Oncology Clinical Evidence Review on the Ongoing Care of Adult Cancer Survivors: Cardiac and Pulmonary Late Effects

2007 • 760 citations

Factors Affecting Late Mortality From Heart Disease After Treatment of Hodgkin's Disease

1993 • 742 citations

Reversibility of Trastuzumab-Related Cardiotoxicity: New Insights Based on Clinical Course and Response to Medical Treatment

2005 • 707 citations

Protective Effects of Carvedilol Against Anthracycline-Induced Cardiomyopathy

2006 • 686 citations

Islam and Liberal Democracy: A Historical Overview

1996 • 658 citations

Randomized Phase III Study of Pegylated Liposomal Doxorubicin Plus Bortezomib Compared With Bortezomib Alone in Relapsed or Refractory Multiple Myeloma: Combination Therapy Improves Time to Progression

2007 • 636 citations

Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

1983 • 634 citations

Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer.

1997 • 628 citations

Type II Chemotherapy-Related Cardiac Dysfunction: Time to Recognize a New Entity

2005 • 616 citations

Anthracycline cardiomyopathy monitored by morphologic changes.

1978 • 589 citations

Phase III Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Docetaxel (AC→T) with Doxorubicin and Cyclophosphamide Followed by Docetaxel and Trastuzumab (AC→TH) with Docetaxel, Carboplatin and Trastuzumab (TCH) in Her2neu Positive Early Breast Cancer Patients: BCIRG 006 Study.

2009 • 572 citations

Trastuzumab-Associated Cardiac Adverse Effects in the Herceptin Adjuvant Trial

2007 • 558 citations

Cardiac Safety Analysis of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With or Without Trastuzumab in the North Central Cancer Treatment Group N9831 Adjuvant Breast Cancer Trial

2008 • 531 citations

Heart Disease: A Textbook of Cardiovascular Medicine

1980 • 501 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Phase II Study of Sunitinib Malate, an Oral Multitargeted Tyrosine Kinase Inhibitor, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

2008 • 486 citations

Cardiovascular Status in Long-Term Survivors of Hodgkin's Disease Treated With Chest Radiotherapy

2004 • 484 citations

Radiation heart disease

1981 • 466 citations

Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial

2009 • 458 citations

Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer

2010 • 427 citations

Trastuzumab-Related Cardiotoxicity: Calling Into Question the Concept of Reversibility

2007 • 386 citations

Cardiac disturbances during the administration of taxol.

1991 • 380 citations

Doxorubicin, Cardiac Risk Factors, and Cardiac Toxicity in Elderly Patients With Diffuse B-Cell Non-Hodgkin's Lymphoma

2008 • 362 citations

Protective Effect of the Bispiperazinedione ICRF-187 against Doxorubicin-Induced Cardiac Toxicity in Women with Advanced Breast Cancer

1988 • 358 citations

Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study

2007 • 323 citations

Cardiac Safety of Lapatinib: Pooled Analysis of 3689 Patients Enrolled in Clinical Trials

2008 • 314 citations

Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy

2002 • 305 citations

Suppression of Doxorubicin Cardiotoxicity by Overexpression of Catalase in the Heart of Transgenic Mice

1996 • 305 citations

Anthracyclines Induce Calpain-dependent Titin Proteolysis and Necrosis in Cardiomyocytes

2004 • 300 citations

Cardiac Safety of Lapatinib: Pooled Analysis of 3689 Patients Enrolled in Clinical Trials

2008 • 285 citations

Delayed administration of dexrazoxane provides cardioprotection for patients with advanced breast cancer treated with doxorubicin-containing therapy.

1997 • 271 citations

Adriamycin cardiomyopathy—risk factors

1977 • 258 citations

Different anthracycline derivates for reducing cardiotoxicity in cancer patients

2010 • 255 citations

Congestive heart failure is a rare event in patients receiving imatinib therapy

2007 • 252 citations

A prospective randomized comparison of epirubicin and doxorubicin in patients with advanced breast cancer.

1985 • 247 citations

Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation.

2007 • 237 citations

N-Terminal Pro-B-Type Natriuretic Peptide after High-Dose Chemotherapy: A Marker Predictive of Cardiac Dysfunction?

