CD40—CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.

1991 • 203 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

Soluble forms of CD40 inhibit biologic responses of human B cells.

1992 • 154 citations

Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen.

1992 • 143 citations

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

1987 • 141 citations

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.

1994 • 134 citations

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B- lineage non-Hodgkin's lymphoma cells

1990 • 129 citations

γ/δ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes.

1995 • 112 citations

Regulation of IgE synthesis in humans: A tale of two signals

1991 • 103 citations

Interleukin 7 receptor ligation stimulates tyrosine phosphorylation, inositol phospholipid turnover, and clonal proliferation of human B-cell precursors.

1991 • 90 citations

Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors.

1990 • 89 citations

Decreased expression of the ligand for CD40 in newborn lymphocytes

1994 • 74 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations

CD40 ligation induces lymphotoxin α gene expression in human B cells

1994 • 66 citations

Structure of the murine CD40 ligand gene

1994 • 29 citations

Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE

1994 • 20 citations

Chromosomal localization of the gene for human B-cell antigen CD40

1993 • 18 citations

Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells

1995 • 18 citations