2005 • 233 citations

Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoring

2009 • 212 citations

Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia

2000 • 206 citations

Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis

2009 • 194 citations

Cardiotoxicity Profile of Trastuzumab

2008 • 193 citations

Clinical and angiographic features of coronary artery disease after chest irradiation

1987 • 178 citations

Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies

2003 • 173 citations

New Insight Into Epirubicin Cardiac Toxicity: Competing Risks Analysis of 1097 Breast Cancer Patients

2008 • 169 citations

The risk of venous thromboembolic disease associated with adjuvant hormone therapy for breast carcinoma

2004 • 162 citations

Cardiac safety of liposomal anthracyclines

2004 • 160 citations

111Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure: A clue to uncover the mechanisms of trastuzumab-related cardiotoxicity

2007 • 159 citations

Cardiotoxicity after anthracycline chemotherapy in breast carcinoma: Effects on left ventricular ejection fraction, troponin I and brain natriuretic peptide

2009 • 152 citations

High-Density Lipoproteins Protect Isolated Rat Hearts From Ischemia-Reperfusion Injury by Reducing Cardiac Tumor Necrosis Factor-α Content and Enhancing Prostaglandin Release

2003 • 147 citations

Cardiotoxicity in patients receiving transtuzumab (Herceptin): primary toxicity, synergistic or sequential stress, or surveillance artifact?

1999 • 133 citations

Mitoxantrone: an overview of safety and toxicity

1985 • 122 citations

Natriuretic peptides during the development of doxorubicin‐induced left ventricular diastolic dysfunction

2002 • 115 citations

Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model.

1993 • 113 citations

Pegylated Liposomal Doxorubicin Plus Docetaxel Significantly Improves Time to Progression Without Additive Cardiotoxicity Compared With Docetaxel Monotherapy in Patients With Advanced Breast Cancer Previously Treated With Neoadjuvant-Adjuvant Anthracycline Therapy: Results From a Randomized Phase III Study

2009 • 112 citations

Radiation-induced Heart Disease: Review of Experimental Data on Dose Reponse and Pathogenesis

1992 • 112 citations

Understanding and managing the possible adverse effects associated with bevacizumab

2009 • 109 citations

Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: a randomised, multicentre open-label phase II study

2010 • 109 citations

Alcohol and Cardiovascular Diseases

2002 • 108 citations

Long-Term Cardiac Follow-Up in Relapse-Free Patients After Six Courses of Fluorouracil, Epirubicin, and Cyclophosphamide, With Either 50 or 100 mg of Epirubicin, As Adjuvant Therapy for Node-Positive Breast Cancer: French Adjuvant Study Group

2004 • 97 citations

A woman's heart

2009 • 92 citations

Hypertension secondary to anti-angiogenic therapy: experience with bevacizumab.

2007 • 88 citations

Phase II Trial of Liposome-Encapsulated Doxorubicin, Cyclophosphamide, and Fluorouracil as First-Line Therapy in Patients With Metastatic Breast Cancer

1999 • 86 citations

Biophysical chemistry of the daunomycin-DNA interaction

1990 • 85 citations

Assessment of Anthracycline Cardiomyopathy by Endomyocardial Biopsy

1994 • 83 citations

Trastuzumab-Induced Cardiomyopathy: Not as Benign as it Looks? A Retrospective Study

2009 • 70 citations

Fulminant fatal cardiotoxicity following cyclophosphamide therapy

2009 • 65 citations

Neurotoxic and cardiotoxic effects of cocaine and ethanol

2009 • 63 citations

Phase II Study of Cisplatin Plus Epirubicin Salvage Chemotherapy in Refractory Germ Cell Tumors

2006 • 55 citations

Evaluation of mitoxantrone cardiac toxicity by nuclear angiography and endomyocardial biopsy: an update

1985 • 55 citations

Adult multicenter trials using dexrazoxane to protect against cardiac toxicity.

1998 • 49 citations

Doxorubicin cardiotoxicity in children: Comparison of a consecutive divided daily dose administration schedule with single dose (rapid) infusion administration

1998 • 48 citations

Trastuzumab cardiotoxicity: biological hypotheses and clinical open issues

2008 • 33 citations

Alcohol and Cardiovascular Diseases: A Historical Overview

2007 • 30 citations

BNP cannot replace gated equilibrium radionuclide ventriculography in monitoring of anthracycline-induced cardiotoxity

2007 • 29 citations

Cyclophosphamide cardiac injury mimicking acute myocardial infarction.

1993 • 29 citations

P176 Cardiac safety guidelines for the adjuvant use of trastuzumab (Herceptin®) in HER2-positive early breast cancer

2007 • 26 citations

Serious arterial thromboembolic events (sATE) in patients (pts) with metastatic colorectal cancer (mCRC) treated with bevacizumab (BV): Results from the BRiTE registry

2007 • 22 citations

Myocardial Infarction after Irradiation in Hodgkin’s Disease: A Review

1993 • 21 citations

Appraising cardiotoxicity associated with liposomal doxorubicin by means of tissue Doppler echocardiography end-points

2008 • 21 citations

Cancer and the Heart

2006 • 16 citations

Genetic variants in human carbonyl reductase 3 (CBR3) and their influence on doxorubicin pharmacokinetics in Asian breast cancer patients

2007 • 2 citations

Deleted Work

1955 • 0 citations